Browsing by Author "Paredes Sabja, Daniel"
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- ItemAtypical presentation of pseudomembranous colitis localized in adenomatous polyps(2013) Hernández Rocha, Cristián Antonio; Barra Carrasco, Jonathan Eduardo; Guzmán Durán, Ana María; Paredes Sabja, Daniel; Lezcano, Gabriel; Zoroquiain Vélez, José Pablo; Álvarez Lobos, Manuel
- ItemCharacterization of Chicken IgY Specific to Clostridium difficile R20291 Spores and the Effect of Oral Administration in Mouse Models of Initiation and Recurrent Disease(2017) Pizarro Guajardo, Marjorie; Díaz González, Fernando; Álvarez Lobos, Manuel; Paredes Sabja, Daniel
- ItemClostridium difficile associated infections: an updated view(SOC CHILENA INFECTOLOGIA, 2012) Hernandez Rocha, Cristian; Naour, Sebastian; Alvarez Lobos, Manuel; Paredes Sabja, DanielClostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of similar to 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. difficile associated infections (CDAI) is similar to 1% of total hospitalized patients. CDAI has a mortality rate of similar to 1 to 5%, and a relapse rate of similar to 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. difficile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.
- ItemRendimiento de índices pronósticos en infección asociada a Clostridium difficile grave. Análisis retrospectivo en un hospital universitario(2014) Hernández Rocha, Cristián Antonio; Tejos Sufan, Rodrigo; Plaza Garrido, Ángela; Barra Carrasco, Jonathan Eduardo; Agüero Luengo, Carlos; Inostroza Levy, Gonzalo; Ibáñez Lazo, Patricio Fernando; Guzmán Durán, Ana María; Álvarez Lobos, Manuel; Molina Pezoa, María Elena; Paredes Sabja, Daniel