Browsing by Author "Quintanilla Gómez, Rodrigo Arthur"
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- ItemAlcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication(2017) Tapia, C.; Mira, R.; Torres, A.; Jara, C.; Pérez, M.; Vergara, E.; Cerpa Nebott, Waldo Francisco; Quintanilla Gómez, Rodrigo Arthur
- ItemAmyloid-B-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide. Implications for the pathogenesis of Alzheimer's disease(2010) Dinamarca Ceballos, Margarita Constanza.; Sagal, Juan P.; Quintanilla Gómez, Rodrigo Arthur; Godoy, Juan A.; Arrázola, Macarena S; Inestrosa Cantín, NibaldoAbstract The presence of amyloid-β (Aβ) deposits in selected brain regions is a hallmark of Alzheimer's disease (AD). The amyloid deposits have "chaperone molecules" which play critical roles in amyloid formation and toxicity. We report here that treatment of rat hippocampal neurons with Aβ-acetylcholinesterase (Aβ-AChE) complexes induced neurite network dystrophia and apoptosis. Moreover, the Aβ-AChE complexes induced a sustained increase in intracellular Ca2+ as well as a loss of mitochondrial membrane potential. The Aβ-AChE oligomers complex also induced higher alteration of Ca2+ homeostasis compared with Aβ-AChE fibrillar complexes. These alterations in calcium homeostasis were reversed when the neurons were treated previously with lithium, a GSK-3β inhibitor; Wnt-7a ligand, an activator for Wnt Pathway; and an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801), demonstrating protective roles for activation of the Wnt signaling pathway as well as for NMDA-receptor inhibition. Our results indicate that the Aβ-AChE complexes enhance Aβ-dependent deregulation of intracellular Ca2+ as well as mitochondrial dysfunction in hippocampal neurons, triggering an enhanced damage than Aβ alone. From a therapeutic point of view, activation of the Wnt signaling pathway, as well as NMDAR inhibition may be important factors to protect neurons under Aβ-AChE attack.
- ItemConnexin 43 hemichannels and pannexin-1 channels contribute to the alpha-synuclein-induced dysfunction and death of astrocytes(2019) Díaz Jara, Esteban Fernando; Labra Ramírez, Valeria Cristina; Alvear, Tanhia F.; Mellado, Luis A.; Inostroza, Carla A.; Oyarzún Isamitt, Juan Esteban; Salgado Cortés, Nicole Andrea; Quintanilla Gómez, Rodrigo Arthur; Orellana Roca, Juan Andrés
- ItemNeuron-Glia crosstalk in the autonomic nervous system and Its possible role in the progression of metabolic syndrome: a new hypothesis.(2015) Del Río, R.; Quintanilla Gómez, Rodrigo Arthur; Orellana Roca, Juan Andrés; Retamal, M. A.
- ItemNew Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis(2017) Orellana Roca, Juan Andrés; Cerpa Nebott, Waldo Francisco; Carvajal, M; Lerma, J; Karahanian, E; Osorio, C; Quintanilla Gómez, Rodrigo Arthur
- ItemPhosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons(2014) Quintanilla Gómez, Rodrigo Arthur; Bernhardi Montgomery, Rommy von; Godoy Zeballos, Juan Alejandro; Inestrosa Cantín, Nibaldo
- ItemRole of PPAR gamma in the Differentiation and Function of Neurons(2014) Quintanilla Gómez, Rodrigo Arthur; Utreras, E.; Cabezas Opazo, F.
- ItemRosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells - Possible role of peroxisome proliferator-activated receptor-gamma (PPAR gamma) in the pathogenesis of Huntington disease(2008) Quintanilla Gómez, Rodrigo Arthur; Fuenzalida Morales, Karen Andrea; Bronfman A., Miguel L.
- ItemStimulation of Melanocortin Receptor-4 (MC4R) Prevents Mitochondrial Damage Induced by Binge Ethanol Protocol in Adolescent Rat Hippocampus(2020) Torres Juacida, Angie Kim; Tapia Rojas, Cheril Cecilia|Cerpa Nebott, Waldo Francisco; Quintanilla Gómez, Rodrigo Arthur
- ItemThiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway(2013) Quintanilla Gómez, Rodrigo Arthur; Godoy Zeballos, Juan Alejandro; Alfaro, I.; Cabezas, D.; Bernhardi Montgomery, Rommy von; Bronfman A., Miguel L.; Inestrosa Cantín, Nibaldo
- ItemTrolox and 17 Beta-Estradiol Protect Against Amyloid Beta-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway(2005) Quintanilla Gómez, Rodrigo Arthur; Inestrosa Cantín, Nibaldo