Browsing by Author "Perret P., Cecilia"

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    Botulismo infantil: Comunicación de un caso y revisión del tema
    (2008) Córdova, Guilliana; Escobar Henríquez, Raul; Perret P., Cecilia; Castillo, Andrés; Carrasco O., Juan Andrés; Rodríguez C., José Ignacio
    Background: Infant botulism is a rare and potentially lethal neurological disease produced by the ingestion of a neurotoxin secreted by Clostridium botulinum, causing diffuse paralysis. Objective: Describe the first case in Chile since the establishment of an obligatory report and describe the diagnosis, clinical presentation and outcome. Case-report: A 2 months-old male with 48 hours of poor feeding and swallowing, weak cry, listlessness and constipation. He was admitted for hospitalization with probable sepsis and required tracheotomy due to apnea with failed endotracheal intubation, requiring mechanical ventilation for 150 days and hospitalization during 180 days. The diagnosis was confirmed by isolating Clostridium botulinum toxin from stool. Conclusion: The diagnosis of infant botulism requires a high suspicion index and the treatment includes intensive care monitorization with general support.
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    Evaluación de métodos diagnósticos para sífilis congénita
    (2000) Salazar J., Aurora; Perret P., Cecilia; Chávez P., Ana; Garcia C., Patricia; Millan O., Zunilda; Goycoolea M., Manuela; Parada B., Jacqueline; Urra M., Liliana; Ahumada H., Eugenia; Yoma B., M. Teresa; Duque O., Clara; Herman L., Odette; Quiroga G., Teresa
    Congenital syphilis is a relevant problem in our country. At the present, no routine method is available to verify the diagnostic. This multicenter prospective study recruited serum samples reactive for VDRL of sixty mothers with their respective infant (n = 120). In addition to the routinely used screening assay (RPR, VDRL) the following tests were performed: serological detection of specific antibodies to Treponema pallidum for IgM ( Pathozyme®, Captia® IgM), for IgG (Captia® IgG) and for IgG/IgM ( MHA-TP; Pathozyme competition®, ICE Syphilis®, Determine®). A good agreement was observed between the immunoassays for IgG alone or IgG/IgM (90%) and for IgM alone or IgG/IgM (87.5%). Every mother who had syphilis in the moment of the study or had had syphilis before, and her newborn child, were positive for IgG. Only 64% of the mothers with adequate treatment during their pregnancy had a positive titer for IgM and all of their newborn were not reactive for IgM. The mothers whose treatment was inadequate had IgM titers positive in 82.3% and their children had IgM positive in 11.8%. No correlation was found between a positive maternal IgM titer and the risk of the infant to present the disease. The newborn IgM titer is a useful parameter for an early diagnosis but a negative result cannot discard this pathology.