Browsing by Author "Muccioli, Giulio G."
Now showing 1 - 5 of 5
Results Per Page
Sort Options
- ItemANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES(2016) Andrea Ibacache, Juana; Valderrama, Jaime A.; Arancibia, Veronica; Theoduloz, Cristina; Muccioli, Giulio G.; Benites, JulioA variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 mu M. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line.
- ItemANTIPROLIFERATIVE. ACTIVITY. OF. NEW. 6-BROMINE. DERIVATIVES. OF. 7-ANILINO-1-ARYLISOQUINOLINEQUINONES(2016) Ibacache, Juana Andrea; Valderrama Guerrero, Jaime Adolfo; Arancibia Moya, Verónica; Theoduloz, Cristina; Muccioli, Giulio G.
- ItemEco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones(2013) Arenas, Paola; Peña, Andrés; Ríos, David; Benites, Julio; Muccioli, Giulio G.; Calderón, Pedro Buc; Valderrama Guerrero, Jaime Adolfo
- ItemSynthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives(2016) Valderrama Guerrero, Jaime Adolfo; Delgado Chang, Virginia; Sepúlveda, Sandra; Benites, Julio; Theoduloz, Cristina; Buc Calderón, Pedro; Muccioli, Giulio G.
- ItemSynthesis, half-wave potentials and antiproliferative activity of 1-Aryl-substituted aminoisoquinolinequinones(2014) Ibacache, Juana Andrea; Delgado Chang, Virginia; Benites, Julio; Theoduloz, Cristina; Arancibia Moya, Verónica; Muccioli, Giulio G.; Valderrama Guerrero, Jaime Adolfo