Browsing by Author "Radua, Joaquim"

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    Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
    (2024) Georgiadis, Foivos; Lariviere, Sara; Glahn, David; Hong, L. Elliot; Kochunov, Peter; Mowry, Bryan; Loughland, Carmel; Pantelis, Christos; Henskens, Frans A.; Green, Melissa J.; Cairns, Murray J.; Michie, Patricia T.; Rasser, Paul E.; Catts, Stanley; Tooney, Paul; Scott, Rodney J.; Schall, Ulrich; Carr, Vaughan; Quide, Yann; Krug, Axel; Stein, Frederike; Nenadic, Igor; Brosch, Katharina; Kircher, Tilo; Gur, Raquel; Gur, Ruben; Satterthwaite, Theodore D.; Karuk, Andriana; Pomarol-Clotet, Edith; Radua, Joaquim; Fuentes-Claramonte, Paola; Salvador, Raymond; Spalletta, Gianfranco; Voineskos, Aristotle; Sim, Kang; Crespo-Facorro, Benedicto; Gutierrez, Diana Tordesillas; Ehrlich, Stefan; Crossley, Nicolas; Grotegerd, Dominik; Repple, Jonathan; Lencer, Rebekka; Dannlowski, Udo; Calhoun, Vince; Rootes-Murdy, Kelly; Demro, Caroline; Ramsay, Ian S.; Sponheim, Scott R.; Schmidt, Andre; Borgwardt, Stefan; Tomyshev, Alexander; Lebedeva, Irina; Hoeschl, Cyril; Spaniel, Filip; Preda, Adrian; Nguyen, Dana; Uhlmann, Anne; Stein, Dan J.; Howells, Fleur; Temmingh, Henk S.; Zuluaga, Ana M. Diaz; Jaramillo, Carlos Lopez; Iasevoli, Felice; Ji, Ellen; Homan, Stephanie; Omlor, Wolfgang; Homan, Philipp; Kaiser, Stefan; Seifritz, Erich; Misic, Bratislav; Valk, Sofie L.; Thompson, Paul; van Erp, Theo G. M.; Turner, Jessica A.; Bernhardt, Boris; Kirschner, Matthias
    Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations. To assess generalizability and specificity, we contextualized the influence of site, disease stages, and individual clinical factors and compared network associations of schizophrenia with that found in affective disorders. Our findings show schizophrenia-related cortical thinning is spatially associated with functional and structural hubs, suggesting that highly interconnected regions are more vulnerable to morphological alterations. Predominantly temporo-paralimbic and frontal regions emerged as epicenters with connectivity profiles linked to schizophrenia's alteration patterns. Findings were robust across sites, disease stages, and related to individual symptoms. Moreover, transdiagnostic comparisons revealed overlapping epicenters in schizophrenia and bipolar, but not major depressive disorder, suggestive of a pathophysiological continuity within the schizophrenia-bipolar-spectrum. In sum, cortical alterations over the course of schizophrenia robustly follow brain network architecture, emphasizing marked hub susceptibility and temporo-frontal epicenters at both the level of the group and the individual. Subtle variations of epicenters across disease stages suggest interacting pathological processes, while associations with patient-specific symptoms support additional inter-individual variability of hub vulnerability and epicenters in schizophrenia. Our work outlines potential pathways to better understand macroscale structural alterations, and inter- individual variability in schizophrenia.
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    Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times-Children and Adolescents (COH-FIT-C&A)
    (2022) Solmi, Marco; Estrade, Andres; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Do Cuenod, Kim Q.; von Kanel, Roland; Arrondo, Gonzalo; Fusar Poli, Paolo; Gorwood, Philip; Llorca, Pierre Michel; Krebs, Marie Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabbani, Golam; Skonieczna Zydecka, Karolina; Brambilla, Paolo; Favaro, Angela; Takamiya, Akihiro; Zoccante, Leonardo; Colizzi, Marco; Bourgin, Julie; Kaminski, Karol; Moghadasin, Maryam; Seedat, Soraya; Matthews, Evan; Wells, John; Vassilopoulou, Emilia; Gadelha, Ary; Su, Kuan Pin; Kwon, Jun Soo; Kim, Minah; Lee, Tae Young; Papsuev, Oleg; Mankova, Denisa; Boscutti, Andrea; Gerunda, Cristiano; Saccon, Diego; Righi, Elena; Monaco, Francesco; Croatto, Giovanni; Cereda, Guido; Demurtas, Jacopo; Brondino, Natascia; Veronese, Nicola; Enrico, Paolo; Politi, Pierluigi; Ciappolino, Valentina; Pfennig, Andrea; Bechdolf, Andreas; Meyer Lindenberg, Andreas; Kahl, Kai G.; Domschke, Katharina; Bauer, Michael; Koutsouleris, Nikolaos; Winter, Sibylle; Borgwardt, Stefan; Bitter, Istvan; Balazs, Judit; Czobor, Pal; Unoka, Zsolt; Mavridis, Dimitris; Tsamakis, Konstantinos; Bozikas, Vasilios P.; Tunvirachaisakul, Chavit; Maes, Michael; Rungnirundorn, Teerayuth; Supasitthumrong, Thitiporn; Haque, Ariful; Brunoni, Andre R.; Costardi, Carlos Gustavo; Schuch, Felipe Barreto; Polanczyk, Guilherme; Luiz, Jhoanne Merlyn; Fonseca, Lais; Aparicio, Luana, V; Valvassori, Samira S.; Nordentoft, Merete; Vendsborg, Per; Hoffmann, Sofie Have; Sehli, Jihed; Sartorius, Norman; Heuss, Sabina; Guinart, Daniel; Hamilton, Jane; Kane, John; Rubio, Jose; Sand, Michael; Koyanagi, Ai; Solanes, Aleix; Andreu Bernabeu, Alvaro; Caceres, Antonia San Jose; Arango, Celso; Diaz Caneja, Covadonga M.; Hidalgo Mazzei, Diego; Vieta, Eduard; Gonzalez Penas, Javier; Fortea, Lydia; Parellada, Mara; Fullana, Miquel A.; Verdolini, Norma; Farkova, Eva; Janku, Karolina; Millan, Mark; Honciuc, Mihaela; Moniuszko Malinowska, Anna; Loniewski, Igor; Samochowiec, Jerzy; Kiszkiel, Lukasz; Marlicz, Maria; Sowa, Pawel; Marlicz, Wojciech; Spies, Georgina; Stubbs, Brendon; Firth, Joseph; Sullivan, Sarah; Darcin, Asli Enez; Aksu, Hatice; Dilbaz, Nesrin; Noyan, Onur; Kitazawa, Momoko; Kurokawa, Shunya; Tazawa, Yuki; Anselmi, Alejandro; Cracco, Cecilia; Machado, Ana Ines; Estrade, Natalia; De Leo, Diego; Curtis, Jackie; Berk, Michael; Ward, Philip; Teasdale, Scott; Rosenbaum, Simon; Marx, Wolfgang; Horodnic, Adrian Vasile; Oprea, Liviu; Alexinschi, Ovidiu; Ifteni, Petru; Turliuc, Serban; Ciuhodaru, Tudor; Bolos, Alexandra; Matei, Valentin; Nieman, Dorien H.; Sommer, Iris; van Os, Jim; van Amelsvoort, Therese; Sun, Ching Fang; Guu, Ta Wei; Jiao, Can; Zhang, Jieting; Fan, Jialin; Zou, Liye; Yu, Xin; Chi, Xinli; de Timary, Philippe; van Winke, Ruud; Ng, Bernardo; Pena, Edilberto; Arellano, Ramon; Roman, Raquel; Sanchez, Thelma; Movina, Larisa; Morgado, Pedro; Brissos, Sofia; Aizberg, Oleg; Mosina, Anna; Krinitski, Damir; Mugisha, James; Sadeghi Bahmani, Dena; Sadeghi, Masoud; Hadi, Samira; Brand, Serge; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic, Dragana Ignjatovic; Lopez Jaramillo, Carlos; Efthymiou, Dimitris; Kuttichira, Praveenlal; Kallivayalil, Roy Abraham; Javed, Afzal; Afridi, Muhammad Iqbal; James, Bawo; Seb Akahomen, Omonefe Joy; Fiedorowicz, Jess; Carvalho, Andre F.; Daskalakis, Jeff; Yatham, Lakshmi N.; Yang, Lin; Okasha, Tarek; Dahdouh, Aicha; Gerdle, Bjorn; Tiihonen, Jari; Shin, Jae Il; Lee, Jinhee; Mhalla, Ahmed; Gaha, Lotfi; Brahim, Takoua; Altynbekov, Kuanysh; Negay, Nikolay; Nurmagambetova, Saltanat; Abu Jamei, Yasser; Weiser, Mark; Correll, Christoph U.
    Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www. coh-fit.com) is an on-line anonymous survey, available in 30 languages, involving >230 investigators from 49 countries supported by national/international professional associations. COH-FIT has thee waves (until the pandemic is declared over by the WHO, and 6-18 months plus 24-36 months after its end). In addition to adults, COH-FIT also includes adolescents (age 14-17 years), and children (age 6-13 years), recruited via nonprobability/snowball and representative sampling and assessed via self-rating and parental rating. Nonmodifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to promote health and prevent mental and physical illness in children and adolescents will be generated by COH-FIT. Co primary outcomes are changes in well-being (WHO-5) and a composite psychopathology P-Score. Multiple behavioral, family, coping strategy and service utilization factors are also assessed, including functioning and quality of life. Results: Up to June 2021, over 13,000 children and adolescents from 59 countries have participated in the COHFIT project, with representative samples from eleven countries. Limitations: Cross-sectional and anonymous design. Conclusions: Evidence generated by COH-FIT will provide an international estimate of the COVID-19 effect on children's, adolescents' and families', mental and physical health, well-being, functioning and quality of life, informing the formulation of present and future evidence-based interventions and policies to minimize adverse effects of the present and future pandemics on youth.
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    The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic
    (2022) Solmi, Marco; Estrade, Andrés; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Do Cuenod, Kim Q.; von Kanel, Roland; Arrondo, Gonzalo; Fusar Poli, Paolo; Gorwood, Philip; Llorca, Pierre Michel; Krebs, Marie Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabbani, Golam; Skonieczna Zydecka, Karolina; Brambilla, Paolo; Favaro, Angela; Takamiya, Akihiro; Zoccante, Leonardo; Colizzi, Marco; Bourgin, Julie; Kaminski, Karol; Moghadasin, Maryam; Seedat, Soraya; Matthews, Evan; Wells, John; Vassilopoulou, Emilia; Gadelha, Ary; Su, Kuan Pin; Kwon, Jun Soo; Kim, Minah; Lee, Tae Young; Papsuev, Oleg; Mankova, Denisa; Boscutti, Andrea; Gerunda, Cristiano; Saccon, Diego; Righi, Elena; Monaco, Francesco; Croatto, Giovanni; Cereda, Guido; Demurtas, Jacopo; Brondino, Natascia; Veronese, Nicola; Enrico, Paolo; Politi, Pierluigi; Ciappolino, Valentina; Pfennig, Andrea; Bechdolf, Andreas; Meyer Lindenberg, Andreas; Kahl, Kai G.; Domschke, Katharina; Bauer, Michael; Koutsouleris, Nikolaos; Winter, Sibylle; Borgwardt, Stefan; Bitter, Istvan; Balazs, Judit; Czobor, Pal; Unoka, Zsolt; Mavridis, Dimitris; Tsamakis, Konstantinos; Bozikas, Vasilios P.; Tunvirachaisakul, Chavit; Maes, Michael; Rungnirundorn, Teerayuth; Supasitthumrong, Thitiporn; Haque, Ariful; Brunoni, Andre R.; Costardi, Carlos Gustavo; Schuch, Felipe Barreto; Polanczyk, Guilherme; Luiz, Jhoanne Merlyn; Fonseca, Lais; Aparicio, Luana, V; Valvassori, Samira S.; Nordentoft, Merete; Vendsborg, Per; Hoffmann, Sofie Have; Sehli, Jihed; Sartorius, Norman; Heuss, Sabina; Guinart, Daniel; Hamilton, Jane; Kane, John; Rubio, Jose; Sand, Michael; Koyanagi, Ai; Solanes, Aleix; Andreu Bernabeu, Alvaro; San Jose Caceres, Antonia; Arango, Celso; Diaz Caneja, Covadonga M.; Hidalgo Mazzei, Diego; Vieta, Eduard; Gonzalez Penas, Javier; Fortea, Lydia; Parellada, Mara; Fullana, Miquel A.; Verdolini, Norma; Farkova, Eva; Janku, Karolina; Millan, Mark; Honciuc, Mihaela; Moniuszko Malinowska, Anna; Loniewski, Igor; Samochowiec, Jerzy; Kiszkiel, Lukasz; Marlicz, Maria; Sowa, Pawel; Marlicz, Wojciech; Spies, Georgina; Stubbs, Brendon; Firth, Joseph; Sullivan, Sarah; Darcin, Asli Enez; Aksu, Hatice; Dilbaz, Nesrin; Noyan, Onur; Kitazawa, Momoko; Kurokawa, Shunya; Tazawa, Yuki; Anselmi, Alejandro; Cracco, Cecilia; Ines Machado, Ana; Estrade, Natalia; De Leo, Diego; Curtis, Jackie; Berk, Michael; Ward, Philip; Teasdale, Scott; Rosenbaum, Simon; Marx, Wolfgang; Horodnic, Adrian Vasile; Oprea, Liviu; Alexinschi, Ovidiu; Ifteni, Petru; Turliuc, Serban; Ciuhodaru, Tudor; Bolos, Alexandra; Matei, Valentin; Nieman, Dorien H.; Sommer, Iris; van Os, Jim; van Amelsvoort, Therese; Sun, Ching Fang; Guu, Ta wei; Jiao, Can; Zhang, Jieting; Fan, Jialin; Zou, Liye; Yu, Xin; Chi, Xinli; de Timary, Philippe; van Winke, Ruud; Ng, Bernardo; Pena, Edilberto; Arellano, Ramon; Roman, Raquel; Sanchez, Thelma; Movina, Larisa; Morgado, Pedro; Brissos, Sofia; Aizberg, Oleg; Mosina, Anna; Krinitski, Damir; Mugisha, James; Sadeghi Bahmani, Dena; Sadeghi, Masoud; Hadi, Samira; Brand, Serge; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic, Dragana Ignjatovic; Lopez Jaramillo, Carlos; Efthymiou, Dimitris; Kuttichira, Praveenlal; Kallivayalil, Roy Abraham; Javed, Afzal; Afridi, Muhammad Iqbal; James, Bawo; Seb Akahomen, Omonefe Joy; Fiedorowicz, Jess; Carvalho, Andre F.; Daskalakis, Jeff; Yatham, Lakshmi N.; Yang, Lin; Okasha, Tarek; Dahdouh, Aicha; Gerdle, Bjorn; Tiihonen, Jari; Shin, Jae Il; Lee, Jinhee; Mhalla, Ahmed; Gaha, Lotfi; Brahim, Takoua; Altynbekov, Kuanysh; Negay, Nikolay; Nurmagambetova, Saltanat; Abu Jamei, Yasser; Weiser, Mark; Correll, Christoph U.
    Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.