Browsing by Author "Meza Viteri Victor Manuel"

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    Adición de melatonina a terapia con hipotermia para encefalopatía hipóxico-isquémica neonatal
    (Medwave Estudios Ltda, 2022) Meza Viteri Victor Manuel; Toso Milos Paulina Alejandra
    Introduction: Neonatal hypoxic-ischemic encephalopathy is caused by perinatal asphyxia, resulting in an acute neurological dysfunction of variable severity. It occurs in one to six of every 1000 full-term newborns and is associated with high neonatal morbimortality and adverse neurological outcomes. The use of hypothermia is considered the standard therapy for this condition. How-ever, different adjuvant therapeutic options have been proposed due to lim-ited clinical efficacy, including drugs like melatonin. There is controversy about whether combined therapy with melatonin is superior to monother-apy with hypothermia. Methods We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, and Cochrane, among others. We ex-tracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of the findings table using the GRADE approach. Results We identified two systematic reviews that included two primary studies, both randomized trials. The two randomized trials were included in the analysis of the present work.