Browsing by Author "Melo, Ricardo"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    CHARACTERIZATION OF PHENOLIC ACIDS PROFILE FROM CHILEAN RED WINES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
    (2011) Mendoza, Leonora; Matsuhiro, Betty; Aguirre Brockway, Mariana Javiera; Isaacs Casanova, Mauricio; Sotes, Gaston; Cotoras Tadic, Milena; Melo, Ricardo
  • No Thumbnail Available
    Item
    Characterization of the Fungitoxic Activity on Botrytis cinerea of N-phenyl-driman-9-carboxamides
    (2021) Melo, Ricardo; Armstrong, Veronica; Navarro, Freddy; Castro, Paulo; Mendoza, Leonora; Cotoras, Milena
    A total of 12 compounds were synthesized from the natural sesquiterpene (-) drimenol (compounds 4 to 15). The synthesized compounds corresponded to N-phenyl-driman-9-carboxamide derivatives, similar to some fungicides that inhibit the electron-transport chain. Their structures were characterized and confirmed by H-1 NMR, C-13 NMR spectroscopy, and mass spectrometry. Compounds 5 to 15 corresponded to novel compounds. The effect of the compounds on the mycelial growth of Botrytis cinerea was evaluated. Methoxylated and chlorinated compounds in the aromatic ring (compounds 6, 7, 12, and 13) exhibited the highest antifungal activity with IC50 values between 0.20 and 0.26 mM. On the other hand, the effect on conidial germination of B. cinerea of one methoxylated compound (6) and one chlorinated compound (7) was analyzed, and no inhibition was observed. Additionally, compound 7 decreased 36% the rate of oxygen consumption by germinating conidia.