Browsing by Author "Muñoz, Juan P."

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    Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives
    (MDPI, 2022) Osorio, Julio C.; Blanco, Rancés; Corvalan, Alejandro H.; Muñoz, Juan P.; Calaf, Gloria M.; Aguayo, Francisco
    © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein– Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.
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    Tobacco smoke activates human papillomavirus 16 p97 promoter and cooperates with High-Risk E6/E7 for oxidative DNA damage in lung cells
    (2015) Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, María L.; Corvalán R., Alejandro; Soto Rifo, Ricardo; Aguayo González, Francisco
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    Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells
    (2017) Carrillo, Diego; Muñoz, Juan P.; Huerta, Hernán; Leal, Gabriel; Corvalán R., Alejandro; León, Oscar; Calaf, Gloria M.; Urzúa, Ulises; Boccardo, Enrique; Aguayo González, Francisco