Browsing by Author "Mesa, Tomas"

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    Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Adults with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations
    (2024) Mitchell, James W.; Sossi, Frieda; Miller, Isabel; Jaber, Paula Blancarte; Das-Gupta, Zofia; Fialho, Luz Sousa; Amos, Action; Austin, Joan K.; Badzik, Scott; Baker, Gus; Ben Zeev, Bruria; Bolton, Jeffrey; Chaplin, John E.; Cross, J. Helen; Chan, Derrick; Gericke, Christian A.; Husain, Aatif M.; Lally, Lorraine; Mbugua, Sharon; Megan, Cassidy; Mesa, Tomas; Nunez, Lilia; von Oertzen, Tim J.; Perucca, Emilio; Pullen, Angie; Ronen, Gabriel M.; Sajatovic, Martha; Singh, Mamta B.; Wilmshurst, Jo M.; Wollscheid, Leonie; Berg, Anne T.
    At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. Therefore, the International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts in epilepsy, people with epilepsy and their representatives to develop minimum sets of standardized outcomes and outcomes measurement methods for clinical practice that support patient-clinician decision-making and quality improvement. Consensus methods identified 20 core outcomes. Measurement tools were recommended based on their evidence of strong clinical measurement properties, feasibility, and cross-cultural applicability. The essential outcomes included many non-seizure outcomes: anxiety, depression, suicidality, memory and attention, sleep quality, functional status, and the social impact of epilepsy. The proposed set will facilitate the implementation of the use of patient-centered outcomes in daily practice, ensuring holistic care. They also encourage harmonization of outcome measurement, and if widely implemented should reduce the heterogeneity of outcome measurement, accelerate comparative research, and facilitate quality improvement efforts.
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    Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Infants, Children, and Adolescents with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations
    (2024) Mitchell, James W.; Sossi, Frieda; Miller, Isabel; Jaber, Paula Blancarte; Das-Gupta, Zofia; Fialho, Luz Sousa; Amos, Action; Austin, Joan K.; Badzik, Scott; Baker, Gus; Ben Zeev, Bruria; Bolton, Jeffrey; Chaplin, John E.; Cross, J. Helen; Chan, Derrick; Gericke, Christian A.; Husain, Aatif M.; Lally, Lorraine; Mbugua, Sharon; Megan, Cassidy; Mesa, Tomas; Nunez, Lilia; von Oertzen, Tim J.; Perucca, Emilio; Pullen, Angie; Ronen, Gabriel M.; Sajatovic, Martha; Singh, Mamta B.; Wilmshurst, Jo M.; Wollscheid, Leonie; Berg, Anne T.
    At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. The International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts in epilepsy, people with epilepsy, and their representatives to develop minimum sets of standardized outcomes and outcome measurement methods for clinical practice. Using modified Delphi consensus methods with consecutive rounds of online voting over 12 months, a core set of outcomes and corresponding measurement tool packages to capture the outcomes were identified for infants, children, and adolescents with epilepsy. Consensus methods identified 20 core outcomes. In addition to the outcomes identified for the ICHOM Epilepsy adult standard set, behavioral, motor, and cognitive/language development outcomes were voted as essential for all infants and children with epilepsy. The proposed set of outcomes and measurement methods will facilitate the implementation of the use of patient-centered outcomes in daily practice.
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    Stroke Patterns in Neonatal Group B Streptococcal Meningitis
    (ELSEVIER SCIENCE INC, 2011) Hernandez, Marta I.; Sandoval, Carmen C.; Tapia, Jose L.; Mesa, Tomas; Escobar, Raul; Huete, Isidro; Wei, Xing Chang; Kirton, Adam
    Neonatal group B streptococcus meningitis causes neurologic morbidity and mortality. Cerebrovascular involvement is a common, poorly studied, and potentially modifiable pathologic process. We hypothesized that imaging patterns of focal brain infarction are recognizable in neonatal group B streptococcal meningitis. A consecutive case series included term neonates with the following: (1) bacterial meningitis, (2) acute group B streptococcal infection (positive cerebrospinal fluid/blood culture), (3) brain magnetic resonance imaging within 14 days, and (4) acute intraparenchymal focal infarctions (restricted diffusion). Lesions within known arterial territories were classified as arterial ischemic stroke. Clinical presentations, investigations, and neurologic outcomes were recorded. Eight newborns (50% female) with focal infarction were identified. Five presented early (<1 week), and all manifested clinical shock and elevated acute-phase reactants. Less than 50% had prenatal group B streptococcal screening, while 2 of 3 screened were negative. Two distinct patterns of focal infarction were identified: (1) deep perforator arterial stroke to basal ganglia, thalamus, and peri ventricular white matter (7/8, 88%), and (2) superficial injury with patchy, focal infarctions of the cortical surface (6/8, 75%). Outcomes (mean 23.8 months) were poor, with severe disability or death in 6/8 (75%). Recognizable stroke patterns contribute to severe neurologic outcomes and represent a potentially modifiable pathophysiologic process in neonatal group B streptococcal meningitis. (C) 2011 Elsevier Inc. All rights reserved.