Browsing by Author "Raggio, Marcela"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Diabetic Ketoacidosis in Type 1 Diabetes Onset in Latin American Children
    (2024) Hirschler, Valeria; Gonzalez, Claudio D.; Krochik, Gabriela; Rousos, Adriana M.; Andres, Maria E.; Riera, Francisca; Ibarcena, Paola Pinto; Molinari, Claudia; Porta, Luis F. Palacios; Prieto, Mariana; Mateu, Carolina Martinez; Barcala, Consuelo; Arrigo, Maria A.; Tachetti, Jacqueline.; Raggio, Marcela; Vacarezza, Veronica; Major, Maria L.; Sobrero, Angela Figueroa; Bogado, Ernesto; Lopez, Stella; Povedano, Paula Paz; Scaiola, Edit; Leiva, Fabiana; Pacheco, Gabriela; Pasayo, Patricia; Dupuy, Mariana; Torossi, Maria B.; Benitez, Amanda J.; Marassi, Andrea Escalante; Caballero, Zulema; Garcia, Ana L.; Mazzetti, Sandra; Pugliese, Maria I. Ruiz; Gonzalez, Diana S.; Grabois, Florencia; Villar, Carlos M. Del Aguila; Flores, Adriana B.
    Objective: To describe the patterns of diabetic ketoacidosis (DKA) occurrence in children newly diagnosed with type 1 diabetes (T1DM) across several Latin American pediatric diabetes centers from 2018 to 2022. Methods: A retrospective chart review included children under 18 with new -onset T1DM from 30 Latin American pediatric diabetes centers (Argentina, Chile, and Peru) between 30 December 2018 and 30 December 2022. Multiple logistic regression models examined the relationships between age, gender, medical insurance, BMI, and DKA at new -onset T1DM. As far as we know, there are no large studies in Latin American countries exploring the patterns of DKA in new -onset T1DM. Results: A total of 2,026 (983 females) children, median age 9.12 (5.8 -11.7) years with new-onset-T1DM were included. Approximately 50% had no medical insurance . Mean glucose values were 467 mg/dL, pH 7.21, bicarbonate 13 mEq/L, HbA1c 11.3%, and BMI 18. The frequency of DKA was 1,229 (60.7%), out of which only 447 (36%) were severe. There was a signi fi cant decrease in the frequency of DKA as age increased : 373 (70.2%) in children under 6, 639 (61.6%) in those between 6 and 12, 217 and (47.5%) in those over 12. Children with medical insurance (58.8%) had a signi fi - cantly lower frequency of DKA than those without (62.7%). The multiple logistic regression models showed that DKA was signi fi - cantly and inversely associated with age [OR, 0.72 (95% CI 0.60 - 0.86)], BMI [OR, 0.95 (95% CI 0.92 - 0.99)], and medical insurance [OR, 0.75 (95% CI 0.60 - 0.94)] adjusted for sex. Conclusion: Latin American children with new -onset T1DM exhibited a substantial occurrence of DKA. Younger ages and the lack of medical insurance were signi fi cantly associated with DKA in new -onset T1DM. J Pediatr Health Care. (2024) 38 , 544 - 551
  • No Thumbnail Available
    Item
    Real-world performance of the MiniMed 780G advanced hybrid closed loop system in Latin America: Substantial improvement in glycaemic control with each technology iteration of the MiniMed automated insulin delivery system
    (2023) Grassi, Bruno; Gomez, Ana Maria; Calliari, Luis Eduardo; Franco, Denise; Raggio, Marcela; Riera, Francisca; Castro, Matias; McVean, Jennifer; van den Heuvel, Tim; Arrieta, Arcelia; Castaneda, Javier; Cohen, Ohad
    Aim: We studied real-world performance of MiniMed (MM) 780G system users from Argentina, Brazil, Colombia and Chile (geographical analysis), and the effect of each technology iteration of the MM system on glycaemic control (technology iteration analysis).Materials and Methods: CareLink data from August 2020 to September 2022 were extracted. Endpoints included continuous glucose monitoring metrics. For the geographical analysis, aggregated endpoints for MM780G system users were calculated. For the technology iteration analysis, MM780G system user outcomes were compared with outcomes when the same individuals were still using the MM640G or MM670G system.Results: On average, 1025 MM780G system users from the geographical analysis were followed for 136 (SD 135) days, spent 91.5 (14.3)% in advanced hybrid closed loop, showed a glucose management indicator (GMI) of 6.7 (0.3)%, a time in range between 70 and 180 mg/dl (TIR) of 76.5 (9.0)%, and a time below range 70 mg/dl (TBR) of 2.7 (2.1)%. The percentage of users reaching targets of GMI < 7%, TIR > 70% and TBR < 4% was 80.8%, 78.1% and 80.1%, respectively. The technology iteration analysis on users transitioning from MM640G to MM780G system (N = 381) showed 0.4% decrease in GMI (7.1% to 6.7%, p < .0001), 10.7% increase in TIR (65.9% to 76.6%, p < .0001), while TBR remained. The percentage of insulin delivered automatically increased as well (47.5%-57.7%, p < .0001). Users transitioning from MM670G system (N = 78) showed a similar but less pronounced pattern.Conclusions: Real-world Latin American MM780G users on average showed good glucose control, achieving international targets. Glycaemic control increased with every technology iteration of the MM system, providing more automation each time.