Browsing by Author "Nien, JK"

Now showing 1 - 5 of 5
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    A short cervix in women with preterm labor and intact membranes: A risk factor for microbial invasion of the amniotic cavity
    (MOSBY-ELSEVIER, 2005) Gomez, R; Romero, R; Nien, JK; Chaiworapongsa, T; Medina, L; Kim, YM; Yoon, BH; Carstens, M; Espinoza, J; Iams, JD; Gonzalez, R
    Objective: The purpose of this study was to determine whether there was a relationship between sonographic cervical length and the presence of culture-proven microbial invasion of the ammotic cavity in women with preterm labor and intact membranes.
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    A sonographic short cervix as the only clinical manifestation of intra-amniotic infection
    (2006) Hassan, S; Romero, R; Hendler, I; Gomez, R; Khalek, N; Espinoza, J; Nien, JK; Berry, SM; Bujold, E; Camacho, N; Sorokin, Y
    Objective: A sonographically short cervix is a powerful predictor of spontaneous preterm delivery. However, the etiology and optimal management of a patient with a short cervix in the mid-trimester of pregnancy remain uncertain. Microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation are frequently present in patients with spontaneous preterm labor or acute cervical insufficiency. This study was conducted to determine the rate of MIAC and intra-amniotic inflammation in patients with a cervical length < 25 mm in the mid-trimester.
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    Cerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve
    (1998) Nien, JK; Schmidt, J; Cartier, L; Alvarez, J
    HTLV-1 (human T-cell leukemia virus type I) associated myelopathy (HAM) is a demyelinating disease. We showed that the CSF of patients and heated CSF of normal subjects induce a segmentary demyelination in rat nerves, and potentiate trypsin in vitro. Here we further characterize the neuropathy induced by the CSF of patients. Peroneal nerves injected 5-8 days before with native or heated CSF of patients, besides extensive demyelination, presented proliferation of myelinating and nonmyelinating Schwann cells, axonal sprouting, fine fibres with a few turns of myelin, disarray of nonmedullated bundles, desmosome-like junctions, and coated pits and vesicles in Schwann cells and axons. The normal CSF was innocuous to the nerve in its native form, but after heating, it induced a neuropathy in all, similar to that elicited by the CSF of patients. Our findings indicate that the CSF of HAM patients contains a thermostable pathogen for nerves of the rat; a thermostable pathogen also occurs in the normal CSF although its activity is checked by endogenous thermolabile factors. We suggest that the pathogen present in the CSF of HAM patients participates in the disease. (C) 1998 Elsevier Science B.V. All rights reserved.
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    Idiopathic vaginal bleeding during pregnancy as the only clinical manifestation of intrauterine infection
    (TAYLOR & FRANCIS LTD, 2005) Gomez, R; Romero, R; Nien, JK; Medina, L; Carstens, M; Kim, YM; Chaiworapongsa, T; Espinoza, J; Gonzalez, R
    Objective. To determine the frequency and clinical significance of microbial invasion of the amniotic cavity (MIAC) in patients with vaginal bleeding in the absence of placenta previa, preterm labor or preterm premature rupture of membranes (PROM).
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    The prevalence and clinical significance of amniotic fluid 'sludge' in patients with preterm labor and intact membranes
    (WILEY, 2005) Espinoza, J; Goncalves, LF; Romero, R; Nien, JK; Stites, S; Kim, YM; Hassan, S; Gomez, R; Yoon, BH; Chaiworapongsa, T; Lee, W; Mazor, M
    Objective To determine the prevalence and clinical significance of amniotic fluid (AF) 'sludge' observed during transvaginal ultrasound examination of the cervix in patients with preterm labor and intact membranes, and in those with uncomplicated pregnancies.