Browsing by Author "Olmos, Roberto I."

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    A new physiopathological classification of diabetic neuropathy
    (SOC MEDICA SANTIAGO, 2012) Olmos, Pablo R.; Niklitschek, Sergio; Olmos, Roberto I.; Faundez, Jorge I.; Quezada, Thomas A.; Bozinovic, Milan A.; Niklitscheka, Ian A.; Acosta, Jorge; Valencia, Claudio N.; Bravo, Felipe A.
    Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications of diabetes and related to treatment. It must be understood that DN is not just a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN. (Rev Med Chile 2012; 140: 1593-1605).
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    Near-optimal glycemic control in Chilean women with pregestational type-2 diabetes: Persistent macrosomia relates to maternal pre-pregnancy overweight
    (ELSEVIER IRELAND LTD, 2009) Olmos, Pablo R.; Araya Del Pino, Andrea P.; Gonzalez Carvello, Cristian A.; Laso Ulloa, Pablo; Hodgson, Maria I.; Irribarra, Veronica; Borzone, Gisella R.; Belmar, Cristian; Poblete, Andres; Berrios, Cecilia; Becker, Jorge; Zajer Amar, Claudia M.; Manzur, Alejandro; Bozinovic, Milan; Miranda, Ramon J.; Diez, Alberto; Vidal, Hernan; Ramirez Armijo, Renato; Olmos, Roberto I.; Tabilo, Cristian; Ahuad, Jessica
    After a 10-year program intending to improve glycemic control in diabetic pregnancies, we evaluated whether factors underlying macrosomia are similar for type-1 and -2 pregestational diabetic women.