Browsing by Author "Quiñones, Verónica"

Now showing 1 - 4 of 4
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    Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice
    (2011) Amigo Boker, Ludwig Peter; Quiñones, Verónica; Leiva Mendoza, Andrea Alejandra; Busso, Dolores; Zanlungo Matsuhiro, Silvana; Nervi, Flavio; Rigotti Rivera, Attilio
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    Disfuncionalidad antioxidante de las lipoproteínas de alta densidad (HDL) en pacientes diabéticos descompensados
    (2015) Awad, Fernanda; Contreras Duarte, Susana de las Mercedes; Molina, Patricia; Quiñones, Verónica; Serrano, V.; Abbott Cáceres, Eduardo Francisco; Maiz, Alberto; Busso, Dolores; Rigotti Rivera, Attilio
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    Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet
    (2000) Amigo Boker, Ludwig Peter; Quiñones, Verónica; Mardones, Pablo; Zanlungo Matsuhiro, Silvana; Miquel Poblete, Juan Francisco; Nervi Oddone, Flavio; Rigotti Rivera, Attilio Gianpietro
    Background & aimsBecause apolipoprotein E (apoE) is a key cholesterol transport molecule involved in the hepatic uptake of chylomicron cholesterol, it may play a critical role in controlling bile cholesterol elimination and cholesterol gallstone formation induced by dietary cholesterol. To test this hypothesis, we studied biliary lipid secretion and gallstone formation in apoE-deficient mice fed cholesterol-rich diets.MethodsBile lipid outputs and gallstone sequence events were analyzed in apoE-deficient mice fed a high-cholesterol diet or a lithogenic diet compared with control animals.ResultsA high-cholesterol diet increased biliary cholesterol secretion and gallbladder bile cholesterol concentration in wild-type mice; the increase in bile cholesterol secretion was significantly attenuated in apoE-deficient mice. ApoE knockout mice fed a high-cholesterol lithogenic diet had a markedly lower frequency of gallbladder bile cholesterol crystal and gallstone formation than wild-type mice, which was most likely a result of the decreased cholesterol saturation index found in gallbladder bile of apoE-deficient mice.ConclusionsThese results show that apoE expression is an important factor for regulating both biliary secretion of diet-derived cholesterol as well as diet-induced cholesterol gallstone formation in mice.
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    RNA editing of apocytochrome b (cob) transcripts in mitochondria from two genera of plants
    (1993) Zanlungo Matsuhiro, Silvana; Bégu, Dominique; Quiñones, Verónica; Araya, Alejandro; Jordana De Buen, Xavier
    Editing of the complete coding region of cob transcripts from two genera of plants has been studied by cDNA sequence analysis. Eighteen and nine C residues are edited into U in the mitochondrial transcripts from wheat and potato respectively. Both systems share eight common editing sites; ten codons edited in wheat are "pre-edited" at the genomic level in potato, and one codon edited in potato is "pre-edited" in wheat. Most amino-acid modifications lead to hydrophobic residues and increase the homology between the COB polypeptides and the corresponding protein of other species. In two out of the nine potato cDNA clones, an additional C-to-T modification, which also leads to a change in the encoded amino acid, was identified. Heterogeneity observed at the carboxy-terminus of the COB open reading frame in Triticum aestivum and Triticum timopheevi is not corrected by editing.