Browsing by Author "Muñoz, R."
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- ItemBaseline glycated hemoglobin levels are associated with duodenal-jejunal bypass liner-induced weight loss in obese patients(2014) Muñoz, R.; Domínguez de Landa, María Angélica; Muñoz, F.; Muñoz, C.; Slako, M.; Turiel, D.; Pimentel Muller, Fernando; Sharp Pittet, Allan Carlos; Escalona, Alex
- ItemBile acids synthesis decreases after laparoscopic sleeve gastrectomy(2016) Escalona, Alex; Muñoz, R.; Irribarra Pastenes, Verónica; Solari Gajardo, Sandra; Allende, Fidel; Miquel P., Juan Francisco
- ItemConvalescent plasma in COVID-19. Mortality-safety first results of the prospective multicenter FALP 001-2020 trial(2020) Gazitúa, R.; Briones, J. L.; Selman, C.; Villarroel Espíndola, F.; Aguirre, A.; González Steigmaier, R.; Cereceda, K.; Mahave, M.; Rubio, B.; Ferrer Rosende, P.; Sapunar, J.; Marsiglia, H.; Morales, R.; Yarad, F.; Balcells Marty, María Elvira; Rojas, Luis; Nervi Nattero, Bruno; Nien, J. K.; Garate, J.; Prieto, C.; Palma, S.; Escobar, C.; Bascuñan, J.; Muñoz, R.; Pinto, M.; Cardemil, D.; Navarrete, M.; Reyes, S.; Espinosa, V.; Yáñez, N.; Caglevic, C.
- ItemDuodenal-jejunal bypass liner to treat type 2 diabetes mellitus in morbidly obese patients(2014) Muñoz, R.; Escalona, Alex
- ItemGenome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages(2014) Lee Liu, D.; Moreno, M.; Almonacid, L. I.; Tapia, V. S.; Muñoz, R.; von Marées, J.; Gaete Carrasco, Marcia; Melo Ledermann, Francisco Javier; Larraín Correa, Juan AgustínBackground Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during metamorphosis. We envision that comparative studies between regenerative and non-regenerative stages in Xenopus could aid in understanding why spinal cord regeneration fails in human beings. Results To identify the mechanisms that allow the tadpole to regenerate and inhibit regeneration in the froglet, we obtained a transcriptome-wide profile of the response to spinal cord injury in Xenopus regenerative and non-regenerative stages. We found extensive transcriptome changes in regenerative tadpoles at 1 day after injury, while this was only observed by 6 days after injury in non-regenerative froglets. In addition, when comparing both stages, we found that they deployed a very different repertoire of transcripts, with more than 80% of them regulated in only one stage, including previously unannotated transcripts. This was supported by gene ontology enrichment analysis and validated by RT-qPCR, which showed that transcripts involved in metabolism, response to stress, cell cycle, development, immune response and inflammation, neurogenesis, and axonal regeneration were regulated differentially between regenerative and non-regenerative stages. Conclusions We identified differences in the timing of the transcriptional response and in the inventory of regulated transcripts and biological processes activated in response to spinal cord injury when comparing regenerative and non-regenerative stages. These genes and biological processes provide an entry point to understand why regeneration fails in mammals. Furthermore, our results introduce Xenopus laevis as a genetic model organism to study spinal cord regeneration.
- ItemInfluencia del nivel de carga y microclima sobre la composición y calidad de bayas, mosto y vino de Cabernet-sauvignon.(2002) Muñoz, R.; Pérez, J.; Pszczolkowski Tomaszewski, Philippo; Bordeu Schwarze, Edmundo; Bordeu Schwarze, Edmundo
- ItemLarger sizes of massive quiescent early-type galaxies in clusters than in the field at 0.8 < z < 1.5(2014) Delaye, L.; Huertas-Company, M.; Mei, S.; Lidman, C.; Licitra, R.; Newman, A.; Raichoor, A.; Shankar, F.; Barrientos, Luis Felipe; Bernardi, M.; Cerulo, P.; Couch, W.; Demarco, R.; Muñoz, R.; Sánchez-Janssen, R.; Tanaka, M.
- ItemPeripheral, but not central, GLP-1 receptor signaling is required for improvement in glucose tolerance after Roux-en-Y gastric bypass in mice.(2016) Carmody, Jill S.; Muñoz, R.; Yin, Huali; Kaplan, Lee M.
- ItemSimultaneous TAPP inguinal repair and laparoscopic cholecystectomy: results of a case series(2019) Quezada Sanhueza, Nicolás; Maturana, G.; Pimentel, E.; Crovari Eulufi, Fernando; Muñoz, R.; Jarufe Cassis, Nicolás; Pimentel Muller, Fernando
- ItemSyndecan-4 Regulates Non-Canonical Wnt Signalling and Is Essential for Convergent and Extension Movements in Xenopus Embryos(2006) Muñoz, R.; Larraín Correa, Juan Agustín
- ItemThe morphological transformation of red sequence galaxies in clusters since z ~ 1(2017) Cerulo, P.; Couch, W. J.; Lidman, C.; Demarco, R.; Huertas Company, M.; Mei, S.; Sánchez Janssen, R.; Barrientos, Luis Felipe; Muñoz, R.
- ItemxSyndecan-4 Regulates Gastrulation and Neural Tube Closure in Xenopus Embryos(2006) Muñoz, R.; Larraín Correa, Juan Agustín