Browsing by Author "Munoz G."

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    Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk populationEvaluación de Trefoil factor 3 como un biomarcador no invasivo para la detección de metaplasia intestinal y cáncer gástrico en una población de alto riesgo
    (2022) Latorre G.; Pizarro M.; Vargas J.I.; Espino A.; Aguero C.; Gonzalez R.; Riquelme A.; Gandara V.; Munoz G.; Ford J.S.; Araya J.C.; Bellolio E.; Villaseca M.; Fuentes-Lopez E.; Cortes P.; Rollan A.; Bufadel M.E.; Araya R.; Sharp A.; Donoso A.; Bresky G.; Pedrero P.; Rueda C.; Calvo A.; Parra-Blanco A.; Odagaki T.; Moriyama T.; Ishida T.; Camargo M.C.; Corvalan A.H.
    © 2022 Elsevier España, S.L.U.Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia. Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Methods: Single-center, cross-sectional study of 274 patients who consecutively underwent upper gastrointestinal endoscopy with gastric biopsies (updated Sydney system). TFF3 levels were measured in serum by a commercial ELISA kit. Patients with normal histology or chronic atrophic gastritis without intestinal metaplasia comprised the control group. In addition, 14 patients with invasive gastric cancer were included as a reference group. The association between TFF3 levels and intestinal metaplasia was assessed by logistic regression. Results: Patients with intestinal metaplasia (n = 110) had a higher median TFF3 level as compared to controls (n = 164), 13.1 vs. 11.9 ng/mL, respectively (p = 0.024). Multivariable logistic regression showed a no significant association between TFF3 levels and intestinal metaplasia (OR = 1.20; 95%CI: 0.87–1.65; p-trend = 0.273). The gastric cancer group had a median TFF3 level of 20.5 ng/mL, and a significant association was found (OR = 3.26; 95%CI: 1.29–8.27; p-trend = 0.013). Conclusion: Serum levels of TFF3 do not discriminate intestinal metaplasia in this high-risk Latin American population. Nevertheless, we confirmed an association between TFF3 levels and invasive gastric cancer.
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    Principals' leadership practices and learning results. Toward concepts capable of guiding empirical investigationPRÁCTICAS DE LIDERAZGO DIRECTIVO Y RESULTADOS DE APRENDIZAJE. HACIA CONCEPTOS CAPACES DE GUIAR LA INVESTIGACIÓN EMPÍRICA
    (2009) Weinstein J.; Munoz G.; Garay S.; Horn A.; Marfan J.; Uribe M.; Concha C.; Volante P.; Anderson S.
    © 2022 Centro de Estudios de Promoción de la Lectura y Literatura Infantil, Universidad de Castilla-La Manc. All rights reserved.This article explores reading mediators’ literary mediation in adverse contexts and unconventional spaces (such as camps, hospitals, community centres, and others) in Mexico and Chile. Through a deductive thematic analysis of 20 interviews, a relationship is established between literary mediation and Joan Tronto’s (1993) four categories of the ethics of care (caring about, caring for, caregiving, and care receiving). It is concluded that literary mediation in these contexts takes the form of an accompaniment that is organized through an emerging methodology with communities. This methodology focuses on listening and is intuitively oriented and situated, which supports both recreational and diversion practices, as well as processes of self-knowledge and emotional containment. The discussion centres on how this mediation practice engages with both a humanitarian logic of care and with practices that decentralize the book’s authority and stature to pursue other relationalities.