Browsing by Author "Rodriguez, Pablo"

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    Mutational Landscape and Actionable Target Rates on Advanced Stage Refractory Cancer Patients: A Multicenter Chilean Experience
    (2022) Cordova-Delgado, Miguel; Pinto, Mauricio P.; Regonesi, Carlos; Cereceda, Luis; Reyes, Jose Miguel; Itriago, Laura; Majlis, Alejandro; Rodriguez, Pablo; Fassler, Andre; Mahave, Mauricio; Leon, Maria Elisa; Gallardo, Jorge; Rodriguez, Maria Paz Z.; Berkovits, Alejandro; Manque, Patricio; Rios, Juvenal A.; Garcia-Bloj, Benjamin; Garrido, Marcelo
    Major advances in sequencing technologies and targeted therapies have accelerated the incorporation of oncology into the era of precision medicine and "biomarker-driven" treatments. However, the impact of this approach on the everyday clinic has yet to be determined. Most precision oncology reports are based on developed countries and usually involve metastatic, hard-to-treat or incurable cancer patients. Moreover, in many cases race and ethnicity in these studies is commonly unreported and real-world evidence in this topic is scarce. Herein, we report data from a total of 202 Chilean advanced stage refractory cancer patients. Retrospectively, we collected patient data from NGS tests and IHC in order to determine the proportion of patients that would benefit from targeted treatments. Overall >20 tumor types were included in our cohort and 37% of patients (n = 74) displayed potentially actionable alterations, including on-label, off-label and immune checkpoint inhibitor recommendations. Our findings were in-line with previous reports such as the cancer genome atlas (TCGA). To our knowledge, this is the first report of its kind in Latin America delivering real-world evidence to estimate the percentage of refractory tumor patients that might benefit from precision oncology. Although this approach is still in its infancy in Chile, we strongly encourage the implementation of mutational tumor boards in our country in order to provide more therapeutic options for advanced stage refractory patients.
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    Parameterization proposal to determine the feasibility of geographic areas for the green hydrogen industry under socio-environmental and technical constraints in Chile
    (2024) San Martin, Marco; Poch, Paola; Carmona, Roberto; Rodriguez, Pablo; Rodriguez, Angel; Serafini, Daniel; Garrido, Rene; Mena, Marcelo; Valdes, Javier; Masip, Yunesky
    Chile, abundant in solar and wind energy resources, presents significant potential for the production of green hydrogen, a promising renewable energy vector. However, realizing this potential requires an understanding of the most suitable locations for the installation of green hydrogen industries. This study proposes a quantitative methodology that identifies and ranks potential public lands for industrial use, based on a range of technical parameters (such as solar and wind availability) and socio-environmental considerations (including land use restrictions and population density). The results reveal optimal locations that can facilitate informed, sustainable decision-making for large-scale green hydrogen implementation in Chile. While this methodology does not replace project specific technical or environmental impact studies, it provides a flexible, general classification to guide initial site selection. Notably, this approach can be applied to other regions worldwide with abundant solar and wind resources, such as Australia and Northern Africa,