DSpace Angular :: Browsing by Author "Navarrete, Carlos"

Browsing by Author "Navarrete, Carlos"

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Adiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children
(ELSEVIER IRELAND LTD, 2010) Arnaiz, Pilar; Acevedo, Monica; Barja, Salesa; Aglony, Marlene; Guzman, Beatriz; Cassis, Berta; Carvajal, Jacqueline; Moreno, Manuel; Navarrete, Carlos; Berrios, Ximena
Background: Low levels of adiponectin have been associated with metabolic risk factors (RF) and cardiac disease. Minimal data is available about the relationship between adiponectin and subclinical atherosclerosis. Objectives: To determine the relationship of adiponectin to cardiometabolic RF, C-reactive protein (CRP), anthropometric parameters of obesity, and subclinical atherosclerosis in children.
Biochemical predictors of cardiac rhythm at 1 year follow-up in patients with non-valvular atrial fibrillation
(2012) Acevedo, Monica; Corbalan, Ramon; Braun, Sandra; Pereira, Jaime; Gonzalez, Ilse; Navarrete, Carlos
C-reactive protein (CRP) is increased in patients with atrial fibrillation (AF) and it might predict the lack of sinus rhythm maintenance in the long term follow-up. Scarce data have been reported relating endothelial dysfunction and/or haemostatic or platelet markers to sinus rhythm maintenance in AF patients. We aimed to determine whether some biochemical markers including soluble thrombomodulin (sTM), soluble P-selectin, thrombin-antithrombin (TAT) complex and CRP levels could predict sinus rhythm maintenance at 1 year follow-up in non-valvular AF patients. 130 patients (70 males, mean age 67 +/- A 13 years) with newly diagnosed AF na < ve of antithrombotic or antiplatelet therapy were studied. Baseline CRP, P-selectin, sTM and TAT levels were compared to those of 20 matched-healthy subjects in sinus rhythm. AF patients had significantly higher plasma CRP (10.5 +/- A 2.2 vs 3.25 +/- A 0.3 mg/l, p = 0.001), P-selectin (219 +/- A 141 vs 126 ng/ml, p = 0.01), and TAT (54 +/- A 237 vs 2.7 +/- A 3.3 ng/l, p = 0.001) levels compared with controls. Soluble TM levels, although higher than controls, did not reach statistical significance. Multivariate regression analyses showed that elevated CRP (OR = 4.8, p = 0.02) and sTM (OR = 1.05, p = 0.04) were the only two predictors of lack of sinus rhythm at 1 year follow-up. An altered inflammatory, haemostatic, endothelial and platelet environment exists in newly diagnosed AF patients. CRP and sTM levels might be used as biochemical markers to predict the status of cardiac rhythm at 1 year follow-up in some AF patients.
Body fat and its relationship with clustering of cardiovascular risk factors
(2015) Valentino Peirano, Giovanna Francesca; Bustamante, María José; Orellana, Lorena; Krämer Karmy, Verónica; Durán Agüero, Samuel; Adasme, Marcela; Salazar, Alejandra; Ibarra, Camila; Fernández, Marcelo; Navarrete, Carlos; Acevedo B., Mónica
Cardiorespiratory fitness improves prediction of mortality of standard cardiovascular risk scores in a Latino population
(2020) Acevedo, Monica; Valentino, Giovanna; Jose Bustamante, Maria; Orellana, Lorena; Adasme, Marcela; Baraona, Fernando; Corbalan, Ramon; Navarrete, Carlos
Background Cardiorespiratory fitness (CRF) is a powerful predictor of mortality. This study evaluated the predictive value of CRF for mortality in Chilean subjects without atherosclerotic disease compared with the Framingham, European Systematic Coronary Risk Evaluation (SCORE), and 2013 ACC/AHA risk scores and determined the incremental predictive value of CRF when added to these scores. Hypothesis CRF improves prediction of all-cause and cardiovascular disease (CVD)-related mortality of the standard international risk scores. Methods Cross-sectional study, which evaluated 4064 subjects between 2002 and 2016. Cardiovascular (CV) risk factors, anthropometric and biochemical parameters, and blood pressure were measured. CRF was determined by metabolic equivalents during maximum stress test. The Framingham, SCORE, and ACC/AHA risk scores were calculated for all subjects. After a median follow-up of 9 years, all-cause and CVD-related mortality were assessed. Receiver operating curves were built to determine mortality prediction for CRF, the risk scores, and CRF added to the scores. Results As of August 2016, 99 deaths were reported, 33 of which were CVD-related. All risk scores and CRF predicted CVD-related mortality, with CRF identified as the best predictor: CRF: C = 0.88 (95% CI: 0.82-0.93) vs Framingham: C = 0.68 (95% CI: 0.60-0.76), SCORE: C = 0.76 (95% CI: 0.70-0.83), and ACC/AHA: C = 0.79 (95% CI: 0.73-0.85). Predictive power of the three scores improved when CRF was added to the model, but this was only significant for the Framingham score. Conclusions CRF is a good predictor of both, all-cause and CV mortality and a better predictor of CVD-related deaths than standard risk scores in this population.
Cardiovascular risk factors among young subjects with high carotid intima media thickness
(SOC MEDICA SANTIAGO, 2011) Acevedo, Monica; Kraemer, Veronica; Tagle, Rodrigo; Arnaiz, Pilar; Corbalan, Ramon; Berrios, Ximena; Navarrete, Carlos
Background: Cardiovascular risk factor (RF) assessment is essential to prevent and predict cardiovascular disease. The presence of RF at early ages, are determinant for the presence of atherosclerosis later in life. Aim: To determine the RF profile of young subjects with high carotid intima media thickness (CIMT). Material and Methods: We studied 689 subjects (50% women, mean age 36 6 years) from Santiago, Chile. We determined body mass index (BMI), waist circumference, blood pressure, fasting serum lipids, blood glucose and C-reactive protein. CIMT was assessed by ultrasound using an automatic border recognition software. Results: Body mass index, waist circumference, blood pressure and serum lipids were significantly higher among subjects located in the higher CIMT quartile. Also, subjects in the higher quartile of CIMT had a higher prevalence of three or more RF compared with the lower quartile (p = 0.01). Finally, individuals with three or more RF showed three times more risk of being in the higher CIMT quartile, than subjects with no RF (odds ratio = 3.1, p < 0.01). Conclusions: There is a negative influence of cardiovascular RF on CIMT among young subjects. (Rev Med Chile 2011; 139: 1322-1329).
Cardiovascular risk factors in a group of health care workers
(SOC MEDICA SANTIAGO, 2012) Kramer, Veronica; Adasme, Marcela; Jose Bustamante, M.; Jalil, Jorge; Navarrete, Carlos; Acevedo, Monica
Background: Health promotion can be carried out at work places. Aim: To assess cardiovascular risk factors among workers of a University hospital. Material and Methods: Cross sectional study of 888 participants (aged 41 +/- 11 years, 76% women), who answered a survey about cardiovascular risk factors. Body mass index, waist, blood pressure and total cholesterol (TC) by capillary method were determined. Results: Self reported prevalence of risk factors were as follows: 19% of participants had high blood pressure, 30% hypercholesterolemia, 6% diabetes, 41% smoked, 88% were sedentary and 26% had a family history of cardiovascular diseases. Five percent of participants did not have any risk factor, 20% had one risk factor, 32% had two and 43% had three or more. The highest frequency of lack of awareness was about blood glucose values. A high blood cholesterol level was found in 27% of those reporting normal cholesterol levels. Likewise, a high body mass index was found in 18% of those reporting a normal weight. Conclusions: The prevalence of cardiovascular risk factors in this group of participants is similar to that found in the last national health survey in Chile. Noteworthy is the lack of awareness about these risk factors. (Rev Med Chile 2012; 140: 602-608).
Cholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction
(2013) Martínez, Gonzalo; Rigotti Rivera, Attilio; Acevedo B., Mónica; Navarrete, Carlos; Rosales Núñez, Juan Elizabeth; Giugliano, Robert P, Corbalán Herreros, Ramón
Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor
(HINDAWI LTD, 2015) Acevedo, Monica; Varleta, Paola; Kramer, Veronica; Valentino, Giovanna; Quiroga, Teresa; Prieto, Carolina; Parada, Jacqueline; Adasme, Marcela; Briones, Luisa; Navarrete, Carlos
High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoproteinassociated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS. Results. Mean age was 46 +/- 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 +/- 48 nmol/mL/min, and mean hsCRP was 2.1 +/- 2.2mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P = 0.03) and hsCRP (P < 0.0001) than those without MS. ROC curves showed that both markers predictedMS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects withMS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.
High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern
(LIPPINCOTT WILLIAMS & WILKINS, 2007) Gonzalez, Gilberto; Alvarado, Jose N.; Rojas, Auristela; Navarrete, Carlos; Velasquez, Carmen G.; Arteaga, Eugenio
Objective: To assess the prevalence of vitamin D deficiency in healthy postmenopausal women with normal sun exposure but without vitamin D fortification in their diets.
Hipertensión arterial: el factor de riesgo más importante para grosor íntima-media carotídeo elevado y placa carotídea en adultos de Santiago
(SOC MEDICA SANTIAGO, 2011) Acevedo, Monica; Tagle, Rodrigo; Kramer, Veronica; Arnaiz, Pilar; Marin, Arnaldo; Pino, Felipe; Godoy, Ivan; Berrios, Ximena; Navarrete, Carlos
Background: Carotid Ultima media thickness (CIMT) is a marker of cardiovascular damage that can be modified by traditional risk factors. Aim: To determine attributable risk factors for a high CIMT among healthy adults. Material and Methods: A sample of 1270 individuals (636 males and 634 females) aged 44 +/- 11 years, was studied. Blood pressure, weight, height, lipid profile and blood glucose were measured in all. CIMT and the presence of atherosclerotic plaques were determined by carotid ultrasound. Standard criteria were used to define hypertension, dyslipidemia and diabetes. Results: Mean CIMT in the sample studied was 0.62 +/- 0.01 mm and percentile 75 was 0.67. The most important risk factor for a CIMT over percentile 75 and the presence of atherosclerotic plaques was hypertension with attributable risks of 54 and 57%, respectively. Conclusions: In this sample, the main risk factor for a high CIMT was hypertension. (Rev Med Chile 2011; 139: 290-297).
Impaired Fasting Glucose in Nondiabetic Range : Is It a Marker of Cardiovascular Risk Factor Clustering?
(2015) Valentino Peirano, Giovanna Francesca; Kramer, Verónica; Orellana, Lorena; Bustamante, María José; Casasbellas, Cinthia; Adasme, Marcela; Salazar, Alejandra; Navarrete, Carlos; Acevedo B., Mónica
Low Cardiovascular Disease Awareness in Chilean Women: Insights from the ESCI Project
(2020) Varleta, Paola; Acevedo, Monica; Casas-Cordero, Carolina; Berrios, Amalia; Navarrete, Carlos
Background: Although cardiovascular disease (CVD) is the leading cause of mortality in Latin American women, limited data exist on CVD perceptions in this population. This study aimed to assess CVD awareness and knowledge of women from Santiago, Chile.
Mobile-phone text messaging to promote ideal cardiovascular health in women
(2023) Acevedo, Monica; Varleta, Paola; Casas-Cordero, Carolina; Berrios, Amalia; Navarrete, Carlos; Valentino, Giovanna; Lopez, Rosario; Smith, Sidney C.
ObjectiveIdeal cardiovascular health (CVH) was developed to promote CVH as a key component of primordial prevention. Mobile short message service (SMS) is useful for improving health behaviours. We aim to test the effectiveness of SMS intervention in women to improve CVH.MethodsIn a single-blinded, randomised, controlled study, 620 women, aged 35-70 years, without cardiovascular disease, were enrolled in SMS intervention versus no SMS. CVH metrics by self-report, and biochemical laboratory, anthropometric and blood pressure measurements were collected during home visits at baseline and 9 months. Women were categorised as having poor (0-2), intermediate (3-4) or ideal (5-7) CVH according to the number of ideal CVH metrics. Participants were randomised 1:1 to SMS intervention versus control. SMS was sent every 5-6 days for 9 months. The primary outcome was the difference in the proportion of women with ideal CVH between SMS and control groups at 9 months. Rates of intermediate CVH, poor CVH and each of the seven ideal CV health metrics at 9 months were key secondary endpoints.ResultsAt 9 months, there was no significant difference between groups for the primary outcome (16.3% at baseline and 13.3% at 9 months, and 10.1% and 11.1%, in SMS and control groups, respectively, adjusted RR 1.0; 95% CI 0.6 to 1.6). Similarly, there were no significant differences between groups for the key secondary endpoints. SMS had an acceptance rate of 94.9%.ConclusionsBehavioural SMS intervention did not improve rates of ideal CVH in women, despite being feasible and well received.
Patient Adherence to a Cardiovascular Rehabilitation Program : What Factors Are Involved?
(2015) Bustamante, María José; Valentino Peirano, Giovanna Francesca; Kramer, Verónica; Adasme, Marcela; Guidi Guillón, Dominique Annette; Ibara, Camila; Casasbellas, Cinthia; Orellana, Lorena; Fernández, Marcelo; Navarrete, Carlos; Mónica Acevedo
Prevalence and determinants of ideal cardiovascular health in a latin women cohort: a cross-sectional study
(2021) Acevedo, Monica; Varleta, Paola; Casas-Cordero, Carolina; Berrios, Amalia; Navarrete, Carlos; Lopez, Rosario
Background: Ideal cardiovascular health (CVH) sought to reduce cardiovascular (CV) morbidity and mortality. In Chile, CV mortality in women is high. The study's main aim was to determine the prevalence of ideal CVH, and the factors and behaviors associated with ideal CVH in women from Santiago de Chile.
¿Sirven los marcadores de riesgo no tradicionales en la diferenciación del riesgo cardiovascular en adultos jóvenes con exceso de peso?
(2013) Krämer Karmy, Verónica; Corbalán Herreros, Ramón; Berríos Carrasola, Ximena; Navarrete, Carlos; Tagle, Rodrigo; Acevedo B., Mónica
Some issues in nonparametric Bayesian modelling using species sampling models
(SAGE PUBLICATIONS LTD, 2008) Navarrete, Carlos; Quintana, Fernando A.; Mueller, Peter
We review some aspects of nonparametric Bayesian data analysis with discrete random probability measures. We focus on the class of species sampling models (SSMs). We critically investigate the common use of the Dirichlet process (DP) prior as a default SSM choice. We discuss alternative prior specifications from a theoretical, computational and data analysis perspective. We conclude with a recommendation to consider SSM priors beyond the special case of the DP prior, and make specific recommendations on how different choices can be used to reflect prior information and how they impact the desired inference. We show the required changes in the posterior simulation schemes, and argue that the additional generality can be achieved without additional computational effort.
Total/HDL cholesterol ratio and non HDL cholesterol as predictors for increased intima media thickness
(SOC MEDICA SANTIAGO, 2012) Acevedo, Monica; Kraemer, Veronica; Tagle, Rodrigo; Corbalan, Ramon; Arnaiz, Pilar; Berrios, Ximena; Navarrete, Carlos
Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and Methods: Lipid profile, height, weight, blood pressure and bilateral IMT measured by ultrasound with automatic border recognition software, were assessed in 770 men and 854 women aged 45 +/- 11 years, in Santiago de Chile. Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. Mean IMT was 0.62 mm. All lipid markers were significantly correlated with IMT This correlation was higher for non-HDL cholesterol (r = 0.24, p < 0.0001) and total/HDL cholesterol ratio(r = 0.23, p < 0.0001). In both men and women, total/HDL cholesterol ratio was the best predictor of having an IMT over the 75th percentile (odds ratio 1.21, 95% confidence intervals 1.09-1.35, p < 0.01). Conclusions: Total/HDL cholesterol ratio was the best determinant of subclinical atherosclerosis. (Rev Med Chile 2012; 140: 969-976).

Browsing by Author "Navarrete, Carlos"

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