Browsing by Author "Martinez, Servet"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Genome-wide identification of new Wnt/β-catenin target genes in the human genome using CART method
    (2010) Hodar, Christian; Assar, Rodrigo; Colombres, Marcela; Aravena, Andres; Pavez, Leonardo; Gonzalez, Mauricio; Martinez, Servet; Inestrosa, Nibaldo C.; Maass, Alejandro
    Background: The importance of in silico predictions for understanding cellular processes is now widely accepted, and a variety of algorithms useful for studying different biological features have been designed. In particular, the prediction of cis regulatory modules in non-coding human genome regions represents a major challenge for understanding gene regulation in several diseases. Recently, studies of the Wnt signaling pathway revealed a connection with neurodegenerative diseases such as Alzheimer's. In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/beta-catenin pathway target genes potentially involved in brain diseases.