Browsing by Author "Perez-Padilla, Rogelio"

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    Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016
    (2017) Wang, Haidong; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbafati, Cristiana; Abbas, Kaja M.; Abd-Allah, Foad; Abera, Semaw Ferede; Abraha, Haftom Niguse; Abu-Raddad, Laith J.; Abu-Rmeileh, Niveen M. E.; Adedeji, Isaac Akinkunmi; Adedoyin, Rufus Adesoji; Adetifa, Ifedayo Morayo O.; Adetokunboh, Olatunji; Afshin, Ashkan; Aggarwal, Rakesh; Agrawal, Anurag; Agrawal, Sutapa; Kiadaliri, Aliasghar Ahmad; Ahmed, Muktar Beshir; Aichour, Amani Nidhal; Aichour, Ibthiel; Aichour, Miloud Taki Eddine; Aiyar, Sneha; Akanda, Shafqat; Akinyemiju, Tomi F.; Akseer, Nadia; Al-Eyadhy, Ayman; Al Lami, Faris Hasan; Alabed, Samer; Alahdab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Alam, Noore; Alasfoor, Deena; Aldridge, Robert William; Alene, Kefyalew Addis; Alhabib, Samia; Ali, Raghib; Alizadeh-Navaei, Reza; Aljunid, Syed M.; Alkaabi, Juma M.; Alkerwi, Ala'a; Alla, Francois; Allam, Shalini D.; Allebeck, Peter; Al-Raddadi, Rajaa; Alsharif, Ubai; Altirkawi, Khalid A.; Martin, Elena Alvarez; Alvis-Guzman, Nelson; Amare, Azmeraw T.; Ameh, Emmanuel A.; Amini, Erfan; Ammar, Walid; Amoako, Yaw Ampem; Anber, Nahla; Andrei, Catalina Liliana; Androudi, Sofia; Ansari, Hossein; Ansha, Mustafa Geleto; Antonio, Carl Abelardo T.; Anwari, Palwasha; Arnlov, Johan; Arora, Megha; Al Artaman; Aryal, Krishna Kumar; Asayesh, Hamid; Asgedom, Solomon Weldegebreal; Asghar, Rana Jawad; Assadi, Reza; Atey, Tesfay Mehari; Atre, Sachin R.; Avila-Burgos, Leticia; Avokpaho, Euripide Frinel G. Arthur; Awasthi, Ashish; Quintanilla, Beatriz Paulina Ayala; Babalola, Tesleem Kayode; Bacha, Umar; Badawi, Alaa; Balakrishnan, Kalpana; Balalla, Shivanthi; Barac, Aleksandra; Barber, Ryan M.; Barboza, Miguel A.; Barker-Collo, Suzanne L.; Barnighausen, Till; Barquera, Simon; Barregard, Lars; Barrero, Lope H.; Baune, Bernhard T.; Bazargan-Hejazi, Shahrzad; Bedi, Neeraj; Beghi, Ettore; Bejot, Yannick; Bekele, Bayu Begashaw; Bell, Michelle L.; Bello, Aminu K.; Bennett, Derrick A.; Bennett, James R.; Bensenor, Isabela M.; Benson, Jennifer; Berhane, Adugnaw; Berhe, Derbew Fikadu; Bernabe, Eduardo; Beuran, Mircea; Beyene, Addisu Shunu; Bhala, Neeraj; Bhansali, Anil; Bhaumik, Soumyadeep; Bhutta, Zulfiqar A.; Bikbov, Boris; Birungi, Charles; Biryukov, Stan; Bisanzio, Donal; Bizuayehu, Habtamu Mellie; Bjerregaard, Peter; Blosser, Christopher D.; Boneya, Dube Jara; Boufous, Soufiane; Bourne, Rupert R. A.; Brazinova, Alexandra; Breitborde, Nicholas J. K.; Brenner, Hermann; Brugha, Traolach S.; Bukhman, Gene; Negesa, Lemma; Bulto, Bulto; Bumgarner, Blair Randal; Burch, Michael; Butt, Zahid A.; Cahill, Leah E.; Cahuana-Hurtado, Lucero; Campos-Nonato, Ismael Ricardo; Car, Josip; Car, Mate; Crdenas, Rosario; Carpenter, David O.; Carrero, Juan Jesus; Carter, Austin; Castaneda-Orjuela, Carlos A.; Rivas, Jacqueline Castillo; Castro, Franz F.; Castro, Ruben Estanislao; Catala-Lopez, Ferran; Chen, Honglei; Chiang, Peggy Pei-Chia; Chibalabala, Mirriam; Chisumpa, Vesper Hichilombwe; Chitheer, Abdulaal A.; Choi, Jee-Young Jasmine; Christensen, Hanne; Christopher, Devasahayam Jesudas; Ciobanu, Liliana G.; Cirillo, Massimo; Cohen, Aaron J.; Colquhoun, Samantha M.; Coresh, Josef; Criqui, Michael H.; Cromwell, Elizabeth A.; Crump, John A.; Dandona, Lalit; Dandona, Rakhi; Dargan, Paul I.; das Neves, Jose; Davey, Gail; Davitoiu, Dragos V.; Davletov, Kairat; de Courten, Barbora; De Leo, Diego; Degenhardt, Louisa; Deiparine, Selina; Dellavalle, Robert P.; Deribe, Kebede; Deribew, Amare; Des Jarlais, Don C.; Dey, Subhojit; Dharmaratne, Samath D.; Dherani, Mukesh K.; Diaz-Torne, Cesar; Ding, Eric L.; Dixit, Priyanka; Djalalinia, Shirin; Huyen Phuc Do; Doku, David Teye; Donnelly, Christl Ann; Priscila, Kadine; dos Santos, Bender; Douwes-Schultz, Dirk; Driscoll, Tim R.; Duan, Leilei; Dubey, Manisha; Duncan, Bruce Bartholow; Dwivedi, Laxmi Kant; Ebrahimi, Hedyeh; El Bcheraoui, Charbel; Ellingsen, Christian Lycke; Enayati, Ahmadali; Endries, Aman Yesuf; Ermakov, Sergey Petrovich; Eshetie, Setegn; Eshrati, Babak; Eskandarieh, Sharareh; Esteghamati, Alireza; Estep, Kara; Fanuel, Belayneh Bekele Fanuel; Faro, Andre; Farvid, Maryam S.; Farzadfar, Farshad; Feigin, Valery L.; Fereshtehnejad, Seyed-Mohammad; Fernandes, Jefferson G.; Fernandes, Joao C.; Feyissa, Tesfaye Regassa; Filip, Irina; Fischer, Florian; Foigt, Nataliya; Foreman, Kyle J.; Frank, Tahvi; Franklin, Richard C.; Fraser, Maya; Friedman, Joseph; Frostad, Joseph J.; Fullman, Nancy; Furst, Thomas; Furtado, Joao M.; Futran, Neal D.; Gakidou, Emmanuela; Gambashidze, Ketevan; Gamkrelidze, Amiran; Gankpe, Fortune Gbetoho; Garcia-Basteiro, Alberto L.; Gebregergs, Gebremedhin Berhe; Gebrehiwot, Tsegaye Tewelde; Gebrekidan, Kahsu Gebrekirstos; Gebremichael, Mengistu Welday; Gelaye, Amha Admasie; Geleijnse, Johanna M.; Gemechu, Bikila Lencha; Gemechu, Kasiye Shiferaw; Genova-Maleras, Ricard; Gesesew, Hailay Abrha; Gething, Peter W.; Gibney, Katherine B.; Gill, Paramjit Singh; Gillum, Richard F.; Giref, Ababi Zergaw; Girma, Bedilu Weji; Giussani, Giorgia; Goenka, Shifalika; Gomez, Beatriz; Gona, Philimon N.; Gopalani, Sameer Vali; Goulart, Alessandra Carvalho; Graetz, Nicholas; Gugnani, Harish Chander; Gupta, Prakash C.; Gupta, Rahul; Gupta, Rajeev; Gupta, Tanush; Gupta, Vipin; Haagsma, Juanita A.; Hafezi-Nejad, Nima; Bidgoli, Hassan Haghparast; Hakuzimana, Alex; Halasa, Yara A.; Hamadeh, Randah Ribhi; Hambisa, Mitiku Teshome; Hamidi, Samer; Hammami, Mouhanad; Hancock, Jamie; Handal, Alexis J.; Hankey, Graeme J.; Hao, Yuantao; Harb, Hilda L.; Hareri, Habtamu Abera; Harikrishnan, Sivadasanpillai; Haro, Josep Maria; Hassanvand, Mohammad Sadegh; Havmoeller, Rasmus; Hay, Roderick J.; Hay, Simon I.; He, Fei; Heredia-Pi, Ileana Beatriz; Herteliu, Claudiu; Hilawe, Esayas Haregot; Hoek, Hans W.; Horita, Nobuyuki; Hosgood, H. Dean; Hostiuc, Sorin; Hotez, Peter J.; Hoy, Damian G.; Hsairi, Mohamed; Htet, Aung Soe; Hu, Guoqing; Huang, Hsiang; Huang, John J.; Iburg, Kim Moesgaard; Igumbor, Ehimario Uche; Ileanu, Bogdan Vasile; Inoue, Manami; Irenso, Asnake Ararsa; Irvine, Caleb M. S.; Islam, Nazrul; Jacobsen, Kathryn H.; Jaenisch, Thomas; Jahanmehr, Nader; Jakovljevic, Mihajlo B.; Javanbakht, Mehdi; Jayatilleke, Achala Upendra; Jeemon, Panniyammakal; Jensen, Paul N.; Jha, Vivekanand; Jin, Ye; John, Denny; John, Oommen; Johnson, Sarah Charlotte; Jonas, Jost B.; Jurisson, Mikk; Kabir, Zubair; Kadel, Rajendra; Kahsay, Amaha; Kalkonde, Yogeshwar; Kamal, Ritul; Kan, Haidong; Karch, Andre; Karema, Corine Kakizi; Karimi, Seyed M.; Karthikeyan, Ganesan; Kasaeian, Amir; Kassaw, Nigussie Assefa; Kassebaum, Nicholas J.; Kastor, Anshul; Katikireddi, Srinivasa Vittal; Kaul, Anil; Kawakami, Norito; Kazanjan, Konstantin; Keiyoro, Peter Njenga; Kelbore, Sefonias Getachew; Kemp, Andrew Haddon; Kengne, Andre Pascal; Keren, Andre; Kereselidze, Maia; Kesavachandran, Chandrasekharan Nair; Ketema, Ezra Belay; Khader, Yousef Saleh; Khalil, Ibrahim A.; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khang, Young-Ho; Khera, Sahil; Khoja, Abdullah Tawfih Abdullah; Khosravi, Mohammad Hossein; Kibret, Getiye Dejenu; Kieling, Christian; Kim, Cho-Il; Kim, Daniel; Kim, Pauline; Kim, Sungroul; Kim, Yun Jin; Kimokoti, Ruth W.; Kinfu, Yohannes; Kishawi, Sami; Kissimova-Skarbek, Katarzyna A.; Kissoon, Niranjan; Kivimaki, Mika; Knudsen, Ann Kristin; Kokubo, Yoshihiro; Kopec, Jacek A.; Kosen, Soewarta; Koul, Parvaiz A.; Koyanagi, Ai; Kravchenko, Michael; Krohn, Kristopher J.; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kuipers, Ernst J.; Kulikoff, Xie Rachel; Kulkarni, Veena S.; Kumar, G. Anil; Kumar, Pushpendra; Kumsa, Fekede Asefa; Kutz, Michael; Lachat, Carl; Lagat, Abraham K.; Lager, Anton Carl Jonas; Lal, Dharmesh Kumar; Lalloo, Ratilal; Lambert, Nkurunziza; Lan, Qing; Lansingh, Van C.; Larson, Heidi J.; Larsson, Anders; Laryea, Dennis Odai; Lavados, Pablo M.; Laxmaiah, Avula; Lee, Paul H.; Leigh, James; Leung, Janni; Leung, Ricky; Levi, Miriam; Li, Yongmei; Liao, Yu; Liben, Misgan Legesse; Lim, Stephen S.; Linn, Shai; Lipshultz, Steven E.; Liu, Shiwei; Lodha, Rakesh; Logroscino, Giancarlo; Lorch, Scott A.; Lorkowski, Stefan; Lotufo, Paulo A.; Lozano, Rafael; Lunevicius, Raimundas; Lyons, Ronan A.; Ma, Stefan; Macarayan, Erlyn Rachelle King; Machado, Isis Eloah; Mackay, Mark T.; Abd el Razek, Mohammed Magdy; Magis-Rodriguez, Carlos; Mahdavi, Mahdi; Majdan, Marek; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Malhotra, Rajesh; Malta, Deborah Carvalho; Mantovani, Lorenzo G.; Manyazewal, Tsegahun; Mapoma, Chabila C.; Marczak, Laurie B.; Marks, Guy B.; Martinez-Raga, Jose; Martins-Melo, Francisco Rogerlndio; Massano, Joao; Maulik, Pallab K.; Mayosi, Bongani M.; Mazidi, Mohsen; McAlinden, Colm; McGarvey, Stephen Theodore; McGrath, John J.; Mckee, Martin; Mehata, Suresh; Mehndiratta, Man Mohan; Mehta, Kala M.; Meier, Toni; Mekonnen, Tefera Chane; Meles, Kidanu Gebremariam; Memiah, Peter; Memish, Ziad A.; Mendoza, Walter; Mengesha, Melkamu Merid; Mengistie, Mubarek Abera; Tadese, Desalegn; Menon, Mengistu Geetha R.; Menota, Bereket Gebremichael; Mensah, George A.; Meretoja, Atte; Meretoja, Tuomo J.; Mezgebe, Haftay Berhane; Micha, Renata; Mikesell, Joseph; Miller, Ted R.; Mills, Edward J.; Minnig, Shawn; Mirarefin, Mojde; Mirrakhimov, Erkin M.; Misganaw, Awoke; Mishra, Shiva Raj; Mohammad, Karzan Abdulmuhsin; Mohammadi, Alireza; Mohammed, Kedir Endris Shafiu Mohammed; Mohan, Murali B. V.; Mohanty, Sanjay K.; Mokdad, Ali H.; Assaye, Ashagre Molla; Mollenkopf, Sarah K.; Molokhia, Mariam; Monasta, Lorenzo; Hernandez, Julio Cesar Montanez; Montico, Marcella; Mooney, Meghan D.; Moore, Ami R.; Moradi-Lakeh, Maziar; Moraga, Paula; Morawska, Lidia; Velasquez, Ilais Moreno; Mori, Rintaro; Morrison, Shane D.; Mruts, Kalayu Birhane; Mueller, Ulrich O.; Mullany, Erin; Muller, Kate; Venkata, Gudlavalleti; Murthy, Satyanarayana; Murthy, Srinivas; Musa, Kamarul Imran; Nachega, Jean B.; Nagata, Chie; Nagel, Gabriele; Naghavi, Mohsen; Naidoo, Kovin S.; Nanda, Lipika; Nangia, Vinay; Nascimento, Bruno Ramos; Natarajan, Gopalakrishnan; Negoi, Ionut; Cuong Tat Nguyen; Ningrum, Dina Nur Anggraini; Nisar, Muhammad Imran; Nomura, Marika; Vuong Minh Nong; Norheim, Ole F.; Norrving, Bo; Noubiap, Jean Jacques N.; Nyakarahuka, Luke; Obermeyer, Carla Makhlouf; O'Donnell, Martin J.; Ogbo, Felix Akpojene; Oh, In-Hwan; Okoro, Anselm; Oladimeji, Olanrewaju; Olagunju, Andrew Toyin; Olusanya, Bolajoko Olubukunola; Olusanya, Jacob Olusegun; Oren, Eyal; Ortiz, Alberto; Osgood-Zimmerman, Aaron; Ota, Erika; Owolabi, Mayowa O.; Oyekale, Abayomi Samuel; Pa, Mahesh; Pacella, Rosana E.; Pakhale, Smita; Pana, Adrian; Panda, Basant Kumar; Panda-Jonas, Songhomitra; Park, Eun-Kee; Parsaeian, Mahboubeh; Patel, Tejas; Patten, Scott B.; Patton, George C.; Paudel, Deepak; Pereira, David M.; Perez-Padilla, Rogelio; Perez-Ruiz, Fernando; Perico, Norberto; Pervaiz, Aslam; Pesudovs, Konrad; Peterson, Carrie Beth; Petri, William Arthur; Petzold, Max; Phillips, Michael Robert; Piel, Frederic B.; Pigott, David M.; Pishgar, Farhad; Plass, Dietrich; Polinder, Suzanne; Popova, Svetlana; Postma, Maarten J.; Poulton, Richie G.; Pourmalek, Farshad; Prasad, Narayan; Purwar, Manorama; Qorbani, Mostafa; Rabiee, Rynaz H. S.; Radfar, Amir; Rafay, Anwar; Rahimi-Movaghar, Afarin; Rahimi-Movaghar, Vafa; Rahman, Mahfuzar; Rahman, Mohammad Hifz Ur; Rahman, Sajjad Ur; Rai, Rajesh Kumar; Rajsic, Sasa; Ram, Usha; Rana, Saleem M.; Ranabhat, Chhabi Lal; Rao, Paturi Vishnupriya; Rawaf, Salman; Ray, Sarah E.; Rego, Maria Albertina Santiago; Rehm, Jugen; Reiner, Robert C.; Remuzzi, Giuseppe; Renzaho, Andre M. N. N.; Resnikoff, Serge; Rezaei, Satar; Rezai, Mohammad Sadegh; Ribeiro, Antonio L.; Rokni, Mohammad Bagher; Ronfani, Luca; Roshandel, Gholamreza; Roth, Gregory A.; Rothenbacher, Dietrich; Roy, Ambuj; Rubagotti, Enrico; Ruhago, George Mugambage; Saadat, Soheil; Sabde, Yogesh Damodar; Sachdev, Perminder S.; Sadat, Nafis; Safdarian, Mahdi; Safiri, Sare Safi Saeid; Sagar, Rajesh; Sahathevan, Ramesh; Sahebkar, Amirhossein; Sahraian, Mohammad Ali; Salama, Joseph; Salamati, Payman; Salomon, Joshua A.; Salvi, Sundeep Santosh; Samy, Abdallah M.; Sanabria, Juan Ramon; Sanchez-Nino, Maria Dolores; Santos, Itamar S.; Milicevic, Milena M. Santric; Sarmiento-Suarez, Rodrigo; Sartorius, Benn; Satpathy, Maheswar; Sawhney, Monika; Saxena, Sonia; Saylan, Mete I.; Schmidt, Maria Ines; Schneider, Ione J. C.; Schutte, Aletta E.; Schwebel, David C.; Schwendicke, Falk; Seedat, Soraya; Seid, Abdulbasit Musa; Sepanlou, Sadaf G.; Servan-Mori, Edson E.; Shackelford, Katya Anne; Shaheen, Amira; Shahraz, Saeid; Shaikh, Masood Ali; Shamsipour, Mansour; Shamsizadeh, Morteza; Islam, Sheikh Mohammed Shariful; Sharma, Jayendra; Sharma, Rajesh; She, Jun; Shen, Jiabin; Shetty, Balakrishna P.; Shi, Peilin; Shibuya, Kenji; Shigematsu, Mika; Shiri, Rahman; Shiue, Ivy; Shrime, Mark G.; Sigfusdottir, Inga Dora; Silberberg, Donald H.; Silpakit, Naris; Silva, Diego Augusto Santos; Silva, Joao Pedro; Silveira, Dayane Gabriele Alves; Sindi, Shireen; Singh, Abhishek; Singh, Jasvinder A.; Singh, Prashant Kumar; Singh, Virendra; Sinha, Dhirendra Narain; Skiadaresi, Eirini; Sligar, Amber; Smith, David L.; Sobaih, Badr H. A.; Sobngwi, Eugene; Soneji, Samir; Soriano, Joan B.; Sreeramareddy, Chandrashekhar T.; Srinivasan, Vinay; Stathopoulou, Vasiliki; Steel, Nicholas; Stein, Dan J.; Steiner, Caitlyn; Stockl, Heidi; Stokes, Mark Andrew; Strong, Mark; Sufiyan, Muawiyyah Babale; Suliankatchi, Rizwan Abdulkader; Sunguya, Bruno F.; Sur, Patrick J.; Swaminathan, Soumya; Sykes, Bryan L.; Szoeke, Cassandra E. I.; Tabares-Seisdedos, Rafael; Tadakamadla, Santosh Kumar; Tadese, Fentaw; Tandon, Nikhil; Tanne, David; Tarajia, Musharaf; Tavakkoli, Mohammad; Taveira, Nuno; Tehrani-Banihashemi, Arash; Tekelab, Tesfalidet; Tekle, Dejen Yemane; Shifa, Girma Temam; Temsah, Mohamad-Hani; Terkawi, Abdullah Sulieman; Tesema, Cheru Leshargie; Tesssema, Belay; Theis, Andrew; Thomas, Nihal; Thompson, Alex H.; Thomson, Alan J.; Thrift, Amanda G.; Tiruye, Tenaw Yimer; Tobe-Gai, Ruoyan; Tonelli, Marcello; Topor-Madry, Roman; Topouzis, Fotis; Tortajada, Miguel; Tran, Bach Xuan; Trujillo, Thomas Truelsen Ulises; Tsilimparis, Nikolaos; Tuem, Kald Beshir; Tuzcu, Emin Murat; Tyrovolas, Stefanos; Ukwaja, Kingsley Nnanna; Undurraga, Eduardo A.; Uthman, Olalekan A.; Uzochukwu, Benjamin S. Chudi; van Boven, Job F. M.; Varakin, Yuri Y.; Varughese, Santosh; Vasankari, Tommi; Vasconcelos, Ana Maria Nogales; Venketasubramanian, Narayanaswamy; Vidavalur, Ramesh; Violante, Francesco S.; Vishnu, Abhishek; Vladimirov, Sergey K.; Vlassov, Vasiliy Victorovich; Vollset, Stein Emil; Vos, Theo; Waid, Jillian L.; Wakayo, Tolassa; Wang, Yuan-Pang; Weichenthal, Scott; Weiderpass, Elisabete; Weintraub, Robert G.; Werdecker, Andrea; Wesana, Joshua; Wijeratne, Tissa; Wilkinson, James D.; Wiysonge, Charles Shey; Woldeyes, Belete Getahun; Wolfe, Charles D. A.; Workicho, Abdulhalik; Workie, Shimelash Bitew; Xavier, Denis; Xu, Gelin; Yaghoubi, Mohsen; Yakob, Bereket; Yalew, Ayalnesh Zemene; Yan, Lijing L.; Yano, Yuichiro; Yaseri, Mehdi; Ye, Pengpeng; Yimam, Hassen Hamid; Yip, Paul; Yirsaw, Biruck Desalegn; Yonemoto, Naohiro; Yoon, Seok-Jun; Yotebieng, Marcel; Younis, Mustafa Z.; Zaidi, Zoubida; Zaki, Maysaa El Sayed; Zeeb, Hajo; Zenebe, Zerihun Menlkalew; Zerfu, Taddese Alemu; Zhang, Anthony Lin; Zhang, Xueying; Zodpey, Sanjay; Zuhlke, Liesl Joanna; Lopez, Alan D.; Murray, Christopher J. L.
    Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016.
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    Outcomes for symptomatic non-obstructed individuals and individuals with mild (GOLD stage I) COPD in a population based cohort
    (2018) Perez-Padilla, Rogelio; Wehrmeister, Fernando C.; Montes de Oca, María; Lopez, Maria Victorina; Jardim, Jose R.; Muiño A.; Valdivia Cabrera, Gonzalo; Menezes A.M.B.
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    Prevalence of Sleep Related Symptoms in Four Latin American Cities
    (2008) Torre-Bouscoulet, Luis; Carlos Vazquez-Garcia, Juan; Muino, Adriana; Marquez, Maria; Victorina Lopez, Maria; Montes de Oca, Maria; Talamo, Carlos; Valdivia, Gonzalo; Pertuze, Julio; Menezes, Ana Maria B.; Perez-Padilla, Rogelio
    Study Objectives: to estimate the prevalence of the most common sleep related symptoms (SRS) in the metropolitan areas of Mexico City, Montevideo (Uruguay), Santiago (Chile), and Caracas (Venezuela).
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    Trajectories of Spirometric Patterns, Obstructive and PRISm, in a Population-Based Cohort in Latin America
    (2023) Perez-Padilla, Rogelio; de Oca, Maria Montes; Thirion-Romero, Ireri; Wehrmeister, Fernando C.; Lopez, Maria Victorina; Valdivia, Gonzalo; Jardim, Jose R.; Muino, Adriana; Menezes, Ana Maria B.; Perez-Padilla, Rogelio
    Background: Preserved ratio impaired spirometry (PRISm) has been associated with adverse outcomes and increased transition to other spirometric categories over time. We aimed to examine its prevalence, trajectories over time, and outcomes in a population-basedMethods: Data were obtained from two population-based surveys of adults from three cities in Latin America (PLATINO study), conducted on the same individuals 5-9 years after their baseline examination. We estimated the frequency of PRISm defined by FEV1 /FVC & GE;0.70 with FEV1 <80%, describing their clinical characteristics, longitudinal transition trajectories over time, factors associated with the transition.Results: At baseline, 2942 participants completed post-bronchodilator spirometry, and 2026 at both evaluations. The prevalence of normal spirometry was 78%, GOLD-stage 1 10.6%, GOLD 2-4 6.5%, and PRISm was: 5.0% (95% CI 4.2-5.8). PRISm was associated with less schooling, more reports of physician-diagnosis of COPD, wheezing, dyspnea, missing days at work, having & GE;2 exacerbations in the previous year but without accelerated lung function decline. Mortality risk was significantly higher in PRISm (HR 1.97, 95% CI 1.2-3.3) and COPD GOLD 1-4 categories (HR 1.79, 95% CI 1.3-2.4) compared with normal spirometry. PRISm at baseline most frequently transitioned to another category at follow-up (46.5%); 26.7% to normal spirometry and 19.8% to COPD. The best predictors of transition to COPD were closeness of FEV1/FVC to 0.70, older age, current smoking, and a longer FET in the second assessment.Conclusion: PRISm, is a heterogeneous and unstable condition prone to adverse outcomes that require adequate follow-up.