Browsing by Author "Pickett, Brett E."

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    Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection
    (2020) Kau, Drishti; Rathnasinghe, Raveen Shevantha; Ferrés, Marcela; Tan, Gene S.; Barrera Vásquez, Aldo Vincent; Pickett, Brett E.; Methe, Barbara A.; Das, Suman; Budnik Ojeda, Isolda Cecilia; Halpin, Rebecca A.; Wentworth, David; Schmolke, Mirco; Mena, Ignacio; Albrecht, Randy A.; Singh, Indresh; Nelson, Karen E.; Garcia Sastre, Adolfo; Dupont, Chris L.; Medina, Rafael
    Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are largely unknown. Here, we report a longitudinal study to assess the temporal dynamics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets. Uninfected human patients and ferret URT microbiomes have stable healthy ecostate communities both within and between individuals. In contrast, infected patients and ferrets exhibit large changes in bacterial community composition over time and between individuals. The unhealthy ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clearance and recovery. Pseudomonadales associate statistically with the disturbed microbiomes of infected individuals. The dynamic and resilient microbiome during influenza virus infection in multiple hosts provides a compelling rationale for the maintenance of the microbiome homeostasis as a potential therapeutic target to prevent IAV associated bacterial co-infections. Influenza A virus (IAV) infection can be exacerbated by bacterial co-infections but the effect of IAV on the upper respiratory tract (URT) microbiome remains unclear. Here, the authors compare the dynamics of the UTR microbiome in IAV-infected ferrets and humans, finding similar trends at the ecosystem and individual taxon level in both hosts.