Browsing by Author "Nervi, Flavio"
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- ItemDeficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice(2010) Morales France, María Gabriela; Amigo Böker, Ludwig Peter; Balboa Castillo, Elisa Ivana; Acuña Aravena, Mariana Loreto; Castro, Juan; Molina, Héctor; Miquel P., Juan Francisco; Nervi, Flavio; Rigotti Rivera, Attilio; Zanlungo Matsuhiro, Silvana
- ItemEscala numérica para evaluar síntomas espirituales en cuidados paliativos(2017) Bonati, P.; Nervi, Flavio; Reyes, M.; De Lima, L.; Taboada R., Paulina; Villarroel del Pino, Luis A.; Vial Correa, Juan de Dios; Blanco, O.; González, Rina; Parra, I.; Toledo, G.
- ItemIsolation and Purification of Human Biliary Vesicles With Potent Cholesterol Nucleation-Promoting Activity(1992) Brandan, Enrique; Miquel P., Juan Francisco; Nervi, Flavio; Rigotti Rivera, Attilio
- ItemMutagenic substances in red and white wine in Chile, a high risk area for gastric cancer(1987) Bull Simpfendorfer, Paulina; Nervi, Flavio
- ItemRisk Factors and Pathogenesis of Cholesterol Gallstones: State of the Art(1999) Amigo, Ludwid; Zanlungo Matsuhiro, Silvana; Mendoza Vilches, Hegaly Lenny; Miquel P., Juan Francisco; Nervi, FlavioThe aim of this article is to present an update of selected aspects of the pathogenesis and risk factors of cholesterol gallstones, a highly prevalent Western disease. The etiology of cholesterol cholelithiasis is considered to be multifactorial, with interaction of genetic and environmental factors. Mechanisms of cholesterol lithogenesis include biliary cholesterol hypersecretion, supersaturation and crystallization, stone formation and growth, and bile stasis within the gallbladder. Each of these various steps could be under genetic control and/or be influenced through intermediate pathogenic steps linked to a variety of environmental factors.
- ItemVariation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans(ELSEVIER SCIENCE BV, 2008) Kovacs, Peter; Kress, Rahel; Rocha, Jacqueline; Kurtz, Ulrike; Miquel, Juan Francisco; Nervi, Flavio; Mendez Sanchez, Nahum; Uribe, Misael; Bock, Hans H.; Schirin Sokhan, Ramin; Stumvoll, Michael; Moessner, Joachim; Lammert, Frank; Wittenburg, HenningBackground/Aims: From quantitative trait locus mapping in inbred mice, we identified the Nr1h4 gene encoding the nuclear bile salt receptor FXR as a candidate gene for the cholesterol gallstone susceptibility locus Lith7. Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans.