Browsing by Author "Patel, Sanjay"

Now showing 1 - 7 of 7
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    Antiplatelet Therapy and Percutaneous Coronary Interventions
    (BENTHAM SCIENCE PUBL LTD, 2021) Davanzo, Rene Hameau; Alarcon, Alberto Fuensalida; Calquin, Jorge Quitral; Varela, Pablo Sepulveda; Sepulveda, Alejandro Martinez; Herreros, Ramon Corbalan; Patel, Sanjay; Rodriguez, Gonzalo Martinez
    Dual antiplatelet therapy is one of the cornerstones of modern percutaneous coronary interventions. The development of new therapeutic agents has significantly reduced ischemic events at the risk of increased bleeding complications. Therefore, efforts are currently focused on optimizing therapeutic algorithms to obtain the greatest anti-thrombotic benefit associated with the lowest risk of bleeding, that is, the greater net clinical benefit.
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    Association between ideal cardiovascular health and markers of subclinical cardiovascular disease
    (2018) Shpilsky, Daniel; Bambs S., Claudia; Kip, Kevin; Patel, Sanjay; Aiyer, Aryan; Olafiranye, Oladipupo; Reis, Steven E.; Erqou, Sebhat
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    Association between spontaneous internal carotid artery dissection and perivascular adipose tissue attenuation on computed tomography angiography
    (2023) Cheng, Kevin; Lin, Andrew; Stecher, Ximena; Bernstein, Tomas; Zuniga, Paulo; Mazzon, Enrico; Brunser, Alejandro; Diaz, Violeta; Martinez, Gonzalo; Cameron, William; Nicholls, Stephen J.; Patel, Sanjay; Dey, Damini; Wong, Dennis T. L.; Venturelli, Paula Munoz
    Background: Spontaneous cervical artery dissection (sCAD) is a leading cause of ischemic stroke in young patients. Studies using high-resolution magnetic resonance imaging and positron emission tomography have suggested vessel wall inflammation to be a pathogenic factor in sCAD. Computed tomography (CT) attenuation of perivascular adipose tissue (PVAT) is an established non-invasive imaging biomarker of inflammation in coronary arteries, with higher attenuation values reflecting a greater degree of vascular inflammation. Objectives: We evaluate the CT attenuation of PVAT surrounding the internal carotid artery (PVAT(carotid)) with and without spontaneous dissection. Methods: Single-center prospective observational study of 56 consecutive patients with CT-verified spontaneous dissection of the internal carotid artery (ICA). Of these patients, six underwent follow-up computed tomography angiography (CTA). Twenty-two patients who underwent CTA for acute neurological symptoms but did not have dissection formed the control group. Using semi-automated research software, PVAT(carotid) was measured as the mean Hounsfield unit (HU) attenuation of adipose tissue within a defined volume of interest surrounding the ICA. Results: PVAT(carotid) was significantly higher around dissected ICA compared with non-dissected contralateral ICA in the same patients (-58.7 +/- 10.2 vs -68.9 +/- 8.1 HU, p < 0.0001) and ICA of patients without dissection (-58.7 +/- 10.2 vs -69.3 +/- 9.3 HU, p < 0.0001). After a median follow-up of 89 days, there was a significant reduction in PVAT(carotid) around dissected ICA (-57.5 +/- 13.4 to -74.3 +/- 10.5 HU, p < 0.05), while no change was observed around non-dissected contralateral ICA (-71.0 +/- 4.4 to -74.1 +/- 4.1 HU, p = 0.19). ICA dissection was an independent predictor of PVAT(carotid) following multivariable adjustment for age and the presence of ICA occlusion. Conclusion: PVAT(carotid) is elevated in the presence of sCAD and may decrease following the acute event.
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    Colchicine as a Novel Therapy for Suppressing Chemokine Production in Patients With an Acute Coronary Syndrome : A Pilot Study
    (2019) Tucker, Bradley; Kurup, Rahul; Barraclough, Jennifer; Henriquez, Rodney; Cartland, Siân; Arnott, Clare; Misra, Ashish; Martínez, Gonzalo; Kavurma, Mary; Patel, Sanjay
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    Transcoronary gradients of HDL-associated MicroRNAs in unstable coronary artery disease
    (2018) Choteau, Sebastien A.; Cuesta Torres, Luisa F. ; Barraclough, Jennifer Y.; Elder, Alexander M. M.; Martínez, Gonzalo; Chen Fan, William Y. ; Shrestha, Sudichhya; Ong, Kwok L.; Barter, Philip J.; Celermajer, David S.; Rye, Kerry-Anne; Patel, Sanjay