Browsing by Author "Paiva, Carlos Eduardo"

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    Factors Associated With Attrition in a Multicenter Longitudinal Observational Study of Patients With Advanced Cancer
    (2018) Pérez Cruz, Pedro; Shamieh, Omar; Paiva, Carlos Eduardo; Kwon, Jung Hye; Muckaden, Mary Ann; Bruera, Eduardo; Hui, David
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    How to Advance Palliative Care Research in South America? Findings From a Delphi Study
    (2023) Paiva, Carlos Eduardo; Bonilla-Sierra, Patricia; Tripodoro, Vilma Adriana; Rodriguez-Nunez, Alfredo; De Simone, Gustavo; Rodriguez, Liliana Haydee; Vidal, Edison Iglesias de Oliveira; Rios, Miriam Riveros; Crispim, Douglas Henrique; Perrez-Cruz, Pedro; Nascimento, Maria Salete de Angelis; Ospina, Paola Marcela Ruiz; de Lima, Liliana; Pastrana, Tania; Zimmerman, Camilla; Hui, David; Bruera, Eduardo; Paiva, Bianca Sakamoto Ribeiro
    Context. Progress in palliative care (PC) necessarily involves scientific development. However, research conducted in South America (SA) needs to be improved.Objectives. To develop a set of recommendations to advance PC research in SA.Methods. Eighteen international PC experts participated in a Delphi study. In round one, items were developed (open-ended questions); in round two, each expert scored the importance of each item (from 0 to 10); in round three, they selected the 20 most relevant items. Throughout the rounds, the five main priority themes for research in SA were defined. In Round three, consensus was defined as an agreement of >= 75%. Results. 60 potential suggestions for overcoming research barriers in PC were developed in round one. Also in Round one, 88.2% (15 of 17) of the experts agreed to define a priority research agenda. In Round two, the 36 most relevant suggestions were defined and a new one added. Potential research priorities were investigated (open-ended). In Round three, from the 37 items, 10 were considered the most important. Regarding research priorities, symptom control, PC in primary care, public poli-cies, education and prognosis were defined as the most relevant.Conclusion. Potential strategies to improve scientific research on PC in SA were defined, including stimulating the formation of collaborative research networks, offering courses and workshops on research, structuring centers with infrastructure resour-ces and trained researchers, and lobbying governmental organizations to convince about the importance of palliative care. In addition, priority research topics were identified in the region. J Pain Symptom Manage 2023;65:193-202. (c) 2022 The Authors. Published by Elsevier Inc. on behalf of American Academy of Hospice and Palliative Medicine. This is an open access article under the CC BY -NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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    Meaning in life in patients with advanced cancer: a multinational study
    (2020) Gravier, Anna L.; Shamieh, Omar; Paiva, Carlos Eduardo; Perez-Cruz, Pedro Emilio; Muckaden, Mary Ann; Park, Minjeong; Bruera, Eduardo; Hui, David
    Background Few studies have examined meaning in life, a novel existential outcome, in patients with advanced cancer across countries. Objectives We examined differences in meaning in life across 5 countries and identified factors associated with meaning in life. Methods This is a pre-planned secondary analysis of a prospective longitudinal multicenter observational study of patients with advanced cancer. Meaning in life was assessed using a validated scale which examined four domains of meaning: values, purpose, goals, and reflection. The total score ranged from 8 to 32, with a higher score indicating greater meaning in life. Results Among 728 patients, the median meaning in life score was 25/32 (interquartile range 23, 28). There was no significant difference in the total meaning in life score among 5 countries (P = 0.11), though there were differences in domain sub-scores. In the univariate analysis, patients with higher intensity of physical symptoms by ESAS score (pain, fatigue, drowsiness, dyspnea, insomnia), depression, anxiety, spiritual pain, and financial distress had significantly lower meaning in life. However, patients with higher levels of education, who were married, and who had higher optimism had significantly higher meaning in life. In the multivariate analysis, higher total meaning in life scores were significantly associated with greater optimism (multivariate estimate = 0.33,p < 0.001), lower depression (- 0.26, < 0.001), spiritual pain (- 0.19, < 0.001), and financial distress (- 0.16, < 0.001). Conclusion Country of origin was not a determinant of meaning in life. However, meaning in life was significantly associated with optimism, depression, spiritual pain, and financial distress, underscoring the multidimensional nature of this construct and potential opportunities for improvement in addressing meaning in life of patients with advanced cancer.
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    Personalized symptom goals and response in patients with advanced cancer
    (2016) Hui, David; Park, Minjeong; Shamieh, Omar; Paiva, Carlos Eduardo; Pérez Cruz, Pedro; Muckaden, Mary Ann; Bruera, Eduardo
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    The Impact of International Research Collaborations on the Citation Metrics and the Scientific Potential of South American Palliative Care Research: Bibliometric Analysis
    (2021) Lima, Crislaine de; Sakamoto Ribeiro Paiva, Bianca; Neto, Martins Fideles dos Santos; Hui, David; Pérez Cruz, Pedro; Zimmermann, Camilla; Bruera, Eduardo; Paiva, Carlos Eduardo
    Background: Progress in palliative care (PC) requires scientific advances which could potentially be catalyzed by international research collaboration (IRC). It is currently not known how often IRC occurs with PC investigators in South America. Objectives: To evaluate the percentage of South America journal articles on PC involving IRCs and the impact of these collaborations on the scientific potential the studies and on their citations. Methods: This was a bibliometric analysis of studies published between January 1, 1998, and December 31, 2017. A search of Pubmed, Embase, Lilacs, and Web of Science (WOS) was performed using the terms “palliative care,” “hospice care,” “hospices” and “terminal care,” combined with the name of South America countries. The scientific potential was assessed by analyzing study design, characteristics of the journal and funding. IRCs were further subdivided in internal (within South America countries) and external (with countries outside South America). Findings: Of the 641 articles, 117 (18.2%) involved IRCs (internal: 18, 2.8%; external: 110, 17.2%). Articles with IRCs had higher median two-year citations in WOS (2 vs. 1, p < 0.001), Scopus (3 vs. 1, p < 0.001) and Google Scholar (4.5 vs. 2, p < 0.001) compared to articles without IRC. Moreover, they were more often funded (40.7% vs. 9.7%, p < 0.001), published in Pubmed-indexed (76.1% vs. 41.6%; p < 0.001) and in WOS-indexed (70.1% vs. 29.6%; p < 0.001) journals, and with study designs most often classified as clinical trial (5.1% vs. 1.0%; p = 0.002) and cohort (10.3% vs. 2.9%; p < 0.001) compared to articles without IRC. Conclusions: Studies with international research collaborations, both internal and external to South America, are more frequently cited and have characteristics with greater scientific potential than do studies without international collaborations.