Browsing by Author "Orellana, Myriam"

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    Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
    (2008) Faúndez Cáceres, Mario; Lopez-Munoz, Rodrigo; Torres, Gloria; Morello, Antonio; Ferreira, Jorge; Kemmerling, Ulrike; Orellana, Myriam; Maya, Juan D.
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    Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms
    (PERGAMON-ELSEVIER SCIENCE LTD, 2008) Salas, Cristian; Tapia, Ricardo A.; Ciudad, Karina; Armstrong, Veronica; Orellana, Myriam; Kemmerling, Ulrike; Ferreira, Jorge; Maya, Juan Diego; Morello, Antonio
    Derivatives of natural quinones with biological activities, such as lapachol, alpha- and beta-lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma cruzi cells. All tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity as compared with current trypanocidal drugs, nifurtimox and benznidazole. The results presented here show that the anti-T Cruzi activity of the alpha-lapachone derivatives can be increased by the replacement of the benzene ring by a pyridine moiety. Free radical production and consequently oxidative stress through redox cycling or production of electrophilic metabolites are the potential biological mechanism of action for these synthetic quinones. (c) 2007 Elsevier Ltd. All rights reserved.
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    Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
    (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010) Lopez Munoz, Rodrigo; Faundez, Mario; Klein, Sebastian; Escanilla, Sebastian; Torres, Gloria; Lee Liu, Dasfne; Ferreira, Jorge; Kemmerling, Ulrike; Orellana, Myriam; Morello, Antonio; Ferreira, Arturo; Maya, Juan D.
    Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T cruzi infected macrophages mount an antiparasitic response, which the parasite evades through an increase of tumor growth factor beta and PGE(2) activation as well as decreased iNOS activity. Thus, prostaglandin synthesis inhibition with aspirin might increase macrophage antiparasitic activity and increase nifurtimox and benznidazole effect.