Browsing by Author "Paulos Arenas, Claudio"
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- ItemA description of patients presenting with minor illness in community pharmacies in southern Chile(2007) Akesson, C.; Paulos Arenas, Claudio; Marín, F.; Salazar, C.; Del Campo, C.H.
- ItemAntibiotic use in a medicine unit of a teaching hospital(1991) Domecq, C.; Paulos Arenas, Claudio; González Martín, Guillermo
- ItemDetermination of prednisolone and prednisone in plasma, whole blood, urine, and bound-to-plasma proteins by high-performance liquid chromatography(2005) Gai, M.N.; Pinilla, E.; Paulos Arenas, Claudio; Chávez, J.; Puelles, V.; Arancibia, A.
- ItemDISPOSITION OF NIFURTIMOX AND METABOLITE ACTIVITY AGAINST TRYPANOSOMA-CRUZI USING RAT ISOLATED-PERFUSED LIVER(1994) González‐Martin, G.; Paulos Arenas, Claudio; Guevara Zamudio, Alfredo Oscar; Ponce, G.
- ItemEffects of high altitude exposure on the pharmacokinetics of furosemide in healthy volunteers(2004) Arancibia, A.; Gai, M.N.; Paulos Arenas, Claudio; Chavez, J.; Pinilla, E.; Angel, N.; Ritschel, W.A.
- ItemEvaluation of an educational program on ambulatory patients consuming histamine H2-receptor antagonists(1991) Domecq, C.; Apud, P.; Paulos Arenas, Claudio
- ItemHigh-performance liquid chromatographic determination of nifurtimox in human serum(1988) Paulos Arenas, Claudio; Paredes, J.; Vasquez, I.; Kunze, G.; González Martín, Guillermo
- ItemImpact of a pharmaceutical care program in a community pharmacy on patients with dyslipidemia(2005) Paulos Arenas, Claudio; Nygren, C.E.A.; Celedon, Consuelo; Carcamo, Carina A.
- ItemLigand binding and kinetics of folate receptor recycling in vivo: Impact on receptor-mediated drug delivery(2004) Paulos Arenas, Claudio; Reddy, J.A.; Leamon, C.P.; Turk, M.J.; Low, P.S.
- ItemPopulation pharmacokinetics of amikacin in suspected cases of neonatal sepsis(Wiley, 2023) Severino Cuevas, Nicolás Felipe; Urzúa Baquedano, Maria Soledad; Ibacache Figueroa, Mauricio Enrique; Paulos Arenas, Claudio; Cortinez Fernandez, Luis Ignacio; Toso Milos, Alberto Antonio; Leguizamon Marino, Liliana Marcela; Inojosa Mackenzie, Fernanda; Maccioni Romero, Andrea Ana; Meza Cañas, Sebastián Jaime; Garcia, Andres; Ramirez, Marcelo; Von Mentlen Gutierrez, Catalina Paz; Ceballos Jorquera Javiera Nicol; Paredes Galvez, Noemi SarayAims:This study aimed to characterize the population pharmacokinetic parameters of intravenously administered amikacin in newborns and assess the effect of sepsis in amikacin exposure. Methods: Newborns aged >= 3 days who received at least 1 dose of amikacin during their hospitalization period were eligible for the study. Amikacin was administered intravenously during a 60-min infusion period. Three venous blood samples were taken from each patient during the first 48 h. Population pharmacokinetic parameter estimates were obtained using a population approach with the programme NONMEM. ResultsData from 329 drug assay samples were obtained from 116 newborn patients (postmenstrual age [PMA] 38.3, range 32-42.4 weeks; weight 2.8, range 1.6-3.8 kg). Measured amikacin concentrations ranged from 0.8 to 56.4 mg/L. A 2-compartment model with linear elimination produced a good fit of the data. Estimated parameters for a typical subject (2.8 kg, 38.3 weeks) were clearance (Cl = 0.16 L/h), intercompartmental clearance (Q = 0.15 L/h), volume of distribution of the central compartment (Vc = 0.98 L) and peripheral volume of distribution (Vp = 1.23 L). Total bodyweight, PMA and the presence of sepsis positively influenced Cl. Plasma creatinine concentration and circulatory instability (shock) negatively influenced Cl. ConclusionOur main results confirm previous findings showing that weight, PMA and renal function are relevant factors influencing newborn amikacin pharmacokinetics. In addition, current results showed that pathophysiological states of critically ill neonates, such as sepsis and shock, were associated with opposite effects in amikacin clearance and should be considered in dose adjustments.
- ItemThe pharmacokinetics of nifurtimox in chronic renal failure(1992) González Martín, Guillermo; Thambo, S.; Paulos Arenas, Claudio; Vásquez, I.; Paredes, Judith