Browsing by Author "Pires, Yumay"

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    Endobronchial Involvement in Idiopathic Hypereosinophilic Syndrome
    (2015) Fernandez Bussy, Sebastian; Antunez, Miguel; Pires, Yumay; Labarca, Gonzalo
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    Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
    (2006) Castiblanco Galvis, Adriana; Pires, Yumay; Wistuba Oyarzún, Ignacio; Riquelme Sánchez, Erick Marcelo; Andrade M., Leonardo; Corvalán R., Alejandro
    Background: Endomeotrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis. Somatic mutations of PTEN (10q23.3) are present in endothelial endometrioid carcinoma. Therefore, these mutations could be also present in ovarian tumors Molecular studies show that solitary endometriotic cysts are monoclonal, have aneuploid DNA, have a loss of 9p, 11q and 22q heterozygosity (LOH) and a higher cellular proliferation index of the epithelial component. Aim: To determine the cellular proliferation index using Ki 67, the immunohistochemical expression of PTEN and LOH in patients with ovarian endometriosis without atypia (EN), ovarian endometriosis with atypia (P-A) and endometriosis with adjacent ovarian carcinoma (0). Material and methods: Paraffin embedded samples of 37 endometrioid and clear cell carcinomas of the ovary (CC/CE), 15 solitary ovarian EN and 15 ovarian EA, were studied. Expression of Ki 67 and PTEN was measured by immunohistochemistry. LOH of 10q23-3 locus was measured by polymerase chain reaction. Results: Ki 67 was 5.5 and 23% in EA and EN, respectively (p < 0.005). There was a histological correlation between LA and a higher cellular proliferation index. PTEN was negative in 5 of 15 EN, 9 of 15 EA and 30 of 37 CE/CC. There was a correlation between LOH and loss of PTEN protein in EN, EA and ET(60%), Conclusions: Negative expression on PTEN in EN; EA; ET and CE/CC is a manifestation of the inactivation of this gene. The mechanisms that cause this inactivation, must be elucidated.
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    Treatment failure in community-adquired pneumonia: coccidioidomycosis in a traveler patient
    (SOC CHILENA INFECTOLOGIA, 2013) Cabello, Hernan; Labarca, Gonzalo; Fernandez Bussy, Sebastian; Cabello, Francisca; Pires, Yumay; Soto, Rodrigo; Thompson, Luis
    Treatment failure in community-acquired pneumonia is defined as a clinical condition with inadequate response to antimicrobial therapy. Resistant and unusual microorganisms and noninfectious causes are responsible for treatment failure. Coccidioides immitis is a fungus that causes pneumonia in the northern hemisphere, especially in the United States and northern Mexico. We report a case of pulmonary coccidioidomycosis imported from Mexico to Chile. After a comprehensive study, histopathology was able to establish Coccidiodes immitis as the causative agent, achieving clinical and radiological improvement with antifungal therapy.