Browsing by Author "Montiel, J"

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    Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu
    (2005) Inestrosa, NC; Reyes, AE; Chacón, MA; Cerpa, W; Villalón, A; Montiel, J; Merabachvili, G; Aldunate, R; Bozinovic, F; Aboitiz, F
    It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (A beta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguA beta and humanA beta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged 0. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD. (c) 2004 Elsevier Inc. All rights reserved.
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    Long distance communication in the human brain: timing constraints for inter-hemispheric synchrony and the origin of brain lateralization
    (SOCIEDAD BIOLGIA CHILE, 2003) Aboitiz, F; Lopez, J; Montiel, J
    Analysis of corpus callosum fiber composition reveals that inter-hemispheric transmission time may put constraints on the development of inter-hemispheric synchronic ensembles, especially in species with large brains like humans. In order to overcome this limitation, a subset of large-diameter callosal fibers are specialized for fast interhemispheric transmission, particularly in large-brained species. Nevertheless, the constraints on fast interhemispheric communication in large-brained species can somehow contribute to the development of ipsilateral, intrahemispheric networks, which might promote the development of brain lateralization.