Browsing by Author "Munoz, Hernan R."
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- ItemDexamethasone for postoperative nausea and vomiting prophylaxis: effect on glycaemia in obese patients with impaired glucose tolerance(LIPPINCOTT WILLIAMS & WILKINS, 2009) Nazar, Claudio E.; Lacassie, Hector J.; Lopez, Rodrigo A.; Munoz, Hernan R.Background and objective Dexamethasone given to prevent postoperative nausea and vomiting may produce significant hyperglycaemia in the perioperative period. effect of dexamethasone on patients with impaired tolerance is unknown.
- ItemObesity Does Not Influence the Onset and Offset of Sevoflurane Effect as Measured by the Hysteresis Between Sevoflurane Concentration and Bispectral Index(LIPPINCOTT WILLIAMS & WILKINS, 2011) Cortinez, Luis I.; Gambus, Pedro; Troconiz, Inaki F.; Echevarria, Ghislaine; Munoz, Hernan R.BACKGROUND: The onset and offset of action of anesthetic gases might be delayed by respiratory changes and gas exchange alterations present in obese patients. In this study, we assessed the influence of obesity on the hysteresis between sevoflurane and its effect as measured by the bispectral index (BIS). Because the use of positive end-expiratory pressure (PEEP) in obese patients has improved gas exchange, we also assessed the influence of PEEP on hysteresis.
- ItemPerformance of the cerebral state index during increasing levels of propofol anesthesia: A comparison with the bispectral index(LIPPINCOTT WILLIAMS & WILKINS, 2007) Cortinez, Luis I.; Delfino, Alejandro E.; Fuentes, Ricardo; Munoz, Hernan R.BACKGROUND: The cerebral state monitor is a new device to measure depth of anesthesia. In this study we compared the cerebral state monitor with the bispectral index (BIS) monitor during propofol anesthesia.
- ItemPharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years(LIPPINCOTT WILLIAMS & WILKINS, 2008) Cortinez, Luis I.; Fuentes, Ricardo; Solari, Sandra; Ostermann, Paola; Vega, Miguel; Munoz, Hernan R.BACKGROUND: Caudal administration of levobupivacaine (2.5 mg/kg) in children is used frequently in some hospitals. However, no reports of levobupivacaine concentrations have been published with this dosing scheme. We report the results of a study on the pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 yr.
- ItemThe Effective Effect-Site Propofol Concentration for Induction and Intubation with Two Pharmacokinetic Models in Morbidly Obese Patients Using Total Body Weight(LIPPINCOTT WILLIAMS & WILKINS, 2012) Echevarria, Ghislaine C.; Elgueta, Maria F.; Donoso, Maria T.; Bugedo, Diego A.; Cortinez, Luis I.; Munoz, Hernan R.BACKGROUND: Most pharmacokinetic (PK) models used for propofol administration are based on studies in normal-weight patients. Extrapolation of these models for morbidly obese patients is controversial. Using 2 PK models and a target-controlled infusion system, we determined the predicted propofol effect-site concentration (Ce) needed for induction of anesthesia in morbidly obese subjects using total body weight.
- ItemThe Influence of Age on the Dynamic Relationship Between End-Tidal Sevoflurane Concentrations and Bispectral Index(LIPPINCOTT WILLIAMS & WILKINS, 2008) Cortinez, Luis I.; Troconiz, Inaki F.; Fuentes, Ricardo; Gambus, Pedro; Hsu, Yung Wei; Altermatt Couratier, Fernando René; Munoz, Hernan R.BACKGROUND: Age is an important determinant of the pharmacokinetic profile of inhaled anesthetics. The influence of age on the dynamic profile of sevoflurane's effect has not been well described. We performed this study to characterize the influence of age and other covariates on the dynamic relationship between sevoflurane end-tidal concentration (C-ET) and its effect measured by bispectral index (BIS).