Browsing by Author "Massardo, Loreto"

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    A Consensus Position Paper From REAL-PANLAR Group About the Methodological Approach for the Accreditation Process of Centers of Excellence in Rheumatoid Arthritis in Latin America
    (2019) Santos-Moreno, Pedro; Caballero-Uribe, Carlo V.; Cardiel, Mario H.; Galarza-Maldonado, Claudio; Massardo, Loreto; Pineda, Carlos; Soriano, Enrique; Alberto Castro, Carlos; Villarreal, Laura; Buitrago, Diana
    Background By 2015, the World Health Organization reported that 1% of the world population suffered from rheumatoid arthritis (RA) and in Latin America (LA) between 0.5% and 1%. Previously, in May 2014, a consensus meeting was held in Barranquilla, Colombia, where the Project for Implementation and Accreditation of Centers of Excellence (CoE) in RA in LA was established, which then became an official special group of the Pan American League of Associations for Rheumatology (PANLAR). Objective The aim of this study was to define the methodological approach for the accreditation process of CoE in RA in LA. Methods A meeting was held in April 2015 with participation of the members of the REAL-PANLAR Steering Committee, and representatives of several LA countries, with the support of 2 experts in accreditation processes and models in Colombia. Then, in November 2015 in San Francisco and in November 2016 in Washington, the REAL-PANLAR Steering Committee met to discuss some final aspects of the project. Results The following steps for accreditation were defined: application for accreditation, issuance of the concept of assessment of the entity, accreditation decision, and monitoring accreditation. Conclusions This is the second REAL-PANLAR consensus paper with the purpose to define the parameters for the accreditation process for future CoE in RA in LA.
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    An update on neuropsychiatric lupus with emphasis in cognitive dysfunction
    (SOC MEDICA SANTIAGO, 2012) Leon, Tomas; Henriquez, Carla; Calderon, Jorge; Massardo, Loreto
    Patients with systemic lupus erythematosus (SLE) suffer from a number of neuropsychiatric (NP) symptoms throughout their disease affecting them both physically and psychologically We review herein the nomenclature and case definitions for neuropsychiatric lupus syndromes proposed by the American College of Rheumatology in 1999. We emphasize cognitive dysfunction and discuss etiological hypotheses, especially those related to the presence of antineuronal autoantibodies. (Rev Med Chile 2012; 140; 1333-1341).
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    Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation
    (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009) Norambuena, Andres; Metz, Claudia; Vicuna, Lucas; Silva, Antonia; Pardo, Evelyn; Oyanadel, Claudia; Massardo, Loreto; Gonzalez, Alfonso; Soza, Andrea
    Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent pro-apoptotic agent in Jurkat T cells inducing a complex phospholipase D/phosphatidic acid signaling pathway that has not been reported for any galectin before. Gal-8 increases phosphatidic signaling, which enhances the activity of both ERK1/2 and type 4 phosphodiesterases (PDE4), with a subsequent decrease in basal protein kinase A activity. Strikingly, rolipram inhibition of PDE4 decreases ERK1/2 activity. Thus Gal-8-induced PDE4 activation releases a negative influence of cAMP/protein kinase A on ERK1/2. The resulting strong ERK1/2 activation leads to expression of the death factor Fas ligand and caspase-mediated apoptosis. Several conditions that decrease ERK1/2 activity also decrease apoptosis, such as anti-Fas ligand blocking antibodies. In addition, experiments with freshly isolated human peripheral blood mononuclear cells, previously stimulated with anti-CD3 and anti-CD28, show that Gal-8 is pro-apoptotic on activated T cells, most likely on a subpopulation of them. Anti-Gal-8 autoantibodies from patients with systemic lupus erythematosus block the apoptotic effect of Gal-8. These results implicate Gal-8 as a novel T cell suppressive factor, which can be counterbalanced by function-blocking autoantibodies in autoimmunity.
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    Management of Patients With Rheumatoid Arthritis in Latin America A Consensus Position Paper From Pan-American League of Associations of Rheumatology and Grupo Latino Americano De Estudio de Artritis Reumatoide
    (LIPPINCOTT WILLIAMS & WILKINS, 2009) Massardo, Loreto; Suarez Almazor, Maria E.; Cardiel, Mario H.; Nava, Arnulfo; Levy, Roger A.; Laurindo, Ieda; Soriano, Enrique R.; Acevedo Vazquez, Eduardo; Millan, Alberto; Pineda Villasenor, Carlos; Galarza Maldonado, Claudio; Caballero Uribe, Carlo V.; Espinosa Morales, Rolando; Pons Estel, Bernardo A.
    Objective: A consensus meeting of representatives of 18 Latin-American and Caribbean countries gathered in Renaca, Chile, for 2 days to identify problems and provide recommendations for the care of patients with rheumatoid arthritis (RA) in Latin America, a region where poverty and other health priorities make the efforts to provide effective and high quality care difficult. This report includes recommendations for health professionals, patients, and health authorities in Latin America, with an emphasis oil education and therapeutic issues.
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    Treatment of Early Rheumatoid Arthritis in a Multinational Inception Cohort of Latin American Patients The GLADAR Experience
    (LIPPINCOTT WILLIAMS & WILKINS, 2012) Cardiel, Mario H.; Pons Estel, Bernardo A.; Sacnun, Monica P.; Wojdyla, Daniel; Saurit, Veronica; Carlos Marcos, Juan; Pinto, Maria Raquel C.; Cordeiro de Azevedo, Ana Beatriz; da Silveira, Ines Guimaraes; Radominski, Sebastiao C.; Ximenes, Antonio C.; Massardo, Loreto; Ballesteros, Francisco; Rojas Villarraga, Adriana; Valle Onate, Rafael; Portela Hernandez, Margarita; Esquivel Valerio, Jorge A.; Garcia De la Torre, Ignacio; Khoury, Vianna J.; Millan, Alberto; Roberto Soriano, Enrique; GLADAR
    Background: Treatment of rheumatoid arthritis (RA) has evolved dramatically in the last decade. However, little is known about the way rheumatologists in Latin America treat their patients in clinical practice, outside the scope of clinical trials.