Browsing by Author "Reyes, Montserrat"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer
    (2021) Goni, Francisca J.; Pena-Oyarzun, Daniel; Torres, Vicente A.; Reyes, Montserrat
    Background: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, which, according to histopathological criteria, are referred to as oral dysplasia and their diagnosis are associated with higher rates of malignant transformation towards cancer. We recently reported that aberrant activation of the Wnt/beta catenin pathway is due to overexpression of Wnt ligands in oral dysplasia. However, the expression of other regulators of this pathway, namely components of the beta-catenin destruction complex has not been explored in oral dysplasia.
  • No Thumbnail Available
    Item
    Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis
    (2024) Pena-Oyarzun, Daniel; Flores, Tania; Torres, Vicente A.; Quest, Andrew F. G.; Lobos-Gonzalez, Lorena; Kretschmar, Catalina; Contreras, Pamela; Maturana-Ramirez, Andrea; Criollo, Alfredo; Reyes, Montserrat
    Purpose: Oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, referred to as oral dysplasia. We recently reported that oral dysplasia is associated with aberrant activation of the Wnt/beta-catenin pathway, due to overexpression of Wnt ligands in a Porcupine (PORCN)-dependent manner. Pharmacologic inhibition of PORCN precludes Wnt secretion and has been proposed as a potential therapeutic approach to treat established cancers. Nevertheless, there are no studies that explore the effects of PORCN inhibition at the different stages of oral carcinogenesis.