Browsing by Author "Rice, Andrew S. C."

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy
    (2013) Huanga, Wenlong; Calvo Bascuñan, Margarita; Karu, Kersti; Olausen, Hans R.; Bathgate, Gabriella; Okuse, Kenji; Bennett, David L. H.; Rice, Andrew S. C.
  • Thumbnail Image
    Item
    Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies
    (2025) Villa, Sara; Aasvang, Eske K.; Attal, Nadine; Baron, Ralf; Bourinet, Emmanuel; Calvo Bascuñán, Margarita; Finnerup, Nanna B.; Galosi, Eleonora; Hockley, James R. F.; Karlsson, Pall; Kemp, Harriet; Koerner, Jannis; Kutafina, Ekaterina; Lampert, Angelika; Murk, Margarita; Nochi, Zahra; Price, Theodore J.; Rice, Andrew S. C.; Sommer, Claudia; Taba, Pille
    Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.
  • Thumbnail Image
    Item
    Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis.
    (2025) Soliman, Nadia; Moisset, Xavier; Ferraro, Michael C.; Ciampi de Andrade, Daniel; Baron, Ralf; Belton, Joletta; Bennett, David L. H.; Calvo, Margarita; Dougherty, Patrick; Gilron, Ian; Hietaharju, Aki J.; Hosomi, Koichi; Kamerman, Peter R.; Kemp, Harriet; Enax-Krumova, Elena K.; McNicol, Ewan; Price, Theodore J.; Raja, Srinivasa N.; Rice, Andrew S. C.; Smith, Blair H.; Talkington, Fiona; Truini, Andrea; Vollert, Jan; Attal, Nadine; Finnerup, Nanna B.; Haroutounian, Simon; NeuPSIG Review Update Study Group
    There remains a substantial unmet need for effective and safe treatments for neuropathic pain. The Neuropathic Pain Special Interest Group aimed to update treatment recommendations, published in 2015, on the basis of new evidence from randomised controlled trials, emerging neuromodulation techniques, and advances in evidence synthesis.