Browsing by Author "Roa Strauch, Juan Carlos Enrique"
Now showing 1 - 20 of 49
Results Per Page
Sort Options
- ItemAKT/mTOR substrate p70S6k is frequently phosphorylated in gallbladder cancer tissue and cell lines(2013) Leal, Pamela; García Cañete, Patricia; Sandoval, Alejandra; Buchegger, Kurt; Weber, Helga; Tapia, Oscar; Roa Strauch, Juan Carlos Enrique
- ItemAngiotensin-(1-9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway(2020) Sotomayor-Flores, C.; Rivera-Mejias, P.; Vasquez-Trincado, C.; Lopez-Crisosto, C.; Morales, P. E.; Pennanen, C.; Polakovicova, Iva; Roa Strauch, Juan Carlos Enrique; Ocaranza, María Paz; Corvalán R., Alejandro; Aliaga-Tobar, V.; Garcia, L.; Rothermel, B. A.; Maracaja-Coutinho, V.; Ho-Xuan, H.; Meister, G.; Chiong, M.; Parra, V.; Lavandero, S.
- ItemAssociation of inflammatory and other immune markers with gallbladder cancer : Results from two independent case-control studies(2016) Pinto, L.; Koshiol, J.; Castro, F.; Kemp, T.; Gao, Y.; Roa Strauch, Juan Carlos Enrique; Wang, B.; Nogueira, L.; Araya, J.; Ferreccio Readi, Catterina; Rashid, A.; Hsing, A.; Hildesheim, A.; Shen, M.; Pfeiffer, R.
- ItemCalcium calmodulin dependent kinase kinase 2-a novel therapeutic target for gastric adenocarcinoma(2015) Subbannayya, Yashwanth; Syed, Nazia; Barbhuiya, Mustafa A.; Roa Strauch, Juan Carlos Enrique; Marimuthu, Arivusudar; Sahasrabuddhe, Nandini; Pinto, Sneha M.; Manda, Srikanth Srinivas; Renuse, Santosh; Manju, HC; Zameer, Mohammed Abdul Lateef; Sharma, Jyoti; Brait, Mariana; Srikumar, Kotteazeth; Raja, Remya; Vijaya Kumar, M.; Kumar, KV Veerendra; Prasad, TS Keshava; Ramaswamy, Girija; Kumar, Rekha Vijay; Pandey, Akhilesh; Gowda, Harsha; Chatterjee, Aditi
- ItemCanonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth(2020) Chervo, M. F.; Russo, R. I. C.; Petrillo, E.; Izzo, F.; De Martino, M.; Bellora, N.; Cenciarini, M. E.; Chiauzzi, V. A.; de la Parra, L. S.; Roa Strauch, Juan Carlos Enrique; Pereyra, M. G.; Guttlein, L. N.; Podhajcer, O. L.; Daniotti, J. L.; Dupont, A.; Barchuk, S.; Figurelli, S.; Della Vecchia, D. L.; Guzman, P.; Proietti, C. J.; Schillaci, R.; Elizalde, P. V.
- ItemCellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression(2013) Ili, Carmen Gloria; Brebi, Priscilla; Tapia, Oscar; Sandoval, Alejandra; López, Jaime; García Muñoz, Patricia; Leal, Pamela; Sidransky, David; Guerrero Preston, Rafael; Roa Strauch, Juan Carlos Enrique
- ItemDifferential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?(2018) Urra, Soledad; Fischer, Martin C.; Martinez, Jose R.; Veliz, Loreto; Orellana, Paulina; Solar González, Antonieta Alejandra; Bohmwald Prieto, Karen; Kalergis Parra, Alexis Mikes; Riedel, Claudia; Corvalán R., Alejandro; Roa Strauch, Juan Carlos Enrique; Fuentealba, Rodrigo; Cáceres, C. Joaquín; López Lastra, Marcelo Andrés; León Ramírez, Augusto; Droppelmann, Nicolás; Gonzalez, Hernan E.
- ItemEarly gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor(2013) Roa Strauch, Juan Carlos Enrique; Tapia,Oscar; Manterola, Carlos; Villaseca, Miguel; Guzmán, Pablo; Araya, Juan Carlos; Bagci, Pelin; Saka, Burcu; Adsay, Volkan
- ItemEffects of c-FLIPL Knockdown in Cervical Uterine Carcinoma Cell Lines(2015) Ili, Carmen G.; Brebi, Priscilla; García Cañete, Patricia; Leal, Pamela; Lopez, Jaime; Tapia, Oscar; Letelier, Pablo; Weber, Helga; Castillo, Jonathan; Roa Strauch, Juan Carlos Enrique
- ItemEmerging Role of miRNAs in the Drug Resistance of Gastric Cancer(2016) Riquelme, I.; Letelier, P.; Riffo, A.; Brebi, P.; Roa Strauch, Juan Carlos Enrique
- ItemEvaluation of DNA methylation in promoter regions of SFRP4 and ZAR1 in urine and plasma of women with cervical lesions(2017) Hoffstetter, Rene; Riquelme, Ismael; Andana, Alejandra; Ili, Carmen G.; Buchegger, Kurt; Vargas, Hernan; Brebi, Priscilla; Roa Strauch, Juan Carlos Enrique
- ItemEvaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer : exploratory study phase I(2014) Brebi, P.; Hoffstetter, R.; Andana, A.; Ili, C.G.; Saavedra, K.; Viscarra, T.; Retamal, J.; Sanchez, R.; Roa Strauch, Juan Carlos Enrique
- ItemExosomes in bile as potential pancreatobiliary tumor biomarkers(2017) Sagredo, A.; Sepulveda, S.; Roa Strauch, Juan Carlos Enrique; Orostica, L.
- ItemExploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile(2023) Reyes, María Elena; Zanella, Louise; Riquelme, Ismael; Buchegger, Kurt; Mora-Lagos, Bárbara; Guzmán, Pablo; García Cañete, Patricia; Roa Strauch, Juan Carlos Enrique; Gloria Ili, Carmen; Brebi, PriscillaThe Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile.
- ItemExpression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients(2015) Suzuki, Hideo; Roa Strauch, Juan Carlos Enrique; Kawamoto, Toru; Ishige, Kazunori; Wistuba Oyarzún, Ignacio; Li, Donghui; Thomas, Melanie B.; Shoda, Junichi
- ItemFrequency of Human papillomavirus in women attending cervical cancer screening program in Chile(2017) Roa Strauch, Juan Carlos Enrique; Brebi, Priscilla.; Ili, Carmen G.; Andana, Alejandra.; Menzel, Doris.; Lopez, Jaime.; Guzman, Pablo.; Melo, Angelica.; Buchegger, Kurt.Abstract Background Human papillomavirus (HPV) is the etiological factor for cervical cancer and its precursor lesions. The characterization of HPV genotypes in preneoplastic lesions and cervical cancer could establishes the effectiveness of vaccination plan in Chilean population. The aim of this study was to determine HPV frequency in a group of women including in a cervical screening program in the public health care system in Chile. Methods We analyzed 985 cervical smears samples from women with different histological diagnosis, attending to public health care in Temuco-Chile between 2004 and 2012, to detect HPV genotypes, through PCR followed by reverse line blotting assay. Results HPV was found present in 80.8% (n = 796) of samples. Only a 5.6% of 985 samples were infected with a low-risk HPV, considering multiple infections. 10.5% (n = 8/76) of normal cervical epithelia, 83.5% (n = 208/249) and 87.6% (n = 557/636) of low and high grade squamous intraepithelial lesions, respectively, and 95.8% (n = 23/24) of squamous cervical carcinomas tested positive for HPV. HPV 16 was the most frequent genotype found (Overall 44.9%, n = 442/985; SCC: 62.5%, n = 15/24). A high variability of HPV types was also found in preneoplastic lesions, whereas there was a selection of genotypes in neoplasia. Also, there was a higher risk of infection with HPV 16 in women ≤26 years and 34–41 years old (p < 0.05), meanwhile infections with HPV 16 or HPV 18 have related with cancer development (p < 0.01). Conclusions These data provide further information about the frequency of HPV genotypes in women with cervical lesions in Chile, and the introduction of new targeted vaccines against a wider spectrum of HPV is suggested.Abstract Background Human papillomavirus (HPV) is the etiological factor for cervical cancer and its precursor lesions. The characterization of HPV genotypes in preneoplastic lesions and cervical cancer could establishes the effectiveness of vaccination plan in Chilean population. The aim of this study was to determine HPV frequency in a group of women including in a cervical screening program in the public health care system in Chile. Methods We analyzed 985 cervical smears samples from women with different histological diagnosis, attending to public health care in Temuco-Chile between 2004 and 2012, to detect HPV genotypes, through PCR followed by reverse line blotting assay. Results HPV was found present in 80.8% (n = 796) of samples. Only a 5.6% of 985 samples were infected with a low-risk HPV, considering multiple infections. 10.5% (n = 8/76) of normal cervical epithelia, 83.5% (n = 208/249) and 87.6% (n = 557/636) of low and high grade squamous intraepithelial lesions, respectively, and 95.8% (n = 23/24) of squamous cervical carcinomas tested positive for HPV. HPV 16 was the most frequent genotype found (Overall 44.9%, n = 442/985; SCC: 62.5%, n = 15/24). A high variability of HPV types was also found in preneoplastic lesions, whereas there was a selection of genotypes in neoplasia. Also, there was a higher risk of infection with HPV 16 in women ≤26 years and 34–41 years old (p < 0.05), meanwhile infections with HPV 16 or HPV 18 have related with cancer development (p < 0.01). Conclusions These data provide further information about the frequency of HPV genotypes in women with cervical lesions in Chile, and the introduction of new targeted vaccines against a wider spectrum of HPV is suggested.
- ItemGallbladder Cancer : expert consensus statement(2015) Aloia, Thomas A.; Jarufe Cassis, Nicolás; Javle, Milind; Maithel, Shishir K.; Roa Strauch, Juan Carlos Enrique; Adsay, Volkan; Coimbra, Felipe J. F.; Jarnagin, William R.
- ItemGallbladder polyps : Correlation of size and clinicopathologic characteristics based on updated definitions(2020) Taskin, O. C.; Basturk, O.; Reid, M. D.; Dursun, N.; Bagci, P.; Saka, B.; Balci, S.; Memis, B.; Roa Strauch, Juan Carlos Enrique; Bellolio, E.; Araya, J. C.; Tapia, O.; Losada, H.; Sarmiento, J.; Jang, K. T.; Jang, J. Y.; Pehlivanoglu, B.; Erkan, M.; Adsay, V.
- ItemGenome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506- binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population(2014) Brebi, P.; Maldonado, L.; Noordhuis, M.; Ili, C.; Leal, P.; Garcia, P.; Brait, M.; Ribas, J.; Michailidi, C.; Roa Strauch, Juan Carlos Enrique
- ItemGenotipificación del virus papiloma humano en mujeres bajo 25 años de edad participantes del Programa Nacional del Cáncer Cérvico-uterino en la Región de la Araucanía, Chile(2014) Melo, A.; Vasquez, A.; Andana, A.; Matamala, M.; Pino, T.; Guzman, P.; Hoffstetter, R.; Ili, C.; Brebi, P.; Roa Strauch, Juan Carlos Enrique
- «
- 1 (current)
- 2
- 3
- »