Browsing by Author "Martinez-Molina, Maria Paz"

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    Oscillatory activity underlying cognitive performance in children and adolescents with autism: a systematic review
    (2024) Soto-Icaza, Patricia; Soto-Fernandez, Patricio; Kausel, Leonie; Marquez-Rodriguez, Victor; Carvajal-Paredes, Patricio; Martinez-Molina, Maria Paz; Figueroa-Vargas, Alejandra; Billeke, Pablo
    Autism spectrum disorder (ASD) is a neurodevelopmental condition that exhibits a widely heterogeneous range of social and cognitive symptoms. This feature has challenged a broad comprehension of this neurodevelopmental disorder and therapeutic efforts to address its difficulties. Current therapeutic strategies have focused primarily on treating behavioral symptoms rather than on brain psychophysiology. During the past years, the emergence of non-invasive brain stimulation techniques (NIBS) has opened alternatives to the design of potential combined treatments focused on the neurophysiopathology of neuropsychiatric disorders like ASD. Such interventions require identifying the key brain mechanisms underlying the symptomatology and cognitive features. Evidence has shown alterations in oscillatory features of the neural ensembles associated with cognitive functions in ASD. In this line, we elaborated a systematic revision of the evidence of alterations in brain oscillations that underlie key cognitive processes that have been shown to be affected in ASD during childhood and adolescence, namely, social cognition, attention, working memory, inhibitory control, and cognitive flexibility. This knowledge could contribute to developing therapies based on NIBS to improve these processes in populations with ASD.
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    Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
    (2024) Kausel, Leonie; Figueroa-Vargas, Alejandra; Zamorano, Francisco; Stecher, Ximena; Aspe-Sanchez, Mauricio; Carvajal-Paredes, Patricio; Marquez-Rodriguez, Victor; Martinez-Molina, Maria Paz; Roman, Claudio; Soto-Fernandez, Patricio; Valdebenito-Oyarzo, Gabriela; Manterola, Carla; Uribe-San-Martin, Reinaldo; Silva, Claudio; Henriquez-Ch, Rodrigo; Aboitiz, Francisco; Polania, Rafael; Guevara, Pamela; Munoz-Venturelli, Paula; Soto-Icaza, Patricia; Billeke, Pablo
    Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID-19, identifying factors that can distinguish individuals at risk of developing brain alterations is crucial for prioritizing follow-up care. Here, we report findings from a sample of patients consisting of 73 adults with a mild to moderate SARS-CoV-2 infection without signs of respiratory failure and 27 with infections attributed to other agents and no history of COVID-19. The participants underwent cognitive screening, a decision-making task, and MRI evaluations. We assessed for the presence of anosmia and the requirement for hospitalization. Groups did not differ in age or cognitive performance. Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r = - 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. Hence, anosmia could be a factor to be considered when identifying at-risk populations for follow-up.