Browsing by Author "Rojas, J."

Now showing 1 - 5 of 5
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    Association of bilateral oophorectomy and menopause hormone therapy with mild cognitive impairment: the REDLINC X study
    (2022) Blumel, J. E.; Arteaga, E.; Vallejo, M. S.; Ojeda, E.; Meza, P.; Martino, M.; Rodriguez-Vidal, D.; Nanez, M.; Tserotas, K.; Rojas, J.; Rodrigues, M. A.; Espinoza, M. T.; Salinas, C.; Parraga-Parraga, J.; Chedraui, P.
    Background Dementia is a major public health problem. Estrogen is a regulator of the central nervous system and its deficit could be involved in cognitive decline in older women. Objective This study aimed to evaluate the association of bilateral oophorectomy, menopause hormone therapy (MHT) and other factors on mild cognitive impairment (MCI). Method The case-control study included 941 otherwise healthy postmenopausal women aged 60 years and over from six Latin American countries. Personal and family data were recorded and MCI was assessed using the Montreal Cognitive Assessment test (MoCA). Results Average age, years of education and body mass index were 66.1 +/- 5.8 years, 12.4 +/- 5.0 years and 26.0 +/- 4.3 kg/m(2), respectively. A total of 30.2% had undergone bilateral oophorectomy and 40.3% had used MHT. A total of 232 women (24.7%) had MCI. The prevalence of MCI was higher in women with intact ovaries and non-MHT users as compared to MHT users (29.3% vs. 11.7% [odds ratio (OR) 0.32; 95% confidence interval (CI) 0.20-0.51]). Among oophorectomized women, MCI prevalence was higher among non-MHT users as compared to MHT users (45.2% vs. 12.8% [OR 0.18; 95% CI 0.10-0.32]). Logistic regression analysis determined that the variables associated with MCI were age >65 years (OR 1.69; 95% CI 1.20-2.38), parity (having >2 children; OR 1.69; 95% CI 1.21-2.37), bilateral oophorectomy (OR 1.56; 95% CI 1.09-2.24), hypertension (OR 1.41; 95% CI 1.01-1.96), being sexually active (OR 0.56; 95% CI 0.40-0.79), education >12 years (OR 0.46; 95% CI 0.32-0.65) and MHT use (OR 0.31; 95% CI 0.21-0.46). Conclusion Age, parity, bilateral oophorectomy and hypertension are independent factors associated with MCI; contrary to this, higher educational level, maintaining sexual activity and using MHT are protective factors.
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    Metformin use is associated with a lower risk of osteoporosis in adult women independent of type 2 diabetes mellitus and obesity. REDLINC IX study
    (2020) Blümel, J. E.; Arteaga U., Eugenio; Aedo, S.; Arriola Montenegro, J.; López, M.; Martino, M.; Miranda, C.; Miranda, O.; Mostajo, D.; Ñañez, M.; Ojeda, E.; Pilnik, S.; Rojas, J.; Salinas, C.; Sosa, L.; Spritzer, P. M.; Tserotas, K.; Vallejo, M. S.; Belardo, A.; Fighera, T. M.; Chedraui, P.
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    MyMOOCSpace: A Cloud-Based Mobile System to Support Effective Collaboration in Higher Education Online Courses,
    (2017) Ramirez, L.; Rojas, J.; Pérez Sanagustín, Mar; Neyem, Andrés; Alario, C.
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    The oldest record of the Lamini Tribe and Proboscidea order in the southwestern margin of the Andes Mountain range: Late Pleistocene mammalian footprints at the Pelluco fossil forest sanctuary
    (2022) Campos Medina, J.; Moreno, K.; Rojas, J.; Gomez, G.; Garcia, J-L; Buldrini, K. E.; Luthgens, C.; Rodriguez, E.; Alvarez, R.; Abarzua, A. M.
    Punta Pelluco is a known fossil forest locality near Puerto Montt in the province of Llanquihue, Southern Chile, which preserves exquisite palynological and xylological records of the last glacial period (Late Pleistocene), discoveries that have been made since 1978. The present investigation contributes the first Chilean record of camelid and proboscidean footprints, discovered in 2015 at Punta Pelluco. The ichnospecies identified are Lamaichnum guanicoe (average footprint 10.1 cm length, 9.9 cm width) and the largest Proboscipeda cf. P. australis (average 38 cm length, 38.2 cm width in the first footprint and average 41.8 cm length, 42.2 cm width in the second footprint) found in South America, respectively. These are the oldest Chilean records for Lamini and Proboscidea, dating back to between about 52.300 and 44.300 years ago. Not much is known about the dispersal of camelids and gomphotherids through the Andean Mountains after the Great American Biotic Interchange, but the present record status seems to indicate that the presence was restricted to the Pleistocene, at least 44,000 years ago.
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