Browsing by Author "Rodrigo, Gustavo Javier"
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- ItemEfficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: A systematic review(2011) Rodrigo, Gustavo Javier; Neffen, Hugo E.; Castro Rodríguez, José Antonio
- ItemEfficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: A systematic review with meta-analysis(2009) Castro Rodríguez, José Antonio; Rodrigo, Gustavo Javier
- ItemFormoterol for acute asthma in the emergency department: a systematic review with meta-analysis(2010) Rodrigo, Gustavo Javier; Neffen, Hugo E.; Colodenco, Federico Daniel; Castro Rodríguez, José Antonio
- ItemGuía ALERTA 2. América Latina y España: Recomendaciones para la prevención y el tratamiento de la exacerbación asmática(2010) Rodrigo, Gustavo Javier; Plaza Moral, V.; Forns, Santiago Bardagí; Castro Rodríguez, José Antonio; De Diego Damiá, Alfredo; Cortés, Santos Liñán; Melero-Moreno, Carlos; Nannini, Luís Javier; Neffen, Hugo E.; Salas, Jorge Del Diego
- ItemHeliox-driven ß2-agonists nebulization for children and adults with acute asthma : A systematic review with meta-analysis(2014) Rodrigo, Gustavo Javier; Castro Rodríguez, José AntonioBackground The effect of heliox as a nebulizer β2-agonist driving gas in acute asthma remains controversial. Objective To perform a systematic review with a meta-analysis of randomized trials designed to evaluate the efficacy of heliox versus oxygen in driving β2-agonist nebulization in patients with acute asthma. Methods A search was conducted of all randomized controlled trials published before August 2013. Primary outcomes were change in spirometric measurements and severity composite score (pediatric studies); secondary outcomes were hospitalizations and serious adverse effects. Results Eleven trials from 10 studies (697 participants) met the inclusion criteria (7 included adults and 3 included children). The mean duration of heliox therapy was 120 minutes and the most common helium-oxygen mixture used was 70:30. Patients receiving heliox presented a statistically significant difference for mean percentage of change in peak expiratory flow (17.2%; 95% confidence interval 5.2-29.2, P =.005). Post hoc subgroup analysis showed that patients with severe and very severe asthma showed a significant improvement in peak expiratory flow compared with those with mild to moderate acute asthma. Heliox-driven nebulization also produced significant decreases in the risk of hospitalizations (odds ratio 0.49, 95% confidence interval 0.31-0.79, P =.003) and severity of exacerbations (pediatric studies; standard mean difference -0.74, 95%% confidence interval -1.45 to -0.03, P =.04). There were no group differences for serious adverse effects. Conclusion This review suggests that heliox benefits in airflow limitation and hospital admissions could be considered clinically significant. Data support the use of heliox as a nebulizing β2-agonist driving gas in the routine care of patients with acute asthma.
- ItemSafety and efficacy of combined long-acting β-agonists and inhaled corticosteroids vs long-acting β-agonists monotherapy for stable COPD: A systematic review(2009) Rodrigo, Gustavo Javier; Castro Rodríguez, José Antonio; Plaza, Vicente
- ItemThe role of inhaled corticosteroids and montelukast in children with mild-moderate asthma: Results of a systematic review with meta-analysis(2010) Castro Rodríguez, José Antonio; Rodrigo, Gustavo Javier
- ItemTiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: Systematic review with meta-analysis(2009) Rodrigo, Gustavo Javier; Castro Rodríguez, José Antonio; Nannini, Luís Javier; Plaza Moral, Vicente; Schiavi, Eduardo A.