Browsing by Author "Ojeda-Gomez, Claudia"

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    Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter
    (2014) Ojeda-Gomez, Claudia; Pessoa-Mahana, Hernan; Iturriaga-Vasquez, Patricio; David Pessoa-Mahana, Carlos; Recabarren-Gajardo, Gonzalo; Mendez-Rojas, Claudio
    A series of functionalized indolylalkylarenes 3-16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3-12(a and b) were obtained by nucleophilic substitution of 3-(1H-indol-3-yl)propyl-4-methylbenzenesulfonates 2(a and b) with a series of azaheterocycles. Compounds 14-16(a and b) were prepared in a two-step sequence by reaction of 3-(1H-indol-3-yl)-2-methylpropanal with substituted 1,2-phenylenediamines. Compounds 3b, 4b, and 5b showed good binding affinities (K-i=33.0, 48.0, and 17nM, respectively). The other synthesized compounds showed moderate or no affinity in the binding studies.