Browsing by Author "Pino, Jose"

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    MobileMap: A collaborative application to support emergency situations in urban areas
    (IEEE, 2009) Monares, Alvaro; Ochoa, Sergio; Pino, Jose; Herskovic, Valeria; Neyem, Hugo Andres
    One of the problems affecting fire departments in Latin America is the lack of a strong infrastructure to overcome their communication problems. Because these organizations are mainly volunteer and receive minimal support from government agencies, most existing solutions are not applicable for them. This article presents a low-cost mobile groupware application, which may be used in emergency situations to overcome the firefighters' communication problems. The tool, named MobileMap, allows exchanging textual and graphical information using mobile devices. Therefore, this solution complements the frequently over-used radio communication systems. This tool was evaluated in a simulated and a real scenario; the obtained results are highly encouraging.
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    Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity
    (2007) Celedon, Gloria; Gonzalez, Gustavo; Pino, Jose; Lissi, Eduardo A.
    We describe an altered membrane band 3 protein-mediated anion transport in erythrocytes exposed to peroxynitrite, and relate the loss of anion transport to cell damage and to band 3 oxidative modifications. We found that peroxynitrite down-regulate anion transport in a dose dependent relation (100-300 mu moles/1). Hemoglobin oxidation was found at all peroxynitrite concentrations studied. A dose-dependent band 3 protein crosslinking and tyrosine nitration were also observed. Band 3 protein modifications were concomitant with a decrease in transport activity. (-)-Epicatechin avoids band 3 protein nitration but barely affects its transport capacity, suggesting that both processes are unrelated. N-acetyl cysteine partially reverted the loss of band 3 transport capacity. It is concluded that peroxynitrite promotes a decrease in anion transport that is partially due to the reversible oxidation of band 3 cysteine residues. Additionally, band 3 tyrosine nitration seems not to be relevant for the loss of its anion transport capacity.