Browsing by Author "Mora, Sergio"

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    Association of N-cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons
    (2015) Castañeda, Patricia; Muñoz, Mauricio; García Rojo, Gonzalo; Ulloa, José L.; Bravo, Javier A.; Márquez, Ruth; García Pérez, María Alexandra; Arancibia, Damaris; Araneda, Karina; Rojas, Paulina S.; Mondaca Ruff, David; Díaz Véliz, Gabriela; Mora, Sergio; Aliaga, Esteban; Fiedler Temer, Jenny
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    Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) rnRNA and integrin alpha 5 expression in the rat pineal gland
    (ELSEVIER SCIENCE BV, 2006) Dagnino Subiabre, Alexies; Zepeda Carreno, Rodrigo; Diaz Veliz, Gabriela; Mora, Sergio; Aboitiz, Francisco
    Chronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. Moreover, stress induces deleterious actions on the epithalamic pineal organ, a gland involved in a wide range of physiological functions. The aim of this study was to investigate whether the stress effects on the pineal gland are related with changes in the expression of neurotrophic factors and cell adhesion molecules. Using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, we analyzed the effect of chronic immobilization stress on the BDNF mRNA and integrin alpha 5 expression in the rat pineal gland. We found that BDNF is produced in situ in the pineal gland. Chronic immobilization stress induced upregulation of BDNF mRNA and integrin alpha 5 expression in the rat pineal gland but did not produce changes in beta-actin mRNA or in GAPDH expression. Stressed animals also evidenced an increase in anxiety-like behavior and acute gastric lesions. These results suggest that BDNF and integrin a5 may have a counteracting effect to the deleterious actions of immobilization stress on functionally stimulated pinealocytes. Furthermore, this study proposes that the pineal gland may be a target of glucocorticoid damage during stress. (c) 2006 Elsevier B.V. All rights reserved.
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    The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
    (2017) García Rojo, Gonzalo; Fresno, Cristóbal; Vilches, Natalia; Díaz Véliz, Gabriela; Mora, Sergio; Aguayo, Felipe; Pacheco, Aníbal; Parra Fiedler, Nicolás; Parra, Claudio S.; Fiedler Temer, Jenny; Rojas, Paulina S.; Tejos, Macarena; Aliaga, Esteban