Browsing by Author "Oyarzun, Enrique"

Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
    (MOSBY-ELSEVIER, 2010) Romero, Roberto; Friel, Lara A.; Edwards, Digna R. Velez; Kusanovic, Juan Pedro; Hassan, Sonia S.; Mazaki Tovi, Shali; Vaisbuch, Edi; Kim, Chong Jai; Erez, Offer; Chaiworapongsa, Tinnakorn; Pearce, Brad D.; Bartlett, Jacquelaine; Salisbury, Benjamin A.; Anant, Madan Kumar; Vovis, Gerald F.; Lee, Min Seob; Gomez, Ricardo; Behnke, Ernesto; Oyarzun, Enrique; Tromp, Gerard; Williams, Scott M.; Menon, Ramkumar
    OBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM).
  • Thumbnail Image
    Item
    Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods
    (WALTER DE GRUYTER GMBH, 2010) DiGiulio, Daniel B.; Gervasi, MariaTeresa; Romero, Roberto; Mazaki Tovi, Shali; Vaisbuch, Edi; Kusanovic, Juan Pedro; Seok, Kimberley S.; Gomez, Ricardo; Mittal, Pooja; Gotsch, Francesca; Chaiworapongsa, Tinnakorn; Oyarzun, Enrique; Kim, Chong Jai; Relman, David A.
    Objective: Infection has been implicated in the pathogenesis of preeclampsia, yet the association between microbial invasion of the amniotic cavity (MIAC) and preeclampsia has not been determined. The aim of this study was to determine the prevalence, and microbial diversity associated with MIAC, as well as the nature of the host response to MIAC in patients with preeclampsia.
  • Thumbnail Image
    Item
    Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses
    (WALTER DE GRUYTER GMBH, 2010) DiGiulio, Daniel B.; Gervasi, Maria Teresa; Romero, Roberto; Vaisbuch, Edi; Mazaki Tovi, Shali; Kusanovic, Juan Pedro; Seok, Kimberley S.; Gomez, Ricardo; Mittal, Pooja; Gotsch, Francesca; Chaiworapongsa, Tinnakorn; Oyarzun, Enrique; Kim, Chong Jai; Relman, David A.
    Objective: Microbial invasion of the amniotic cavity (MIAC) has been detected in women with preterm labor, preterm prelabor rupture of membranes (PROM), and in patients at term with PROM or in spontaneous labor. Intrauterine infection is recognized as a potential cause of fetal growth restriction; yet, the frequency of MIAC in pregnancies with small-for-gestational-age (SGA) fetuses is unknown. The aim of this study was to determine the frequency, diversity and relative abundance of microbes in amniotic fluid (AF) of women with an SGA neonate using a combination of culture and molecular methods.
  • Thumbnail Image
    Item
    Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age
    (TAYLOR & FRANCIS LTD, 2011) Edwards, Digna R. Velez; Romero, Roberto; Kusanovic, Juan Pedro; Hassan, Sonia S.; Mazaki Tovi, Shali; Vaisbuch, Edi; Kim, Chong Jai; Erez, Offer; Chaiworapongsa, Tinnakorn; Pearce, Brad D.; Bartlett, Jacquelaine; Friel, Lara A.; Salisbury, Benjamin A.; Anant, Madan Kumar; Vovis, Gerald F.; Lee, Min Seob; Gomez, Ricardo; Behnke, Ernesto; Oyarzun, Enrique; Tromp, Gerard; Menon, Ramkumar; Williams, Scott M.
    Objective. To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA).
  • No Thumbnail Available
    Item
    Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
    (AMER ASSOC IMMUNOLOGISTS, 2010) Cardenas, Ingrid; Means, Robert E.; Aldo, Paulomi; Koga, Kaori; Lang, Sabine M.; Booth, Carmen; Manzur, Alejandro; Oyarzun, Enrique; Romero, Roberto; Mor, Gil
    Pandemics pose a more significant threat to pregnant women than to the nonpregnant population and may have a detrimental effect on the well being of the fetus. We have developed an animal model to evaluate the consequences of a viral infection characterized by lack of fetal transmission. The experiments described in this work show that viral infection of the placenta can elicit a fetal inflammatory response that, in turn, can cause organ damage and potentially downstream developmental deficiencies. Furthermore, we demonstrate that viral infection of the placenta may sensitize the pregnant mother to bacterial products and promote preterm labor. It is critical to take into consideration the fact that during pregnancy it is not only the maternal immune system responding, but also the fetal/placental unit. Our results further support the immunological role of the placenta and the fetus affecting the global response of the mother to microbial infections. This is relevant for making decisions associated with treatment and prevention during pandemics. The Journal of Immunology, 2010, 185: 1248-1257.