Browsing by Author "Miranda, José Patricio"

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    Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children
    (2024) Bravo, Carolina; Mericq, Verónica; Pereira, Ana; Corvalán, Camila; Tobar, Hugo E.; Miranda, José Patricio; Santos, José Luis
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    Correction to: Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys (Human Genetics, (2021), 10.1007/s00439-021-02290-3)
    (Springer Science and Business Media Deutschland GmbH, 2021) Vicuña, Lucas; Norambuena, Tomás; Miranda, José Patricio; Eyheramendy, Susana; Pereira, Ana; Mericq, Verónica; Ongaro, Linda; Montinaro, Francesco; Lorenzoni Santos, José Guillermo
    © 2021, Springer-Verlag GmbH Germany, part of Springer Nature.Several typos were introduced in the original article and they have been corrected. The original article has been revised.
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    Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys
    (2021) Miranda, José Patricio
    Puberty is a complex developmental process that varies considerably among individuals and populations. Genetic factors explain a large proportion of the variability of several pubertal traits. Recent genome-wide association studies (GWAS) have identified hundreds of variants involved in traits that result from body growth, like adult height. However, they do not capture many genetic loci involved in growth changes over distinct growth phases. Further, such GWAS have been mostly performed in Europeans, but we do not know how these findings relate to other continental populations. In this study, we analyzed the genetic basis of three pubertal traits; namely, peak height velocity (PV), age at PV (APV) and height at APV (HAPV). We analyzed a cohort of 904 admixed Chilean children and adolescents with European and Mapuche Native American ancestries. Height was measured on roughly a 6-month basis from childhood to adolescence between 2006 and 2019. We predict that the difference in HAPV between an European and a Mapuche adolescent is 4.3 cm higher in the European (P = 0.042) and APV is 0.73 years later for the European compared with the Mapuche adolescent on average (P = 0.023). Further, by performing a GWAS on 774, 433 single-nucleotide polymorphisms, we identified a genetic signal harboring 3 linked variants significantly associated with PV in boys (P < 5 x 10(-8)). This signal has never been associated with growth-related traits.