Browsing by Author "Pardo, F"

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    Fertilisation involving ageing gametes, major birth defects, and Down's syndrome
    (2002) Simpson, JL; Gray, R; Perez, A; Mena, P; Queenan, J; Barbato, M; Pardo, F; Kambic, R; Jennings, V
    For many years, ageing of gametes as a result of prolonged retention In the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies In 11 l of 400 Infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 Infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of Infants with Down's syndrome were two l of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, Including Down's syndrome.
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    Further evidence that infection is an infrequent cause of first trimester spontaneous abortion
    (1996) Simpson, JL; Gray, RH; Queenan, JT; Barbato, M; Perez, A; Mena, P; Kambic, RT; Pardo, F; Stevenson, W; Li, CJ; Jennings, V
    A previous cohort study found pro clinical evidence that infection occurred more often in subjects experiencing pregnancy loss compared with those experiencing successful pregnancy [Simpson et al. (1996) Hum. Reprod, 11, 668-672]. Given these surprising findings, we conducted a similar analysis on another cohort arise followed prospectively. Using couples practising natural family planning for conception or contraception, information on clinical evidence of infection was gathered beginning with week 5 of gestation. Information on fever and signs of overt infection was specifically sought by interview and physical examination. Frequencies of urinary, vaginal and other infections in subjects experiencing pregnancy loss were 11.1, 9.5 and 8.7% respectively, not significantly different from rates in subjects having liveborns (10.1, 10.2 and 10.3% respectively). Thus, no association between clinical infection and early pregnancy loss (less than or equal to 16 weeks) was observed, Cohere studies utilizing biologically based assays are awaited because extant data do not provide evidence that clinically evident infections play major roles in first trimester pregnancy losses.