Browsing by Author "Rodriguez, A"

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    Dendritic morphology and orientation of pyramidal cells of the neocortex in two groups of early postnatal undernourished-rehabilitated rats
    (2003) Cordero, ME; Valenzuela, CY; Rodriguez, A; Aboitiz, F
    Postnatal undernutrition in animals and in humans leads to significant reduction in basal dendritic arborization of layer Vth pyramidal cells of the neocortex. Under the hypothesis that there are critical developmental periods for undernutrition to produce alterations in dendritic differentiation, we studied apical dendritic morphology and orientation of pyramidal cells from the deeper layers of the neocortex in rats undernourished until day 10 (UP10), until weaning (UP21) and in a control group (Q. Neurons were stained by the Golgi-Cox method. The main findings are: (i) an increased number of atypically oriented pyramids with apical dendrites extremely short in (UP10) and (UP21) groups and, (ii) the presence of classical pyramids with significantly longer apical dendrites in layers V and VI in (UP10) and (UP21) groups than in the control group (Q. We believe that undernutrition may disturb critically the early postnatal brain development by altering intrinsic factors and extracellular molecular signals that guide and regulate the apical dendritic growth of neocortex large pyramidal cells. (C) 2003 Elsevier Science B.V. All rights reserved.
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    Human Raphe Magnus Nucleus: a morphometric Golgi-Cox study with emphasis on sex differences
    (2001) Cordero, ME; Rodriguez, A; Torres, R; Valenzuela, CY
    The number and proportion of neurons according to their type and size in the Raphe Magnus Nucleus stained by the Golgi-Cox and Nissl methods were compared in male and female infants. Four female/male pairs aged from 2 to 150 days were studied. Wale females showed more neurons than males, males showed a higher proportion of large multipolar (more than 40 mum) and fusiform neurons (more than 20 mum) but not of ovoid neurons (more than 15 mum). These differences varied according to the type of cells and age of infants. Some of these results are similar to those found in the human Median Raphe Nucleus with the same methods. (C) 2001 Elsevier Science B.V. All rights reserved.
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    Sexual dimorphism in number and proportion of neurons in the human median raphe nucleus
    (ELSEVIER, 2000) Cordero, ME; Valenzuela, CY; Torres, R; Rodriguez, A
    The number and proportion of neurons in the median raphe nuclei stained by the Golgy-Cox and Nissl methods was compared in males and females infants. When subjects are matched by age and cause of death the number and proportion of fusiform, ovoid and multipolar cells differs significantly between sexes at different ages. (C) 2000 Elsevier Science B.V. All rights reserved.
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    Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice
    (W B SAUNDERS CO, 2000) Zanlungo, S; Amigo, L; Mendoza, H; Miquel, JF; Vio, C; Glick, JM; Rodriguez, A; Kozarsky, K; Quinones, V; Rigotti, A; Nervi, F
    Background & Aims: Sterol carrier protein 2 (SCP-2) enhances sterol cycling and facilitates cholesterol translocation between intracellular organelles and plasma membrane in cultured cells, including hepatocytes. We examined the role of SCP-2 in hepatic cholesterol and lipid trafficking through the sinusoidal and canalicular secretory pathways of the liver in vivo. Methods: Recombinant adenovirus-mediated SCP-2 gene transfer was used to obtain hepatic overexpression of SCP-2 in C57BL/6 mice. Results: SCP-2 overexpression in the mouse liver resulted in an 8-fold increase of SCP-2 protein levels and determined various effects on lipid metabolism. It decreased high-density lipoprotein cholesterol and increased low-density lipoprotein (LDL) cholesterol concentrations. The expressions of hepatic LDL receptor, apolipoprotein (apo) A-I, apoB, and apoE were decreased. SCP-2 overexpression also increased hepatic cholesterol concentration, associated with decreased cholesterol neosynthesis. Increased biliary cholesterol and bile acid secretion, bile acid pool size, and intestinal cholesterol absorption were also observed. Conclusions: These results indicate that modulation of SCP-2 expression in the liver determines important modifications on lipoprotein metabolism, hepatic cholesterol synthesis and storage, biliary lipid secretion, bile acid metabolism and intestinal cholesterol absorption.
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    Traumatic and nontraumatic perforation of hollow viscera
    (1997) Espinoza, R; Rodriguez, A
    Hollow viscus injuries are usually managed with few complications. However, if their diagnosis is delayed, or if reparative suture closure should fail, the patient is placed at risk of multiple organ failure. This article presents diagnostic approaches, emphasizing imaging modalities, and therapeutic strategies for three clinical scenarios of hollow viscus perforation: 1) acute appendicitis, 2) gastroduodenal peptic ulcer disease, and 3) trauma.