Browsing by Author "Martinez, Alejandro"

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    A wireless pressure sensor for monitoring pulmonary artery pressure in advanced heart failure: Initial experience
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo F.; Concepcion, Roberto; Bourge, Robert C.; Martinez, Alejandro; Alcaino, Milton; Deck, Carlos; Ferrada, Marcela; Alfaro, Mario; Perrone, Sergio
    Hemodynamic goals have been used in the past to guide therapy in patients with heart failure (HF). For HF patients whose signs and symptoms of congestion do not resolve with initial therapy it appears reasonable to consider hemodynamic monitoring at experienced sites. It has been suggested that implantable hemodynamic sensors may enable frequent monitoring of hemodynamic changes in HF patients and be used in tailoring vasodilator. We present the first human case of radio-frequency based, wireless pressure sensor for the monitoring of pulmonary artery pressure in patients with advanced HF. This sensor is delivered into the pulmonary artery via percutaneous venous access.
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    Association of Remote Hypertension in Pregnancy With Coronary Artery Disease A Case-Control Study
    (LIPPINCOTT WILLIAMS & WILKINS, 2009) Valdes, Gloria; Quezada, Felipe; Marchant, Eugenio; von Schultzendorff, Astrid; Moran, Sergio; Padilla, Oslando; Martinez, Alejandro
    Because hypertensive pregnancies have been associated with increased cardiovascular disease, we aimed to identify whether angiographically characterized coronary artery disease differed in women with previous normotensive pregnancies or hypertensive pregnancies (HPs). The study group included 217 parous women, aged 60.9 +/- 9.2 (SD) years, who required coronary angiography between January 2006 and December 2007, 36.8 +/- 9.9 and 28.8 +/- 10.5 years after their first and last pregnancy, respectively; 146 had normotensive pregnancies and 71 had >= 1 HP, according to a questionnaire including reproductive history and cardiovascular risks. Body mass index, smoking, and frequency of diabetes were similar in both groups. Chronic hypertension (93% versus 78%; P=0.007), hyperlipidemia (82% versus 69%; P=0.049), and premature familial cardiovascular disease (42% versus 20%; P=0.001) prevailed in HPs. Participants with HPs were younger (58.9 +/- 8.3 versus 61.9 +/- 9.6 years; P=0.025) than participants with normotensive pregnancies. Although 49% of all participants had hemodynamically significant coronary artery disease (>= 70% stenosis), no differences were observed between groups in the number of stenotic arteries; however, their number increased by 28% and 22% over a 10-year period in HPs and normotensive pregnancies, respectively (P=0.034). Multivariate analysis showed that HPs had a nonsignificant risk of having coronary artery disease (odds ratio: 1.21; 95% CI: 0.64 to 2.28), and being a current smoker (odds ratio: 4.13; 95% CI: 1.85 to 9.25), a diabetic (odds ratio: 2.29; 95% CI: 1.85 to 9.25), or having a family history of premature cardiovascular disease (odds ratio: 2.34; 95% CI: 1.17 to 2.39) significantly increased the risk of coronary artery disease. This study demonstrates that women with HPs have earlier coronary disease, probably related to intermediate cardiovascular risks that have a gestational expression. (Hypertension. 2009; 53: 733-738.)
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    Caracterización clínica de pacientes chilenos con displasia fibrosa/síndrome de McCune-Albright
    (2022) Jimenez Sandoval, Catalina de Los Ángeles; Schneider, Paulina; Baudrand Biggs, René Felipe; García, Hernán; Martinez, Alejandro; Mendoza, Carolina; Grob Lunecke, Francisca Andrea; Seiltgens Sorrel, Cristián; Florenzano Valdés, Pablo Felipe
    Background: Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS) is characterized by a spectrum of manifestations that may include fibrous dysplasia of bone and multiple endocrinopathies. Aim: To describe the clinical spectrum, the study and follow-up of patients with FD/MAS cared at our institution. Material and Methods: Review of medical records of 12 pediatric and adult patients (11 women) who met the clinical and genetic diagnostic criteria for FD/ MAS. Results: The patients’ mean age at diagnosis was 4.9 ± 5.5 years. The most common initial clinical manifestation was peripheral precocious puberty (PPP) in 67% of patients and 75% had café-au-lait spots. Fibrous dysplasia was present in 75% of patients and the mean age at diagnosis was 7.9 ± 4.7 years. Ten patients had a bone scintigraphy, with an age at the first examination that varied between 2 and 38 years of age. The most frequent location of dysplasia was craniofacial and appendicular. No patient had a recorded history of cholestasis, hepatitis, or pancreatitis. In four patients, a genetic study was performed that was positive for the pathogenic variant of guanine nucleotide binding protein, alpha stimulating (GNAS). Conclusions: These patients demonstrate the variable nature of the clinical presentation and study of FD/MAS. It is essential to increase the index of diagnostic suspicion and adherence to international recommendations.
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    Radiofrequency based wireless pressure sensor is a reliable method for hemodynamic assessment in ambulatory chronic heart failure patients: Comparison to swan-ganz catheter and echocardiography.
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo; Verdejo, Hugo; Bourge, Robert; Concepcion, Roberto; Ferrada, Marcela; Martinez, Alejandro; Alcaino, Milton; Alfaro, Mario; Godoy, Ivan; Perrone, Sergio