Browsing by Author "Moya, Esteban A."

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    Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
    (2015) Krause Leyton, Bernardo; Del Rio, Rodrigo; Moya, Esteban A.; Marquez Gutiérrez, Mónica; Casanello Toledo, Paola Cecilia; Iturriaga Agüera, Rodrigo
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    Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia
    (2012) Del Rio, Rodrigo; Moya, Esteban A.; Parga, Maria J.; Madrid, Carlos; Iturriaga, Rodrigo
    Chronic intermittent hypoxia (CIH), a main feature of obstructive sleep apnoea (OSA), increases hypoxic ventilatory responses and elicits hypertension, partially attributed to an enhance carotid body (CB) responsiveness to hypoxia. As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA.
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    Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment
    (2011) Del Rio, Rodrigo; Munoz, Cristian; Arias, Paulina; Court, Felipe A.; Moya, Esteban A.; Iturriaga, Rodrigo
    Del Rio R, Munoz C, Arias P, Court FA, Moya EA, Iturriaga R. Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment. Am J Physiol Lung Cell Mol Physiol 301: L702-L711, 2011. First published August 5, 2011; doi:10.1152/ajplung.00128.2011.-Chronic intermittent hypoxia (CIH), a characteristic of sleep obstructive apnea, enhances carotid body (CB) chemosensory responses to hypoxia, but its consequences on CB vascular area and VEGF expression are unknown. Accordingly, we studied the effect of CIH on CB volume, glomus cell numbers, blood vessel diameter and number, and VEGF immunoreactivity (VEGF-ir) in male Sprague-Dawley rats exposed to 5% O-2, 12 times/h for 8 h or sham condition for 21 days. We found that CIH did not modify the CB volume or the number of glomus cells but increased VEGF-ir and enlarged the vascular area by increasing the size of the blood vessels, whereas the number of the vessels was unchanged. Because oxidative stress plays an essential role in the CIH-induced carotid chemosensory potentiation, we tested whether antioxidant treatment with ascorbic acid may impede the vascular enlargement and the VEGF upregulation. Ascorbic acid, which prevents the CB chemosensory potentiation, failed to impede the vascular enlargement and the increased VEGF-ir. Thus present results suggest that the CB vascular enlargement induced by CIH is a direct effect of intermittent hypoxia and not secondary to the oxidative stress. Accordingly, the subsequent capillary changes may be secondary to the mechanisms involved in the neural chemosensory plasticity induced by intermittent hypoxia.
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    Effect of insular cortex inactivation on autonomic and behavioral responses to acute hypoxia in conscious rats
    (2013) Casanova, José Patricio; Contreras Abarca, Marco; Moya, Esteban A.; Torrealba, Fernando; Iturriaga Agüera, Rodrigo
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    Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia
    (2018) Moya, Esteban A.; Arias, Paulina; Iturriaga Agüera, Rodrigo