Browsing by Author "Rojas, A."

Now showing 1 - 19 of 19
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    Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
    (2002) Mosso, L.; Carvajal, C.; Campino, C.; Rojas, A.; Gonzalez, A.; Barraza, A.; Montero, J.; Fardella, C.
    Background: Half of hypertensive patients with, low plasma renin activity have a primary hyperaldosteronism. Among the remaining half 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) deficiency plays all important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with, the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11betaSHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ug/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum. cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between, 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1 +/- 3.3 and 9.2 +/- 2.8 mug/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4 +/- 1.3 and 3.7 +/- 1.2 μg/dl, respectively). Four hypertensive subjects bad all abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with, low plasma renin activity and aldosterone had biochemical alterations suggestive of 11.1βHSD2 deficiency.
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    BASS. XLII. The Relation between the Covering Factor of Dusty Gas and the Eddington Ratio in Nearby Active Galactic Nuclei
    Ricci, C.; Ichikawa, K.; Stalevski, M.; Kawamuro, T.; Yamada, S.; Ueda, Y.; Mushotzky, R.; Privon, G. C.; Koss, M. J.; Trakhtenbrot, B.; Fabian, A. C.; Ho, L. C.; Asmus, D.; Bauer, Franz Erik; Chang, C. S.; Gupta, K. K.; Oh, K.; Powell, M.; Pfeifle, R. W.; Rojas, A.; Ricci, F.; Temple, M. J.; Toba, Y.; Tortosa, A.; Treister, Ezequiel; Harrison, F.; Stern, D.; Urry, C. M.
    Accreting supermassive black holes (SMBHs) located at the centers of galaxies are typically surrounded by large quantities of gas and dust. The structure and evolution of this circumnuclear material can be studied at different wavelengths, from the submillimeter to the X-ray. Recent X-ray studies have shown that the covering factor of the obscuring material tends to decrease with increasing Eddington ratio, likely due to radiative feedback on dusty gas. Here we study a sample of 549 nearby (z less than or similar to 0.1) hard X-ray (14-195 keV) selected nonblazar active galactic nuclei (AGN) and use the ratio between the AGN infrared and bolometric luminosity as a proxy of the covering factor. We find that, in agreement with what has been found by X-ray studies of the same sample, the covering factor decreases with increasing Eddington ratio. We also confirm previous findings that showed that obscured AGN typically have larger covering factors than unobscured sources. Finally, we find that the median covering factors of AGN located in different regions of the column density-Eddington ratio diagram are in good agreement with what would be expected from a radiation-regulated growth of SMBHs.
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    Consideraciones acerca de la “interrupción voluntaria del embarazo”, desde el punto de vista ético-médico (a propósito de un proyecto de ley)
    (2015) Echeverria, C.; Serani Merlo, Alejandro; Arriagada, A.; Goic, A.; Herrera, C.; Quintana Villar, Carlos; Rojas, A.; Ruiz, G.; Salinas, R.; Taboada R., Paulina; Vacarezza, R.
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    Does therapeutic privilege have a place in modern medicine?
    (2017) Salinas, R.; Echeverría, C.; Arriagada A.; Goic, A.; Quintana Villar, Carlos; Rojas, A.; Serani Merlo, Alejandro; Taboada R., Paulina; Vacarezza, R.
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    Genetic variation in P450c11AS in Chilean patients with low renin hypertension
    (ENDOCRINE SOC, 1996) Fardella, C.E.; Rodriguez, H.; Montero, J.; Zhang, G.R.; Vignolo, P.; Rojas, A.; Villarroel, L.; Miller, W.L.
    Low renin hypertension (LRH), which accounts for 10-20% of patients with idiopathic ''essential'' hypertension, bears hormonal similarities to mineralocorticoid-induced hypertension, but elevated mineralocorticoid concentrations have not been found. Some patients with LRH have normal, rather than suppressed, plasma aldosterone concentrations, so that the ratio of aldosterone concentration to PRA (Aldo/PRA) is high, suggesting inappropriately increased aldosterone biosynthesis. We characterized the CYP11B2 gene that encodes the aldosterone synthase, P450c11AS, in hypertensive and control populations in a single clinic in Santiago, Chile. We directly sequenced the entire CYP11B2 gene in 12 patients with LRH, 2 high renin hypertensive controls, and 2 normotensive controls. All sequences were identical, except that 8 of 24 LRH alleles encoded arginine rather than lysine at position 173. The Arg(173) and Lys(173) variants were expressed in transfected MA-10 cells, and their ability to convert deoxycorticosterone to aldosterone was measured; the apparent Michaelis constant (K-m) for Lys(173) was 2.73 mu mol/L; the K-m for Arg(173) was 2.53 mu mol/L. The apparent maximal velocity (V-max) for Lys(173) was 6.5x10(-3) mu g/mL . 24 h; the V-max for Arg(173) was 7.8x10(-3) mu g/mL . 24 h. The first order rate constant, V-max/K-m was 2.38 for Lys(173) and 3.08 for Arg(173). As these values were not significantly different, we sought to determine whether Arg(173) is a polymorphism linked to LRH. We examined position 173 in 52 unselected patients with idiopathic hypertension and 55 normotensive controls by PCR amplification of CYP11B2 exons 3-5 followed by digestion with Bsu36I, which digests the Arg(173) sequence, but not the Lys(173) sequence. More of the hypertensive alleles (39 of 104, 37.5%) than normotensive alleles (25 of 110, 22.5%) carried Arg(173) (chi(2)=5.57; P <0.02). Most of the Arg(173) alleles (31 of 72, 43.1%) were from hypertensive patients with Aldo/PRA below 30, whereas only 5 of 24 (20.8%) Arg(173) alleles were found in patients with Aldo/PRA greater than 30 (chi(2)=3.79; P=0.05) Thus, the Arg(173) variant of CYP11B2 may be linked to LRH in Chilean patients.
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    High prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension
    (1999) Mosso, L.; Fardella, C.; Montero, J.; Rojas, P.; Sanchez, O.; Rojas, V.; Rojas, A.; Huete, A.; Soto, J.; Foradori, A.; NCD Risk Factor Collaboration (NCD-RisC)
    Background: Classically, primary hyperaldosteronism was diagnosed in no more than 1% of patients with hypertension, when hypokalemia was used as the screening test. However, numerous patients with primary hyperaldosteronism do not have hypokalemia nod the disease remains undiagnosed. Aim: To assess the prevalence of normokalemic primary hyperaldosteronism among patients classified as having essential hypertension. Patients and methods: One hundred hypertensive patients with a blood pressure over 145/95 were studied. Plasma aldosterone and plasma renin activity were measured in all. A primary hyperaldosteronism was diagnosed when high aldosterone levels (over 16 ng/dl) and low plasma renin activity (below 0.5 ng/ml/h) coexisted in two blood tests of the aldosterone/plasma renin activity ratio was over 50. A probable primary hyperaldosteronism was diagnosed whet? the ratio was between 25 and 50 and these patients were subjected to a Fludrocortisone test to confirm the diagnosis. A dexametasone suppression test was done to discard glucocorticoid remediable aldosteronism. An adrenal TAC scan was done to all patients with primary hyperaldosteronism. Results: A diagnosis of primary hyperaldosteronism was reached in ten patients. Seven had elevated aldosterone and low plasma renin activity. In three the diagnosis was confirmed with the fludrocortisone test. All ten patients had normal serum potassium levels. Dexametasone suppression test was positive in three patients that normalized their blood pressure levels. Adrenal TAC scans showed an adenoma in one patient and hyperplasia in another. Conclusions: Primary hyperaldosteronism is more frequent than previously thought, it is overlooked when hypokalemia is used as the screening test and it can only be diagnosed measuring plasma aldosterone and renin activity.
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    Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms
    (2013) Serón Ferré, María; Forcelledo Hospital, M. Luisa; Torres Farfán, Claudia Lorena; Valenzuela, F.; Rojas, A.; Vergara Muñoz, Marcela; Rojas García, Pedro Pablo; Recabarren, Monica; Valenzuela, G.
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    Mendelian Randomization Analysis of the Relationship Between Native American Ancestry and Gallbladder Cancer Risk
    (2022) Zollner, L.; Boekstegers, F.; Ponce, C.B.; Scherer, D.; Marcelain, K.; Gárate-Calderón, V.; Waldenberger, M.; Morales, E.; Rojas, A.; Munoz, C.; Müller, B.; Retamales, J.; de Toro, G.; Kortmann, A.V.; Barajas, O.; Rivera, M.T.; Cortés, A.; Loader, D.; Saavedra, J.; Gutiérrez, L.; Ortega, A.; Bertrán, M.E.; Bartolotti, L.; Gabler, F.; Campos, M.; Alvarado, J.; Moisán, F.; Spencer, L.; Nervi Nattero, Bruno; Carvajal, D.; Losada, H.; Almau, M.; Fernández, P.; Olloquequi, J.; Carter, A.R.; Miquel, Juan Francisco; Bustos, B.I.; Guajardo, M.F.; Gonzalez-Jose, R.; Bortolini, M.C.; Acuña-Alonzo, V.; Gallo, C.; Linares, A.R.; Rothhammer, F.; Bermejo, J.L.
    Background A strong association between the proportion of Native American ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest Native American people in Chile. We set out to investigate the causal association between Native American Mapuche ancestry and GBC risk, and the possible mediating effects of gallstone disease and body mass index (BMI) on this association. Methods Markers of Mapuche ancestry were selected based on the informativeness for assignment measure and then used as instrumental variables in two-sample mendelian randomization (MR) analyses and complementary sensitivity analyses. Result We found evidence of a causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% for every 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.6×10-5). Mapuche ancestry was also causally linked to gallstone disease (IVW risk increase of 3.6% per 1% increase in Mapuche proportion, 95% CI 3.1% to 4.0%, p = 1.0×10-59), suggesting a mediating effect of gallstones in the relationship between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative causal effect on BMI (IVW estimate -0.006 kg/m2 per 1% increase in Mapuche proportion, 95% CI -0.009 to -0.003, p = 4.4×10-5). Conclusions The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between Mapuche ancestry and GBC risk previously noted in observational studies appears to be causal, primary and secondary prevention strategies that take into account the individual proportion of Mapuche ancestry could be particularly efficient.
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    Normokalemic primary hyperaldosteronism - A common cause of secondary hypertension
    (1999) Mosso, L.; Fardella, C.; Montero, J.; Rojas, P.; Sanchez, O.; Rojas, A.; Soto, J.; Foradori, A.; Huete, A.; NCD Risk Factor Collaboration (NCD-RisC)
    Recently, some genetic forms of hypertension have been well characterized. These forms can be globally called mineralocorticoid hypertension and are due to different alterations of the renin-angiotensin-aldosterone system (SRAA). Among these, classic primary hyperaldosteronism and its glucocorticoid remediable variety, in which hypertension is secondary to aldosterone production, must be considered. There are also conditions in which mineralocorticoid activity does not depend on aldosterone production. These conditions generate a hyporeninemic hyperaldosteronism, observed in Liddle syndrome, apparent mineralocorticoid hypertension, 11- and 17-hydroxilase deficiency, among others. The detection of these forms of hypertension is only feasible if the renin-angiotensin-aldosterone system is assessed, measuring renin and aldosterone levels. This article reviews these forms of hypertension, their clinical workup and their relevance in the usual hypertensive patients.
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    Phytoestrogens possess a weak antioxidant activity on low density lipoprotein in contrast to the flavonoid quercetin in vitro in postmenopausal women
    (TAYLOR & FRANCIS LTD, 2004) Arteaga U., Eugenio; Villaseca Délano, Paulina; Rojas, A.; Marshall Rivera, Guillermo; Bianchi, M.
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    Raloxifene is a better antioxidant of low-density lipoprotein than estradiol or tamoxifen in postmenopausal women in vitro
    (2003) Arteaga U., Eugenio; Villaseca Délano, Paulina; Bianchi Poblete, Marcelo Raúl; Rojas, A.; Marshall Rivera, Guillermo
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    Severe hyponatremia secondary to Phyllomedusa bicolor (Kambo frog) poisoning. Report of one case
    (2019) Campodónico, J.; Aedo, P.; Montane, M. I.; Rojas, A.; Aveiga, A.; Silva, L; Ríos Bustamante, Juan Carlos; Solís, I.
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    The VVV Survey of the Milky Way: first year results
    (2011) Minniti, D.; Clariá, J. J.; Saito, R. K.; Hempel, M.; Lucas, P. W.; Rejkuba, M.; Toledo, I.; Gonzalez, O. A.; Alonso-García, J.; Irwin, M. J.; Gonzalez-Solares, E.; Cross, N.; Ivanov, V. D.; Soto, M.; Dékány, I.; Angeloni, R.; Catelan, Marcio; Amôres, E. B.; Gurovich, S.; Emerson, J. P.; Lewis, J.; Hodgkin, S.; Pietrukowicz, P.; Zoccali, M.; Sale, S. E.; Barbá, R.; Barbuy, B.; Beamin, J. C.; Helminiak, K.; Borissova, J.; Folkes, S. L.; Gamen, R. C.; Geisler, D.; Mauro, F.; Chené, A. -N.; Alonso, M. V.; Gunthardt, G.; Hanson, M.; Kerins, E.; Kurtev, R.; Majaess, D.; Martín, E.; Masetti, N.; Mirabel, I. F.; Monaco, L.; Moni Bidin, C.; Padilla, N.; Rojas, A.; Pietrzynski, G.; Saviane, I.; Valenti, E.; Weidmann, W.; López-Corredoira, M.; Ahumada, A. V.; Aigrain, S.; Arias, J. I.; Bica, E.; Bandyopadhyay, R. M.; Baume, G.; Bedin, L. R.; Bonatto, C.; Bronfman, L.; Carraro, G.; Contreras, C.; Davis, C. J.; de Grijs, R.; Dias, B.; Drew, J. E.; Fariña, C.; Feinstein, C.; Fernández Lajús, E.; Gieren, W.; Goldman, B.; Gosling, A.; Hambly, N. C.; Hoare, M.; Jordán, A.; Kinemuchi, K.; Maccarone, T.; Merlo, D. C.; Mennickent, R. E.; Morelli, L.; Motta, V.; Palma, T.; Popescu, B.; Parisi, M. C.; Parker, Q.; Pignata, G.; Read, M. A.; Ruiz, M. T.; Roman-Lopes, A.; Schreiber, M. R.; Schröder, A. C.; Smith, M.; Sodré, L., Jr.; Stephens, A. W.; Walton, N. A.; Zijlstra, A. A.; Tamura, M.; Tappert, C.; Thompson, M. A.; Vanzi, L.
    The VISTA Variables in the Via Lactea (VVV) is an ESO public near-IR variability survey that is scanning the Milky Way bulge and an adjacent section of the Galactic mid-plane. The survey will take 1929 hours of observations with the VISTA 4.1-m telescope during five years, covering a billion point sources across an area of 520 sqdeg, including 36 known globular clusters and more than 350 open clusters. The final product will be a deep IR atlas in five passbands (0.9 - 2.5 microns) and a catalogue of more than a million variable point sources....
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    The VVV Survey: New Results (Part I)
    (2014) Minniti, D.; Saito, R. K.; Hempel, M.; Lucas, P. W.; Rejkuba, M.; Toledo, I.; Gonzalez, O. A.; Alonso-García, J.; Irwin, M. J.; Gonzalez-Solares, E.; Hodgkin, S. T.; Lewis, J. R.; Cross, N.; Ivanov, V. D.; Kerins, E.; Emerson, J. P.; Soto, M.; Amôres, E. B.; Gurovich, S.; Dékány, I.; Angeloni, R.; Beamin, J. C.; Catelan, Marcio; Padilla, N.; Zoccali, M.; Pietrukowicz, P.; Moni Bidin, C.; Mauro, F.; Geisler, D.; Folkes, S. L.; Sale, S. E.; Borissova, J.; Kurtev, R.; Ahumada, A. V.; Alonso, M. V.; Adamson, A.; Arias, J. I.; Bandyopadhyay, R. M.; Barbá, R. H.; Barbuy, B.; Baume, G. L.; Bedin, L. R.; Benjamin, R.; Bica, E.; Bonatto, C.; Bronfman, L.; Carraro, G.; Chenè, A. N.; Clariá, J. J.; Clarke, J. R. A.; Contreras, C.; Corvillón, A.; de Grijs, R.; Dias, B.; Drew, J. E.; Fariía, C.; Feinstein, C.; Fernández-Lajús, E.; Gamen, R. C.; Gieren, W.; Goldman, B.; González-Fernández, C.; Grand, R. J. J.; Gunthardt, G.; Hambly, N. C.; Hanson, M. M.; Helminiak, K.; Hoare, M. G.; Huckvale, L.; Jordán, A.; Kinemuchi, K.; Longmore, A.; López-Corredoira, M.; Maccarone, T.; Majaess, D.; Martín, E.; Masetti, N.; Mennickent, R. E.; Mirabel, I. F.; Monaco, L.; Morelli, L.; Motta, V.; Palma, T.; Parisi, M. C.; Parker, Q.; Peñaloza, F.; Pietrzyński, G.; Pignata, G.; Popescu, B.; Read, M. A.; Rojas, A.; Roman-Lopes, A.; Ruiz, M. T.; Saviane, I.; Schreiber, M. R.; Schröder, A. C.; Sharma, S.; Smith, M. D.; Sodré, L.; Stead, J.; Stephens, A. W.; Tamura, M.; Tappert, C.; Thompson, M. A.; Valenti, E.; Vanzi, L.; Walton, N. A.; Weidmann, W.; Zijlstra, A.
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    The VVV Survey: New Results (Part II)
    (2014) Minniti, D.; Saito, R. K.; Hempel, M.; Lucas, P. W.; Rejkuba, M.; Toledo, I.; Gonzalez, O. A.; Alonso-García, J.; Irwin, M. J.; Gonzalez-Solares, E.; Hodgkin, S. T.; Lewis, J. R.; Cross, N.; Ivanov, V. D.; Kerins, E.; Emerson, J. P.; Soto, M.; Amôres, E. B.; Gurovich, S.; Dékány, I.; Angeloni, R.; Beamin, J. C.; Catelan, Marcio; Padilla, N.; Zoccali, M.; Pietrukowicz, P.; Moni Bidin, C.; Mauro, F.; Geisler, D.; Folkes, S. L.; Sale, S. E.; Borissova, J.; Kurtev, R.; Ahumada, A. V.; Alonso, M. V.; Adamson, A.; Arias, J. I.; Bandyopadhyay, R. M.; Barbá, R. H.; Barbuy, B.; Baume, G. L.; Bedin, L. R.; Benjamin, R.; Bica, E.; Bonatto, C.; Bronfman, L.; Carraro, G.; Chenè, A. N.; Clariá, J. J.; Clarke, J. R. A.; Contreras, C.; Corvillón, A.; de Grijs, R.; Dias, B.; Drew, J. E.; Fariña, C.; Feinstein, C.; Fernández-Lajús, E.; Gamen, R. C.; Gieren, W.; Goldman, B.; González-Fernández, C.; Grand, R. J. J.; Gunthardt, G.; Hambly, N. C.; Hanson, M. M.; Helminiak, K.; Hoare, M. G.; Huckvale, L.; Jordán, A.; Kinemuchi, K.; Longmore, A.; López-Corredoira, M.; Maccarone, T.; Majaess, D.; Martín, E.; Masetti, N.; Mennickent, R. E.; Mirabel, I. F.; Monaco, L.; Morelli, L.; Motta, V.; Palma, T.; Parisi, M. C.; Parker, Q.; Peñaloza, F.; Pietrzyński, G.; Pignata, G.; Popescu, B.; Read, M. A.; Rojas, A.; Roman-Lopes, A.; Ruiz, M. T.; Saviane, I.; Schreiber, M. R.; Schröder, A. C.; Sharma, S.; Smith, M. D.; Sodré, L.; Stead, J.; Stephens, A. W.; Tamura, M.; Tappert, C.; Thompson, M. A.; Valenti, E.; Vanzi, L.; Walton, N. A.; Weidmann, W.; Zijlstra, A.
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    VISTA Variables in the Via Lactea (VVV): Current Status and First Results
    (2010) Saito, R.; Hempel, M.; Alonso-García, J.; Toledo, I.; Borissova, J.; González, O.; Beamin, J. C.; Minniti, D.; Lucas, P.; Emerson, J.; Ahumada, A.; Aigrain, S.; Alonso, M. V.; Amôres, E.; Angeloni, R.; Arias, J.; Bandyopadhyay, R.; Barbá, R.; Barbuy, B.; Baume, G.; Bedin, L.; Bica, E.; Bronfman, L.; Carraro, G.; Catelan, Marcio; Clariá, J.; Contreras, C.; Cross, N.; Davis, C.; de Grijs, R.; Dékány, I.; Janet Drew, J. D.; Fariña, C.; Feinstein, C.; Fernández Lajús, E.; Folkes, S.; Gamen, R.; Geisler, D.; Gieren, W.; Goldman, B.; Gosling, A.; Gunthardt, G.; Gurovich, S.; Hambly, N.; Hanson, M.; Hoare, M.; Irwin, M.; Ivanov, V.; Jordán, A.; Kerins, E.; Kinemuchi, K.; Kurtev, R.; Longmore, A.; López-Corredoira, M.; Maccarone, T.; Martín, E.; Masetti, N.; Mennickent, R.; Merlo, D.; Messineo, M.; Mirabel, F.; Monaco, L.; Moni Bidin, C.; Morelli, L.; Padilla, N.; Palma, T.; Parisi, M. C.; Parker, Q.; Pavani, D.; Pietrukowicz, P.; Pietrzynski, G.; Pignata, G.; Rejkuba, M.; Rojas, A.; Roman Lopes, A.; Ruiz, M. T.; Sale, S.; Saviane, I.; Schreiber, M.; Schröder, A.; Sharma, S.; Smith, M.; Sodré, L., Jr.; Soto, M.; Stephens, A.; Tamura, M.; Tappert, C.; Thompson, M.; Valenti, E.; Vanzi, L.; Weidmann, W.; Zoccali, M.
    VISTA Variables in the Vía Láctea (VVV) is a public ESO near-IR variability survey aimed at scanning the Milky Way Bulge and an adjacent section of the mid-plane. VVV observations started in October 2009 during ESO science verification. Regular observations for the first year of the survey have been conducted since February 2010 and will cover a total area of 520 square degrees in five passbands and five epochs. Here we address the first results obtained from the VVV Survey as well as the current status of the observations....
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    VISTA Variables in the Vía Láctea (VVV): Halfway Status and Results
    (2014) Hempel, M.; Minniti, D.; Dékány, I.; Saito, R. K.; Lucas, P. W.; Emerson, J. P.; Ahumada, A. V.; Aigrain, S.; Alonso, M. V.; Alonso-García, J.; Amôres, E. B.; Angeloni, R.; Arias, J.; Bandyopadhyay, R.; Barbá, R. H.; Barbuy, B.; Baume, G.; Beamin, J. C.; Bedin, L.; Bica, E.; Borissova, J.; Bronfman, L.; Carraro, G.; Catelan, Marcio; Clariá, J. J.; Contreras, C.; Cross, N.; Davis, C.; de Grijs, R.; Drew, J. E.; Fariña, C.; Feinstein, C.; Fernández-Lajús, E. F.; Folkes, S.; Gamen, R. C.; Geisler, D.; Gieren, W.; Goldman, B.; González, O.; Gosling, A.; Gunthardt, G.; Gurovich, S.; Hambly, N. C.; Hanson, M.; Hoare, M.; Irwin, M. J.; Ivanov, V. D.; Jordán, A.; Kerins, E.; Kinemuchi, K.; Kurtev, R.; Longmore, A.; López-Corredoira, M.; Maccarone, T.; Martín, E.; Masetti, N.; Mennickent, R. E.; Merlo, D.; Messineo, M.; Mirabel, I. F.; Monaco, L.; Moni-Bidin, C.; Morelli, L.; Padilla, N.; Palma, T.; Parisi, M. C.; Parker, Q.; Pavani, D.; Pietrukowicz, P.; Pietrzynski, G.; Pignata, G.; Rejkuba, M.; Rojas, A.; Roman-Lopes, A.; Ruiz, M. T.; Sale, S. E.; Saviane, I.; Schreiber, M. R.; Schröder, A. C.; Sharma, S.; Smith, M.; Sodré, L., Jr.; Soto, M.; Stephens, A. W.; Tamura, M.; Tappert, C.; Thompson, M. A.; Toledo, I.; Valenti, E.; Vanzi, L.; Weidmann, W.; Zoccali, M.
    The VISTA Variables in the Vía Láctea (VVV) survey is one of six near-infrared ESO public surveys, and is now in its fourth year of observing. Although far from being complete, the VVV survey has already delivered many results, some directly connected to the intended science goals (detection of variable stars, microlensing events, new star clusters), others concerning more exotic objects, e.g., novae. Now, at the end of the fourth observing period, and comprising roughly 50% of the proposed observations, the status of the survey, as well some of results based on the VVV data, are presented....
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    VVV DR1: The first data release of the Milky Way bulge and southern plane from the near-infrared ESO public survey VISTA variables in the Via Lactea
    (EDP SCIENCES S A, 2012) Saito, R. K.; Hempel, M.; Minniti, D.; Lucas, P. W.; Rejkuba, M.; Toledo, I.; Gonzalez, O. A.; Alonso Garcia, J.; Irwin, M. J.; Gonzalez Solares, E.; Hodgkin, S. T.; Lewis, J. R.; Cross, N.; Ivanov, V. D.; Kerins, E.; Emerson, J. P.; Soto, M.; Amores, E. B.; Gurovich, S.; Dekany, I.; Angeloni, R.; Beamin, J. C.; Catelan, M.; Padilla, N.; Zoccali, M.; Pietrukowicz, P.; Bidin, C. Moni; Mauro, F.; Geisler, D.; Folkes, S. L.; Sale, S. E.; Borissova, J.; Kurtev, R.; Ahumada, A. V.; Alonso, M. V.; Adamson, A.; Arias, J. I.; Bandyopadhyay, R. M.; Barba, R. H.; Barbuy, B.; Baume, G. L.; Bedin, L. R.; Bellini, A.; Benjamin, R.; Bica, E.; Bonatto, C.; Bronfman, L.; Carraro, G.; Chene, A. N.; Claria, J. J.; Clarke, J. R. A.; Contreras, C.; Corvillon, A.; de Grijs, R.; Dias, B.; Drew, J. E.; Farina, C.; Feinstein, C.; Fernandez Lajus, E.; Gamen, R. C.; Gieren, W.; Goldman, B.; Gonzalez Fernandez, C.; Grand, R. J. J.; Gunthardt, G.; Hambly, N. C.; Hanson, M. M.; Helminiak, K. G.; Hoare, M. G.; Huckvale, L.; Jordan, A.; Kinemuchi, K.; Longmore, A.; Lopez Corredoira, M.; Maccarone, T.; Majaess, D.; Martin, E. L.; Masetti, N.; Mennickent, R. E.; Mirabel, I. F.; Monaco, L.; Morelli, L.; Motta, V.; Palma, T.; Parisi, M. C.; Parker, Q.; Penaloza, F.; Pietrzynski, G.; Pignata, G.; Popescu, B.; Read, M. A.; Rojas, A.; Roman Lopes, A.; Ruiz, M. T.; Saviane, I.; Schreiber, M. R.; Schroeder, A. C.; Sharma, S.; Smith, M. D.; Sodre, L., Jr.; Stead, J.; Stephens, A. W.; Tamura, M.; Tappert, C.; Thompson, M. A.; Valenti, E.; Vanzi, L.; Walton, N. A.; Weidmann, W.; Zijlstra, A.
    Context. The ESO public survey VISTA variables in the Via Lactea (VVV) started in 2010. VVV targets 562 sq. deg in the Galactic bulge and an adjacent plane region and is expected to run for about five years.