Browsing by Author "Rodríguez, Fernando"

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    Co-occurrence of Noonan and Cardiofaciocutaneous Syndrome Features in a Patient with KRAS Variant
    (2018) Rodríguez, Fernando; Vallejos, Carla; Bolanos García, Víctor M.; Ponce, Diana; Unanue, Nancy; Garay Greve, Francisco Javier; Cassorla, Fernando; Aracena Álvarez, Mariana Inés
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    Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche
    (2023) Ponce, Diana; Rodríguez, Fernando; Miranda, José P.; Binder, Alexandra M.; Santos, José L.; Michels, Karin B.; Cutler, Gordon B.; Pereira, Ana; Iñiguez, Germán; Mericq, Verónica
    Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyper-insulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown. Epigenetic modifications, and specifi-cally DNA methylation, have been associated with the initiation and progression of numerous disorders, including obesity and insulin resistance. The aim of this study was to determine if prepubertal androgen exposure is associated with a different methylation profile in pubertal girls. Eighty-six healthy girls were studied. At age 7 y, anthropometric measurements were begun and DHEAS levels were determined. Girls were classified into Low DHEAS (LD) [<42 μg/dL] and High DHEAS (HD) [≥42 μg/dL] groups. At Tanner stages 2 and 4 a DNA methylation microarray was performed to identify differentially methylated CpG positions (DMPs) between HD and LD groups. We observed a differential methylation pattern between pubertal girls with and without bio-chemical PA. Moreover, a set of DNA methylation markers, selected by the LASSO method, successfully distinguished between HD and LD girls regardless of Tanner stage. Additionally, a subset of these markers were significantly associated with glucose-related measures such as insulin level, HOMA-IR, and glycaemia. This pilot study provides evidence consistent with the hypothesis that high DHEAS concentration, or its hormonally active metabolites, may induce a unique blood methylation signature in pubertal girls, and that this methylation pattern is associated with altered glucose metabolism.
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    Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O2 extraction during septic shock
    (2017) Ospina-Tascón, Gustavo A.; García Marín, Alberto F.; Echeverri, Gabriel J.; Bermúdez, William F.; Madriñán-Navia, Humberto; Valencia, Juan David; Quiñones, Edgardo; Rodríguez, Fernando; Bruhn, Alejandro; Hernández P., Glenn; Marulanda, Angela; Arango-Dávila, César A.; De Backer, Daniel
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    Factores asociados a sedentarismo en Chile : evidencia de la Encuesta Nacional de Salud 2009-2010
    (2018) Martínez, María Adela; Leiva, Ana María; Petermann, Fanny; Garrido, Alex; Díaz, Ximena; Álvarez, Cristián; Salas Bravo, Carlos; Cristi, Carlos; Rodríguez, Fernando; Aguilar, Nicolás; Ramírez, Rodrigo; Celis, Carlos
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