Browsing by Author "Pais, Edgard"

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    Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients
    (2022) Torres, Ruben; Toro, Luis; Eugenia Sanhueza, Maria; Lorca, Eduardo; Ortiz, Mireya; Pefaur, Jacqueline; Clavero, Rene; Machuca, Eduardo; Gonzalez, Fernando; Herrera, Patricia; Mocarquer, Alfredo; Frias, Alondra; Roessler, Eric; Munoz, Carolina; Nunez, Miguel; Aravena, Cesar; Quintana, Enrique; Lemus, Juan; Lillo, Mario; Reynolds, Enrique; Morales, Alvaro; Pais, Edgard; Fiabane, Andrea; Parra-Lucares, Alfredo; Garrido, Cristian; Mendez-Valdes, Gabriel; Villa, Eduardo; Mansilla, Rodrigo; Sotomayor, Germana; Gonzalez, Marcela; Miranda, Cecilia; Briones, Eduardo; Gomez, Esteban; Mezzano, Sergio; Bernales, Waldo; Rocca, Ximena; Espinoza, Oscar; Zuniga, Eric; Aragon, Henry; Badilla, Marta; Valenzuela, Marcela; Escobar, Luis; Zamora, Daniela; Flores, Ivan; Tapia, Beatriz; Borquez, Tamara; Herrera, Patricio
    Introduction: The COVID-19 pandemic is a global public health problem. Patients with end-stage renal disease on hemodialysis are at a higher risk of infection and mortality than the general population. Worldwide, a vaccination campaign has been developed that has been shown to reduce severe infections and deaths in the general population. However, there are currently limited data on the clinical efficacy of vaccinations in the hemodialysis population.
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    Effect of the covid-19 pandemic on the frequency of glomerular diseases in a population with low prevalence of apol1 risk variants : WCN24-2633
    (2024) Valjalo, Ricardo; Villalobos, Arturo; Ruiz, Andrea; Segura, Paula; Ávila Jiménez, Eduardo Rodolfo; Fulgeri, Celeste; Musalem, Pilar; Navarro, Fernando; Pais, Edgard; Cordero, Carolina; Mansilla, Rodrigo; Reynolds, Enrique; Contreras, Francisco; Hellman, Elizabeth; Año, Agustín; Hernández, María
    Different glomerular diseases have been reported in people with COVID-19 and/or after vaccination against SARS-CoV-2, with the development of collapsing FSGS being observed more frequently in populations with high-risk APOL1 genotypes. However, a causal link between glomerular diseases and COVID-19 infection or its vaccine is not firmly established. To evaluate the real impact of the COVID-19 pandemic on the epidemiology of glomerular diseases, we conducted a retrospective multicenter study analyzing the clinical manifestations and histological findings in renal biopsies during the pre-pandemic and pandemic period.
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    Survival study and factors associated with mortality in Chilean patients on peritoneal dialysis infected with SARS-CoV-2
    (2022) Ortiz, Ana M.; Sepulveda Palamara, Rodrigo Andres; Torres, Ruben; Clavero, Rene; Toro, Luis; Albornoz, Miguel; Aldunate, Tatiana; Arce, Ingrid; Arevalo, Juan; Arriagada, Andres; Becker, Julieta; Gonzalez, Sonia C.; Bernales, Waldo; Briones, Eduardo; Castillo, Alvaro; Fuentes, Agustin; Gomez, Esteban; Jaramillo, Hernan; Lillo, Mario; Lorca, Eduardo; Machuca, Eduardo; Mansilla, Rodrigo; Menendez, Serwin; Moya, Carlos; Munoz, Carolina; Neilson, William; Orozco, Rodrigo; Padrino, Maria; Pais, Edgard; Ramirez, Gonzalo; Sanhueza, Maria E.; Schneider, Herman; Solis, Ruth; Troncoso, Jaime; Ursu, Marcela; Valenzuela, Marcela
    The Covid-19 pandemic has been responsible for millions of deaths worldwide. Patients with comorbidities- such as those on peritoneal dialysis (PD)- present higher morbidity and mortality than the general population. We prospectively evaluated all Chilean patients on PD (48 centres) and followed those who had Covid-19 from the beginning of the Covid-19 pandemic in Chile (March 2020) to January 2021 (start of vaccination campaign). We described demographic history, comorbidities, factors related to infection, need for hospitalisation and death due to Covid-19. During the study period, 106 adults on PD were infected by SARS-CoV-2, with a mean age of 53.1 (+/- 16.3) and of which 53.9% were female. From that group, 54.8% required hospitalisation and 24.5% (n = 26) died due to Covid-19. Most of the patients (63.4%) were infected at home and 22.8% during hospitalisation for other reasons. There was a significant association for Covid-19 mortality with: being >= 60 years old, diabetes, time on PD >= 5 years, need for hospitalisation and hospital-acquired infection. At 90 days of follow-up, all deaths associated to Covid-19 occurred before 40 days. We conclude that patients on PD without Covid-19 vaccination have a high mortality and need for hospitalisation associated to Covid-19. To avoid this negative outcome, it is necessary to intensify strategies to avoid contagion, especially in those >= 60 years old, with diabetes and/or >= 5 years spent on PD.