Browsing by Author "Rojas, P."

Now showing 1 - 15 of 15
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    A stress test for climate change impacts on water security : A CRIDA case study
    (2020) Verbist, K. M. J.; Maureira-Cortes, H.; Rojas, P.; Vicuña Díaz, Sebastián
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    Admission of Hematopoietic Cell Transplantation Patients to the Intensive Care Unit at the Pontificia Universidad Catolica de Chile Hospital
    (2015) Escobar, K.; Rojas, P.; Ernst Diaz, Daniel Matias; Bertín Cortes Monroy, Pablo; Nervi Nattero, Bruno; Jara, V.; Garcia, M.; Ocqueteau Tachini, Mauricio; Sarmiento Maldonado, Mauricio; Ramirez, P.
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    Analysis of apheresis outcomes in a cohort of Chilean patients treated with autologous stem cell transplantation: A single center real-world experience
    (2024) Sarmiento, M.; Salinas, J.; Rojas, P.; Gutierrez, C.; Vidal, M.; Jara, V; Garcia, M. J.; Campbell, M. J.; Flores, Y.; Sandoval, V; Vergara, M.; Palacios, F.; Ocqueteau, M.
    Adequate stem cell harvesting is required for autologous hematopoietic transplantation. In deficient mobilizer patients, the collection of stem cells can be challenging because of the impossibility of achieving satisfactory CD34 cell counts with GCSF + - chemotherapy. Plerixafor is a potent and expensive drug that promotes the release of stem cells from the medullary niche to the peripheral blood and allows satisfactory harvests. We performed a retrospective analysis of 370 patients with myeloma and lymphoma harvested at our institution. 99 % of patients achieved satisfactory apheresis using Plerixafor in 45 %. Satisfactory harvests were obtained in patients mobilized with GCSF or plerixafor. In patients who used plerixafor, it was necessary to perform fewer apheresis procedures (P = 0.05). In multivariate analysis, the only factor that predicted the need for plerixafor was the presence of less than 30,000 CD34 / ul on the day of apheresis (OR 0.3. p < 0.001). Since we adopted the plerixafor protocol guided by CD34 counts, the number of patients with harvest failure has decreased. In conclusion, the rational and standardized use of plerixafor favors satisfactory harvest in patients who require autologous transplantation in South-American patients.
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    Animal fibers as water reservoirs for internal curing of mortars and their limits caused by fiber clustering
    (2021) Antico, F. C.; Rojas, P.; Briones, F.; Araya Letelier, Gerardo Andrés
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    Baseline brain function in the preadolescents of the ABCD Study
    (2021) Chaarani, B.; Hahn, S.; Allgaier, N.; Adise, S.; Owens, M. M.; Juliano, A. C.; Yuan, D. K.; Loso, H.; Ivanciu, A.; Albaugh, M. D.; Dumas, J.; Mackey, S.; Laurent, J.; Ivanova, M.; Hagler, D. J.; Cornejo, M. D.; Hatton, S.; Agrawal, A.; Aguinaldo, L.; Ahonen, L.; Aklin, W.; Anokhin, A. P.; Arroyo, J.; Avenevoli, S.; Babcock, D.; Bagot, K.; Baker, F. C.; Banich, M. T.; Barch, D. M.; Bartsch, H.; Baskin-Sommers, A.; Bjork, J. M.; Blachman-Demner, D.; Bloch, M.; Bogdan, R.; Bookheimer, S. Y.; Breslin, F.; Brown, S.; Calabro, F. J.; Calhoun, V; Casey, B. J.; Chang, L.; Clark, D. B.; Cloak, C.; Constable, R. T.; Constable, K.; Corley, R.; Cottler, L. B.; Coxe, S.; Dagher, R. K.; Dale, A. M.; Dapretto, M.; Delcarmen-Wiggins, R.; Dick, A. S.; Do, E. K.; Dosenbach, N. U. F.; Dowling, G. J.; Edwards, S.; Ernst, T. M.; Fair, D. A.; Fan, C. C.; Feczko, E.; Feldstein-Ewing, S. W.; Florsheim, P.; Foxe, J. J.; Freedman, E. G.; Friedman, N. P.; Friedman-Hill, S.; Fuemmeler, B. F.; Galvan, A.; Gee, D. G.; Giedd, J.; Glantz, M.; Glaser, P.; Godino, J.; Gonzalez, M.; Gonzalez, R.; Grant, S.; Gray, K. M.; Haist, F.; Harms, M. P.; Hawes, S.; Heath, A. C.; Heeringa, S.; Heitzeg, M. M.; Hermosillo, R.; Herting, M. M.; Hettema, J. M.; Hewitt, J. K.; Heyser, C.; Hoffman, E.; Howlett, K.; Huber, R. S.; Huestis, M. A.; Hyde, L. W.; Iacono, W. G.; Infante, M. A.; Irfanoglu, O.; Isaiah, A.; Iyengar, S.; Jacobus, J.; James, R.; Jean-Francois, B.; Jernigan, T.; Karcher, N. R.; Kaufman, A.; Kelley, B.; Kit, B.; Ksinan, A.; Kuperman, J.; Laird, A. R.; Larson, C.; LeBlanc, K.; Lessov-Schlagger, C.; Lever, N.; Lewis, D. A.; Lisdahl, K.; Little, A. R.; Lopez, M.; Luciana, M.; Luna, B.; Madden, P. A.; Maes, H. H.; Makowski, C.; Marshall, A. T.; Mason, M. J.; Matochik, J.; McCandliss, B. D.; McGlade, E.; Montoya, I; Morgan, G.; Morris, A.; Mulford, C.; Murray, P.; Nagel, B. J.; Neale, M. C.; Neigh, G.; Nencka, A.; Noronha, A.; Nixon, S. J.; Palmer, C. E.; Pariyadath, V; Paulus, M. P.; Pelham, W. E.; Pfefferbaum, D.; Pierpaoli, C.; Prescot, A.; Prouty, D.; Puttler, L., I; Rajapaske, N.; Rapuano, K. M.; Reeves, G.; Renshaw, P. F.; Riedel, M. C.; Rojas, P.; de la Rosa, M.; Rosenberg, M. D.; Ross, M. J.; Sanchez, M.; Schirda, C.; Schloesser, D.; Schulenberg, J.; Sher, K. J.; Sheth, C.; Shilling, P. D.; Simmons, W. K.; Sowell, E. R.; Speer, N.; Spittel, M.; Squeglia, L. M.; Sripada, C.; Steinberg, J.; Striley, C.; Sutherland, M. T.; Tanabe, J.; Tapert, S. F.; Thompson, W.; Tomko, R. L.; Uban, K. A.; Vrieze, S.; Wade, N. E.; Watts, R.; Weiss, S.; Wiens, B. A.; Williams, O. D.; Wilbur, A.; Wing, D.; Wolff-Hughes, D.; Yang, R.; Yurgelun-Todd, D. A.; Zucker, R. A.; Potter, A.; Garavan, H. P.
    The Adolescent Brain Cognitive Development (ABCD) Study(R) is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.
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    High prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension
    (1999) Mosso, L.; Fardella, C.; Montero, J.; Rojas, P.; Sanchez, O.; Rojas, V.; Rojas, A.; Huete, A.; Soto, J.; Foradori, A.; NCD Risk Factor Collaboration (NCD-RisC)
    Background: Classically, primary hyperaldosteronism was diagnosed in no more than 1% of patients with hypertension, when hypokalemia was used as the screening test. However, numerous patients with primary hyperaldosteronism do not have hypokalemia nod the disease remains undiagnosed. Aim: To assess the prevalence of normokalemic primary hyperaldosteronism among patients classified as having essential hypertension. Patients and methods: One hundred hypertensive patients with a blood pressure over 145/95 were studied. Plasma aldosterone and plasma renin activity were measured in all. A primary hyperaldosteronism was diagnosed when high aldosterone levels (over 16 ng/dl) and low plasma renin activity (below 0.5 ng/ml/h) coexisted in two blood tests of the aldosterone/plasma renin activity ratio was over 50. A probable primary hyperaldosteronism was diagnosed whet? the ratio was between 25 and 50 and these patients were subjected to a Fludrocortisone test to confirm the diagnosis. A dexametasone suppression test was done to discard glucocorticoid remediable aldosteronism. An adrenal TAC scan was done to all patients with primary hyperaldosteronism. Results: A diagnosis of primary hyperaldosteronism was reached in ten patients. Seven had elevated aldosterone and low plasma renin activity. In three the diagnosis was confirmed with the fludrocortisone test. All ten patients had normal serum potassium levels. Dexametasone suppression test was positive in three patients that normalized their blood pressure levels. Adrenal TAC scans showed an adenoma in one patient and hyperplasia in another. Conclusions: Primary hyperaldosteronism is more frequent than previously thought, it is overlooked when hypokalemia is used as the screening test and it can only be diagnosed measuring plasma aldosterone and renin activity.
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    Liver transplantation in hemophilia A. Report of one case
    (2019) Benítez, Carlos; Zuniga, P.; Kramer, F.; Valladares, X.; Rojas, P.; Pimentel, E.; Gomez, F.; Cancino, A.; Briceño, Eduardo; Guerra, J.F.; Martinez, J.
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    Low free testosterone levels predict disease reclassification in men with prostate cancer undergoing active surveillance
    (2014) San Francisco Reyes, Ignacio Felipe; Rojas, P.; Dewolf, W.; Morgentaler, A.
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    M-protein gene-type distribution and hyaluronic acid capsule in group A Streptococcus clinical isolates in Chile: association of emm gene markers with csrR alleles
    (CAMBRIDGE UNIV PRESS, 2012) Wozniak, A.; Rojas, P.; Rodriguez, C.; Undabarrena, A.; Garate, C.; Riedel, I.; Roman, J. C.; Kalergis, A. M.; Garcia, P.
    Streptococcus pyogenes causes a variety of infections because of virulence factors such as capsular hyaluronic acid and M protein. The aim of this study was to determine emm types and capsule phenotype in 110 isolates of S. pyogenes from patients with invasive (sterile sites) and non-invasive (mainly pharyngitis) infections in Chile, and the relationship between both virulence factors. The most abundant types found were emm12, emm1, emm4 and emm28 and their distribution was similar to that seen in Latin America and developed countries, but very different from that in Asia and Pacific Island countries. Ten of 16 emm types identified in pharyngeal isolates were found in sterile-site isolates, and three of nine emm types of sterile-site isolates occurred in pharyngeal isolates; three emm subtypes were novel. The amount of hyaluronic acid was significantly higher in sterile-site isolates but did not differ substantially among emm types. Only three isolates were markedly capsulate and two of them had mutations in the csrR gene that codes for a repressor of capsule synthesis genes. We found a non-random association between emm types and csrR gene alleles suggesting that horizontal gene transfer is not freely occurring in the population.
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    Mapa de corrosión atmosférica de Chile : resultados después de un año de exposición
    (2012) Vera, R.; Puentes, M.; Araya, R.; Rojas, P.; Carvajal Guerra, Ana María
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    Normokalemic primary hyperaldosteronism - A common cause of secondary hypertension
    (1999) Mosso, L.; Fardella, C.; Montero, J.; Rojas, P.; Sanchez, O.; Rojas, A.; Soto, J.; Foradori, A.; Huete, A.; NCD Risk Factor Collaboration (NCD-RisC)
    Recently, some genetic forms of hypertension have been well characterized. These forms can be globally called mineralocorticoid hypertension and are due to different alterations of the renin-angiotensin-aldosterone system (SRAA). Among these, classic primary hyperaldosteronism and its glucocorticoid remediable variety, in which hypertension is secondary to aldosterone production, must be considered. There are also conditions in which mineralocorticoid activity does not depend on aldosterone production. These conditions generate a hyporeninemic hyperaldosteronism, observed in Liddle syndrome, apparent mineralocorticoid hypertension, 11- and 17-hydroxilase deficiency, among others. The detection of these forms of hypertension is only feasible if the renin-angiotensin-aldosterone system is assessed, measuring renin and aldosterone levels. This article reviews these forms of hypertension, their clinical workup and their relevance in the usual hypertensive patients.
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    Partitioning beta-diversity reveals that invasions and extinctions promote the biotic homogenization of Chilean freshwater fish fauna
    (2020) Castro, Sergio A.; Rojas, P.; Vila, I.; Habit, E.; Pizarro-Konczak, J.; Abades T., Sebastián R.; Jaksic Andrade, Fabián
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    Powder Metallurgy Production of Ti-2 Wt Pct Si Alloy : Structural, Mechanical, and Electrochemical Characterization of the Sintered Material
    (2020) Guzman, D.; Muranda, D.; Soliz, A.; Aguilar, C.; Guzman, A.; Sancy, Mamié; Pineda Parra, Fabiola Makarena; Rojas, P.