Browsing by Author "Pacheco, E."

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    To ignore or not to ignore: The differential effect of coping mechanisms on depressive symptoms when facing adolescent cyberbullying
    (2022) Varela, J.J.; Hernández, C.; Berger Silva, Christian; Souza, S.B.; Pacheco, E.
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    Trombofilia primaria: detección y manifestación clínica en 105 casos
    (SOC MEDICA SANTIAGO, 2004) Srur, E.; Vargas, C.; Salas, S.; Parra, J.A.; Bianchi, V.; Mezzano, D.; Munoz, B.; Vasquez, M.; Pacheco, E.
    Background: Thrombophilia is defined as an altered hemostasis that predisposes to thrombosis. It can be primary when there is a family clustering of the disease or secondary, when it is associated to an acquired risk factor. Aim: to report clinical features in a series of patients with primary thrombophilia. Material and methods: Review of clinical records of patients with thrombotic episodes that lead to the suspicios of primary thrombophilia. Analysis of asymptomatic adult close relatives of these patients. Results: We repot 93 subjects (56 females, age range 14-77 years) with repeated episodes of thrombosis and a family history of thrombosis. Twenty four percent had protein C deficiency, 24% had antithrombin III deficiency, 18% had resistance to activated C protein by factor V Leiden, 10% had protein S deficiency, and 10% had the G20210 mutation of prothrombin gene. Among acquired defects studied simultaneously, 30% had lupus anticoagulent and 11% had hyperhomocysteinemia. Twenty four percent of cases had more than one thrombophilic risk factor. Among asymptomatic relatives, five had factor V Leiden, four had protein C deficiency and three had the G20210 mutation of prothrombin gene. Conclusions: Thrombophilia must be suspected in young subjects with thrombotic episode and a family history. the type of coagulation defect will determine prognosis, and the type of treatment (Rev Med Chile 2004; 132: 1466-73).