Browsing by Author "Perez, Nicolas"

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    A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
    (2021) Gomez-Puerta, Jose A.; Pons-Estel, Guillermo J.; Quintana, Rosana; Nieto, Romina; Serrano Morales, Rosa M.; Harvey, Guillermina B.; Wojdyla, Daniel; Scolnik, Marina; Funes Soaje, Carmen; Alba Moreyra, Paula; Novatti, Elisa; Arizpe, Fernando; Berbotto, Guillermo A.; Gonzalez Lucero, Luciana; Porta, Sabrina; Perez, Nicolas; Rodriguez, Anabella M.; Appenzeller, Simone; de Oliveira e Silva Montadon, Ana Carolina; Monticielo, Odirlei Andre; Cavalcanti, Fernando S.; Ribeiro, Francinne Machado; Borba, Eduardo F.; dos Reis-Neto, Edgard Torres; Neira, Oscar; Miguel Chahuan, Jose; Mimica, Milena; Aroca Martinez, Gustavo; Tobon, Gabriel J.; Vasquez, Gloria; Quintana-Lopez, Gerardo; Moreno Alvarez, Mario J.; Angel Saavedra, Miguel; Perez Cristobal, Mario; Fragoso-Loyo, Hilda; Amezcua-Guerra, Luis M.; Gonzalez-Bello, Yelitza C.; Abud-Mendoza, Carlos; Esquivel-Valerio, Jorge A.; Duarte, Margarita; Acosta Colman, Isabel; Mora-Trujillo, Claudia; Reategui-Sokolova, Cristina; Calvo Quiroz, Armando A.; Munoz-Louis, Roberto; Cairoli, Ernesto; Rosas, Iliana; Rebella, Martin; Cardiel, Mario H.; Garcia de la Torre, Ignacio; Catoggio, Luis J.; Alarcon, Graciela S.; Pons-Estel, Bernardo A.
    Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of "Lupus Investigators" in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
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    Exploration, mapping and characterization of filtration galleries of the Pica Oasis, northern Chile: A contribution to the knowledge of the Pica aquifer
    (2020) Lictevout, Elisabeth; Abellanosa, Carlos; Maass, Constanza; Perez, Nicolas; Yanez, Gonzalo; Veronique, Leonardi
    In arid areas, the efficient management of scarce water resources is key for population survival and development. One of the oldest and greatest ancient water management system in drylands is the filtration gallery. Originated from ancient Persia, they were spread to other regions and cultures, and are found in the oasis of Pica, in the Atacama Desert. A filtration gallery consists of an almost horizontal tunnel dug underground until it reaches a water-bearing zone. It allows to tap and drains out groundwater, and thus a direct contact with groundwater table. With the objective to understand groundwater processes, preserve the water and geoheritage of one of the driest places on Earth and improve land-use planning, the present work explored and studied the filtration galleries, locally called socavones, of the oasis of Pica. Through direct exploration, topographical survey and geo-electrical prospection, 24 socavones were identified, mapped and their main physical features described, showing common traits with filtration galleries described worldwide, but also proper features highlighting their originality. The findings of the geological and hydrogeological studies of the socavones, complemented by physical and chemical analysis, allow to identify new groundwater recharge processes and, thus, to review and complete the hydrogeological model of the local aquifer of Pica. Most socavones are abandoned today, owing to physical and socioeconomic changes. Nevertheless, this study concludes that they can still have a role to play in the groundwater management of this arid area.
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    OPA1 disease-causing mutants perturb mitochondrial nucleoid cluster distribution
    (ELSEVIER, 2022) Eisner, Veronica; Macuada, Josefa; Vidal, Gonzalo; Molina-Riquelme, Isidora; Aedo, Geraldine; Lagos, Daniel; Perez, Nicolas; Rudge, Timothy; Cartes-Saavedra, Benjamin